CAS: 383-70-0; (2,2,2-Trifluoroacetyl)Glycine

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聚甘氨酸 以 四氢呋喃,氯仿,Petroleum Ether 作为反应溶剂,化学反应生成 L-三氟乙酰甘氨酸
参考文献:Structural Mimetics Of Proline-Rich Peptides And Their Use
标题:Structural Mimetics Of Proline-Rich Peptides And Their Use
摘要:本发明提供了一个包含一般式1的化合物: 在一般式1中,X至少是o和s中的一个.a是一个环桥.y1至少是h,烷基,氟烷基,芳基和杂环芳基中的一个.z1,Z2,Z3分别或交替地至少是h,羰基,Oh,O-烷基,O-酰基,N-r1R2(其中r1或r2分别或交替地至少是h,烷基,酰基和磺酰基中的一个),烷基,酰基,氟烷基,芳基和杂环芳基中的一个.r1至少是烷基,酰基,烷氧羰基,芳氧羰基和氨基羰基中的一个.r2至少是h,烷基,芳基,烷基羰基,芳基羰基,烷氧羰基,氨基羰基,芳氧羰基,烷基磺酰基,芳基磺酰基,氨基酰基和肽基中的一个.本发明还涉及将该化合物用作药物活性化合物的用途,以及将药物活性化合物用于治疗细菌性疾病,神经退行性疾病和肿瘤的用途.

专利信息

专利号:US-2022298204-A1
优先权日:2019-07-05
标题 :Synthesis of a-amanitin and its derivatives
发明人：SIEGERT MARY-ANN; KNITTEL CAROLINE HERTA; SÃœSSMUTH RODERICH
权利人:PURE BIOORGANICS SIA
摘要:The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.

专利号:EP-3792250-A1
优先权日:2019-09-13
标题:Synthesis of alpha-amanitin and its derivatives
发明人：SIEGERT MARY-ANN; KNITTEL CAROLINE HERTA; SÃœSSMUTH RODERICH
权利人:PURE BIOORGANICS SIA
摘要:The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.

专利号:US-11584708-B2
优先权日:2018-03-29
标题 :Synthesis of (2S,3R,4R)-4,5-dihydroxyisoleucine and derivatives
发明人：KNITTEL CAROLINE; SIEGERT MARY-ANN; SÃœSSMUTH RODERICH; WINK CHRISTOPH; JAS GERHARD
权利人:HEIDELBERG PHARMA RES GMBH
摘要:The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diastereomer mix by acylase, and subsequent Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoic acid derivative.

专利号:US-2021009507-A1
优先权日:2018-03-29
标题:Synthesis of (2S,3R,4R)-4,5-Dihydroxyisoleucine and Derivatives

专利号:WO-2019185877-A1
优先权日:2018-03-29
标 题:Synthesis of (2s,3r,4r)-4,5-dihydroxyisoleucine and derivatives

专利号:EP-3908587-B1
优先权日:2019-01-09
标题 :Method for synthesis of diazabicyclo[6.2.0]decane related compounds