CAS: 26046-94-6; 5,6-Dihydroxy-2-(4-Hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One

上下游产品

β-D-glucose pentaacetate 4,5,6,7-tetra-O-acetylflavone 7-hydroxy-5,6-diacetoxy-2-(4'-acetoxyphenyl)-4H-1-benzopyran-4-oneD-Glucose scutellarein

📜野黄芩素置于吡啶,喹啉,4-二甲氨基吡啶,Silver(II) Oxide,Palladium 10% On Activated Carbon,氢气,Potassium Carbonate,Copper(II) Sulfate,Potassium Iodide,Sodium Hydroxide体系中,用 乙醇,二氯甲烷,氯仿,丙酮 用作溶剂,25.0 °C,101.33 Kpa 条件下,反应 54.0H,反应生成车前苷
参考文献:Design,Synthesis And Biological Evaluation Of Glucose-Containing Scutellarein Derivatives As Neuroprotective Agents Based On Metabolic Mechanism Of Scutellarin In Vivo
标题:Design,Synthesis And Biological Evaluation Of Glucose-Containing Scutellarein Derivatives As Neuroprotective Agents Based On Metabolic Mechanism Of Scutellarin In Vivo
摘要:Based On Metabolic Mechanism Of Scutellarin In Vivo That Scutellarin Could Be Hydrolyzed Into Scutellarein By Beta-Glucuronide Enzyme,Some Glucose-Containing Scutellarein Derivatives Were Designed And Synthesized Through The Introduction Of Glucose Moiety At C-7 Position Of Scutellarein Via A Glucosidic Bond. Biological Activity Evaluation Showed That These Glucose-Containing Scutellarein Derivatives Exhibited Potent Dpph Radical Scavenging Activities. Furthermore,The Improvement Of Physicochemical Properties Such As Anticoagulant And Neuroprotective Activities Alongside With The Water Solubility Was Achieved By Introducing Glucose. These Findings Suggest That The Introduction Of The Glucose Moiety To Scutellarein Wattants Further Development Of This Kind Of Compounds As Neuroprotective Agents. (C) 2012 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2012.11.002