CAS: 2425-74-3; N-Tert-Butylformamide

该化合物是甲状腺酸的第三级氨化衍生物,其特征是存在与氮原子相连的三丁基乙酸组,该化合物通常用作有机合成的中间体,特别是在制药,农用化学品和特殊化学物的制造过程中. 其严重阻力的丁基亚胺会增强稳定性和影响反应性,使其对选择性转化具有价值. N-tert-Butylformatamide也在某些反应中被用作溶剂或试剂,因为其极性较中且与多种反应条件相容. 化合物的固定结构和一贯纯度使得它成为需要精确氨功能的研究和工业应用的可靠选择.

结构式图片

相似化合物

762-84-5 1118-69-0 1118-12-3

上下游产品

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合成工艺路线路线简述

  • 合成目标产物 N-Tert-Butylformamide 主要起始原料 Carbon Dioxide And Tert-Butylamine
  • (文献来源)合成步骤主要原料 Carbon Dioxide 和 Tert-Butylamine
📜叔丁基亚甲基胺置于sodium Hydroxide,双氧水体系中,用 水 用作溶剂,以89%的收率获得n-叔丁基甲胺
参考文献:Process For Producing N-Monosubstituted Formamides
标题:Process For Producing N-Monosubstituted Formamides
摘要:具有以下公式的n-单取代甲酰胺:##equ1##其中r代表可选择地取代的脂肪族,环脂族或芳香族基团;通过将具有以下公式的甲醛二亚胺:H.Sub.2 C = N--R,其中r如上所定义;或具有以下公式的六氢三唑:##equ2##其中r如上所定义,与过氧化氢反应制备.反应通常在约0oc至约100oc的温度范围内进行.

海关参考信息

专利信息


专利号:US-10364220-B2
优先权日:2012-12-21
标题:Synthesis of succinimides and quaternary ammonium ions for use in making molecular sieves
发明人:SCHMITT KIRK D; ZUSHMA STEPHEN; BURTON ALLEN W
权利人:EXXONMOBIL CHEMICAL PATENTS INC
摘要:The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves.

专利号:US-10253153-B2
优先权日:2015-04-24
标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
发明人:MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
权利人:NITTO DENKO CORP
摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

专利号:US-4879389-A
优先权日:1986-06-25
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人:ACHIWA KAZUO
权利人:ACHIWA KAZUO
摘要:New chiral phosphinopyrrolidine compounds of the general formula: (I) or (I') wherein R1 is a hydrogen atom, -COR, -COOR, -CONHR or -SO2-R where R is an alkyl or aryl group, R2 and R3 each represents independently an aryl group which may have a substituent or substituents, and R4 and R5 each represents independently an aliphatic or cycloaliphatic hydrocarbyl group which may have a substituent or substituents, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:US-8729277-B2
优先权日:2009-04-06
标 题:Processes for the synthesis of gamma nitrocarbonyl and gamma dicarbonyl compounds and their pyrrole derivatives
发明人:YANG HU; BARALT EDUARDO J
权利人:YANG HU; BARALT EDUARDO J; CHEVRON PHILLIPS CHEMICAL CO
摘要:The present invention discloses processes for producing γ-nitrocarbonyl and γ-dicarbonyl compounds, which can be precursors in the synthesis of pyrrole compounds. A process for producing pyrroles such as 2,5-dimethylpyrrole, and structurally similar pyrrole compounds, is also disclosed.

专利号:US-5633373-A
优先权日:1989-07-07
标 题 :Enantioselective synthesis of antifolates
发明人:BARNETT CHARLES J; WILSON THOMAS M
权利人:LILLY CO ELI
摘要:A process and intermediates for the enantioselective synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid are disclosed.

专利号:US-7470792-B2
优先权日:2002-09-13
标题:Process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same
发明人:KOCH GUIDO; LOISELEUR OLIVIER
权利人:NOVARTIS AG
摘要:The present invention provides a synthesis for the preparation of epothilone derivatives of formula 9 n nwherein R1 is methyl, and R2 is an unsubstituted or substituted aryl; an unsubstituted or substituted heteroaryl; or an unsubstituted or substituted heterocyclic radical fused to a benzene nucleus; and salts thereof, and intermediates for the synthesis of a compound of formula 9.

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品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Catalytic Hydrogenation Of Amides To Amines Under Mild Conditions
作者:Mario Stein,Bernhard Breit |发布日期:2013.2.18
摘要:Under (Not So Much) Pressure: A General Method For The Hydrogenation Of Tertiary And Secondary Amides To Amines With Excellent Selectivity Using A Bimetallic Pd-Re Catalyst Has Been Developed. The Reaction Proceeds Under Low Pressure And Comparatively Low Temperature. This Method Provides Organic Chemists With A Simple And Reliable Tool For The Synthesis Of Amines.

合成参考文献


摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#04680
摘要:Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 179
摘要:Bretherick, L. Handbook of Reactive Chemical Hazards. 4th ed. Boston, MA: Butterworth-Heinemann Ltd., 1990, p. 767
摘要:Das, A.; Sarmah, B. K., Science of Synthesis: Knowledge Updates, (2024) 1, 332.
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