CAS: 2739-97-1; 2-Pyridylacetonitrile

相似化合物

16179-97-8 13115-43-0 14993-80-7

上下游产品

CAS号372-48-5 2-氟吡啶 | CAS号75-05-8 乙腈 | CAS号109-04-6 2-溴吡啶 | CAS号928664-98-6 4-异恶唑硼酸频哪醇酯 | CAS号109-09-1 2-氯吡啶 | CAS号5451-39-8 吡啶-2-乙酰胺 | CAS号55401-97-3 2-溴甲基吡啶 | CAS号54765-14-9 2-乙醛基吡啶 | CAS号151-50-8 氰化钾 | CAS号493038-87-2 4-(2-吡啶基)-5-氨基吡唑 | CAS号35853-55-5 双[2,8-二(三氟甲基)喹啉... | CAS号59576-30-6 异丙基-2-吡啶酮 | CAS号22346-07-2 alpha-(2-methyl... | CAS号98-98-6 2-吡啶甲酸 | CAS号23580-81-6 2-Propanone,1,3... | CAS号2739-98-2 2-吡啶乙酸乙酯 | CAS号154411-16-2 N-(1-CYANO-4-OX... | CAS号32081-58-6 3-甲基-2-吡啶-2-丁腈 | CAS号3390-73-6 6-nitro-3-pyrid...

吡啶-2-乙酰胺置于甲基二甲氧基硅烷,Copper Diacetate,1,2-双(二环己基磷基)-乙烷体系中,用 四氢呋喃 用作溶剂,化学反应 12.0H,以81%的收率获得2-吡啶乙腈
参考文献:机理洞察有助于发现使用氢硅烷温和高效的铜催化伯酰胺脱水生成腈的方法
标题:机理洞察有助于发现使用氢硅烷温和高效的铜催化伯酰胺脱水生成腈的方法
摘要:金属催化的伯酰胺甲硅烷基化脱水是合成腈的一种经济方法.我们报告了一种氢化铜 (Cuh) 催化过程,该过程避免了通常具有挑战性的 1,2-硅氧烷消除步骤,从而相对于替代金属催化系统显着提高了整体转化速率.这种新反应在环境温度下进行,可耐受各种金属,酸或碱敏感的官能团,并且可以使用简单的配体,廉价的硅氧烷和低催化剂负载来进行.
Doi:10.1021/jacs.8B00643

专利信息

专利号:US-9920084-B2
优先权日:2011-08-23
标题 :Ionic tags for synthesis of oligoribonucleotides
发明人：DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK-HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER
权利人:DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV; HONG KONG POLYTECHNIC UNIV
摘要:The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

专利号:US-5204456-A
优先权日:1986-04-08
标题:Derivatives of nucleosides and their use for the synthesis of oligonucleotides
发明人：MOLKO DIDIER; SCHULHOF JEAN-CLAUDE; TEOULE ROBERT
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:The invention relates to derivatives of nucleosides and their use for the synthesis of oligonucleotides. These derivatives are in accordance with the formula: (I) in which B represents a radical derived from guanine, cytosine or adenine, whose exocylic NH group is protected by the group with R1 representing a hydrogen atom or a alkyl radical and R2 a hydrogen atom, and alkyl radical, an alkoxy radical and optionally substituted aryloxy radical, R3 represents a hydrogen atom, the dimethoxytrityl radical or the radical R4 represents a hydrogen atom, the radical of formula: or a radical suitable for the synthesis of polynucelotides and R5 represents a hydrogen atom or the protected or unprotected hydroxyl OH radical.

专利号:US-6262251-B1
优先权日:1995-10-19
标题 :Method for solution phase synthesis of oligonucleotides
发明人：PIEKEN WOLFGANG; MCGEE DANNY; SETTLE ALECIA; ZHAI YANSHENG; HUANG JIANPING
权利人:PROLIGO LLC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides. The method lends itself to automation and is ideally suited for large scale manufacture of oligonucleotides with high efficiency.

专利号:US-5874532-A
优先权日:1997-01-08
标 题 :Method for solution phase synthesis of oligonucleotides and peptides
发明人：PIEKEN WOLFGANG; GOLD LARRY
权利人:NEXSTAR PHARMACEUTICALS INC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

专利号:US-6001966-A
优先权日:1995-10-19
标题 :Method for solution phase synthesis of oligonucleotides and peptides
发明人：PIEKEN WOLFGANG; GOLD LARRY
权利人:PROLIGO LLC
摘要:This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

专利号:US-6500955-B1
优先权日:2001-02-02
标 题:One pot synthesis of [2,8-Bis (trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, a mefloquine intermediate
发明人：CHAWLA HARMANDER PAL SINGH; JOHAR PERMINDER SINGH; MITTAL ALKA; MEENA RAM AVTAR; NEGI VILLENDRA SINGH
权利人:NAT INST OF PHARMACEUTICAL EDU
摘要:The present invention provides a simple single step process for the preparation of [2,8-bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, comprising the step of condensing a halo-quinoline with an alpha-picolyl derivatives in the presence of a solvent, a base and a phase transfer catalyst at −10° C. to +90° C.