CAS: 3382-18-1; 6,7-Dimethoxy-3,4-Dihydroisoquinoline

上下游产品

N-[2-(3,4-dimethoxyphenyl)ethyl]formamide 1,2,3,4-tetrahydro-6,7-dimethoxy-2-(3,4-dimethoxybenzyl)isoquinoline H-pyrido[2,1-a]isoquinoline-3-carboxylic acid ethyl ester1-ethyl-9,10-dimethoxy-2-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-3-carboxylic acid ethyl ester H-pyrido[2,1-a]isoquinoline-3-carboxylic acid ethyl ester1-isobutyl-9,10-dimethoxy-2-oxo-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-3-carboxylic acid ethyl ester -6,7-dimethoxy-3,4-dihydro-is°Chinoliniumbromid2-β-(3,4-Dimethoxy-phenyl)-ethyl-6,7-dimethoxy-3,4-dihydro-is°Chinoliniumbromid 6,7-dimethoxy-2-methyl-3,4-dihydro-isoquinolinium; chloride 2-benzoyl-6,7-dimethoxy-3,4-dihydro-isoquinolinium; compound with 6,7-dimethoxy-3,4-dihydro-isoquinoline 6,7-dimethoxy-2-(4-nitro-benzoyl)-3,4-dihydro-isoquinolinium; compound with 6,7-dimethoxy-3,4-dihydro-isoquinoline

📜6,7-Dimethoxy-3,4-Dihydroisoquinoline Perchlorate置于sodium Hydroxide体系中,用 水 作为反应溶剂,以92%的收率获得产物6,7-二甲氧基-3,4-二氢异喹啉
参考文献:通过castagnoli-Cushman协议,一步一步路线到三环稠合的1,2,3,4-四氢异喹啉系统.
标题:通过castagnoli-Cushman协议,一步一步路线到三环稠合的1,2,3,4-四氢异喹啉系统.
摘要:3,4-二氢异喹啉与戊二酸酐,其氧和硫类似物的castagnoli-Cushman反应作为一步法研究了苯并[A]喹喔啉系统及其杂环类似物.延伸到吡咯并[2,1-A使用琥珀酸酐可实现]异喹啉体系.结果证明了一种未探索的方法,用于引入包含桥头氮原子的上述三环退火系统.通过1D和2D NMR技术确定了新化合物的结构和相对构型.1-甲基二氢异喹啉与戊二酸,二乙醇酸和琥珀酸酐之间的反应产生出乎意料的含有环外双键的异喹啉衍生物.制备的化合物具有成为未来合成生物活性分子的基础.
DOI:10.3762/bjoc.16.121

专利信息

专利号:US-2006287529-A1
优先权日:2003-02-20
标 题:Solid phase synthesis of antitumoral compounds
发明人：ALVAREZ MERCEDES; ALBERICIO FERNANDO; CIRONI PABLO; CUE VAS CARMEN; FRANCESCH ANDREAS; MARFIL MARTA
权利人:ALVAREZ MERCEDES; ALBERICIO FERNANDO; CIRONI PABLO; CUE VAS CARMEN; FRANCESCH ANDREAS; MARFIL MARTA
摘要:Lamellarins are prepared using a solid phase synthesis. In a first aspect, the process includes a step as follows: Formula (I) where R 1 to R 15 are as defined, and X is halogen, provided that one of R 2 , R 3 or R 4 is immobilised to a resin. In a second aspect, the process includes a step as follows: Formula (II) where R 1 ′ to R 5 ′, R 11 ′ and R 13 ′ are as defined, X 1 and X 2 are halogen, M is a metal function and PG is an amino protecting group, provided that one of that R 2 ′, R 3 ′ or R 4 ′ is immobilised to a resin.

专利号:US-2024239791-A1
优先权日:2021-04-26
标题 :Processes for the synthesis of valbenazine
发明人：TUCKER JOHN LLOYD
权利人:NEUROCRINE BIOSCIENCES INC
摘要:The present application relates to processes for preparing (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).

专利号:US-2022363680-A1
优先权日:2019-09-13
标题 :Processes for the synthesis of valbenazine
发明人：TUCKER JOHN; KUCERA DAVID; HETTINGER DONALD; COCHRAN BRIAN M; BRANUM SHAWN; LE JACKIE; MCGEE KEVIN
权利人:NEUROCRINE BIOSCIENCES INC
摘要:The present application relates to processes for making (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b -hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl (S)-2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).

专利号:WO-2022232060-A1
优先权日:2021-04-26
标 题:Processes for the synthesis of valbenazine

专利号:EP-1613635-A2
优先权日:2003-02-20
标题 :Solid phase synthesis of antitumoral compounds

专利号:WO-2021050977-A1
优先权日:2019-09-13
标 题 :Processes for the synthesis of valbenazine