CAS: 51076-46-1; 2-(Pyridin-4-yl)Malonaldehyde

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696-30-0 6304-16-1 28356-58-3

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picoline Vilsmeier reagent N,N-dimethyl-formamide pyridine-4-acetic acid 4-(1H-pyrazole-4-yl)pyridine 1,2-dihydro-2-oxo-5-(4-pyridinyl)nicotinic acid (S)-N-((3-(3-fluoro-4-(4-(pyridin-4-yl)-1H-pyrazol-1-yl)-phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide N-Acetylamrinone

吡啶-4-乙酸置于sodium Hydroxide,三氯氧磷体系中,用 水 作为反应溶剂,化学反应 5.25H,反应生成 2-(4-吡啶)丙二醛
参考文献:Design,Synthesis,And Biologic Evaluation Of Some Novel N-Arylpyrazole Derivatives As Cytotoxic Agents
标题:Design,Synthesis,And Biologic Evaluation Of Some Novel N-Arylpyrazole Derivatives As Cytotoxic Agents
摘要:A Novel Series Of N-Arylpyrazole Derivatives (5A-5D,7A-7C) Has Been Designed And Synthesized Via Aromatic Substitution Reaction Of N-Nonsubstituted Pyrazoles With 4-Fluoronitrobenzene In The Presence Of Base. The Structures Of These Compounds Were Established On The Basis Of Elemental (C,H,And N) And Spectral Analysis (H-1 NMR,C-13 NMR,Hrms,And Ft-Ir). All The Compounds Were Tested For Their Cytotoxic Activity In Vitro Against Four Human Tumor Cell Lines: Carcinoma (Bel-7402),Nasopharyngeal Carcinoma (Kb),Immature Granulocyte Leukemia (Hl-60),And Gastrocarcinoma (Bgc-823) By The 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide Assay. The Results Showed That Most Of The Obtained Compounds Exhibited Promising Cytotoxicity Against Tested Carcinoma Cell Lines With Low Ic50 Values. The Bis-Pyrazole Derivative 7C,Bearing Alkoxy Group On The 5-Position Of Phenyl Ring,Was The Most Effective One. It Is Inhibition Of Cell Growth Of Bel-7402 Cells Was 1.5-Fold Higher Than That Found For Cisplatin. And,Also Mono-Pyrazole Derivatives 5A And 5B,Decorated With Trifluoromethyl Group On The Phenyl Ring,Displayed Better Cytotoxicity Than That Of Cisplatin Against Bel-7402 Cell Line.
DOI:10.1007/s00044-013-0552-1

专利信息

专利号:US-6891069-B1
优先权日:2004-01-30
标 题:Synthesis of 4-substituted phthalaldehyde
发明人：ZHU PETER C; WANG DER-HAW
权利人:ETHICON INC
摘要:Disclosed herein are methods of synthesizing a 4-substituted-benzene-1,2-carbaldehyde. In one aspect, a method may include reacting a 4-substituted-1,2-bis(dibromomethyl) benzene with sulfuric acid to form a reaction product, introducing a solid sodium bicarbonate into the reaction product, and hydrolyzing the reaction product to form a 4-substituted-benzene-1,2-carbaldehyde, after introducing the bicarbonate.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-7476767-B2
优先权日:2004-01-30
标题:Alpha-hydroxy sulfonate aldehydes, germicidal compositions containing the alpha-hydroxy sulfonate aldehydes, or mixtures of alpha-hydroxy sulfonate aldehydes and phthalaldehydes, and methods of using the compounds or compositions for disinfection or sterilization
发明人：ZHU PETER C; ROBERTS CHARLES G; TRAN YVONNE
权利人:ETHICON INC
摘要:Disclosed herein are α-Hydroxy sulfonate aldehydes and synthesis methods therefor. Germicidal compositions including the α-hydroxy sulfonate aldehydes, are also disclosed. In one aspect, a germicidal composition may include a diluent, and a germicidally effective amount of a water-soluble germicidal compound including an aldehyde group and an α-hydroxy sulfonate group. The water-soluble compound may have a solubility of at least 5 (w/v) % in water. In a further aspect, the compound may include 1-hydroxy-3-oxo-2-phenyl-propane-1-sulfonic acid salt, (2-formyl-phenyl)-hydroxy-methane sulfonic acid salt, 1-hydroxy-2-(4-methanesulfonyl-2-nitro-phenyl)-3-oxo-propane-1-sulfonic acid salt, 2-bromo-1-hydroxy-3-oxo-propane-1-sulfonic acid salt, 2-chloro-1-hydroxy-3-oxo-propane-1-sulfonic acid salt, 2-(1-formyl-2-hydroxy-2-sulfo-ethyl)-isonicotinic acid salt, 2-benzooxazol-2-yl-1-hydroxy-3-oxo-propane-1-sulfonic acid salt, or 1-hydroxy-2-(4-methoxy-phenyl)-3-oxo-propane-1-sulfonic acid salt. Germicidal compositions including a mixture of an α-hydroxy sulfonate aldehyde and one or more phthalaldehydes, such as phthalaldehyde, isophthalaldehyde, terephthalaldehyde, or a combination thereof, are also disclosed. Methods of using the compounds or compositions for killing bacteria, disinfection, or sterilization, are also disclosed.

专利号:EP-1559704-A1
优先权日:2004-01-30
标 题 :Synthesis of 4-substituted phthalaldehyde