📜氯甲酸苄酯置于sodium Carbonate体系中,用 四氢呋喃,水 用作溶剂,化学反应生成5-(苄氧羰基氨基)戊酸 参考文献:Reagents And Methods For Specific Binding Assays 标题:Reagents And Methods For Specific Binding Assays 摘要:本发明涉及双生物素化合物.这些化合物包含两个生物素基团,通过通常至少16个原子长的链连接.双生物素与特定结合对的成员("sbp成员")共轭,其中链不是sbp成员的一部分.还揭示了包括亲和素和上述双生物素复合物的组合物.本发明的化合物和组合物在分析物的分析中发挥作用,其中使用含有亲和素试剂和生物素试剂的试剂体系.本发明的改进包括使用上述的双生物素作为生物素试剂.还揭示了包括本双生物素的试剂盒和制备用于特定结合分析的sbp成员的双生物素化共轭物的方法.
专利号:US-7351852-B2 优先权日:2000-09-05 标题 :T-butoxycarbonylaminoethylamine for the synthesis of PNA monomer units, amino acid derivatives, intermediates therof, and processes for productions of them 发明人:IKEDA HISAFUMI; SAITO ISAO; NAKAMURA YUSHIN 权利人:CREDIA JAPAN CO LTD 摘要:A process for amino acid derivatives shown by the below general formula (I): n n(wherein R 1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II):n n n(wherein R 1 has the same meaning as described above, and R 2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.) as well as amino acid derivatives shown by the general formula (IV):n n n(wherein R 1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms, and n means any one of integers 1-11.), and a process for the amino acid derivative, characterized in that it comprises a reduction step of benzyloxycarbonyl-ω-amino acid derivatives.
专利号:US-7417035-B2 优先权日:1998-11-19 标 题:Phospholipid derivatives of non-steroidal anti-inflammatory drugs 发明人:KOZAK ALEXANDER; SHAPIRO ISRAEL 权利人:DPHARM LTD 摘要:Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the compounds, pharmaceutical compositions comprising the compounds and the use thereof for the treatment of diseases and disorders related to inflammatory conditions.
专利号:US-2004039224-A1 优先权日:2000-09-05 标 题 :T-butoxycarbonylaminoethylamine for the synthesis of pna monomer units, amino acid derivatives, intermediates thereof, and processes for productions of them
专利号:US-2008167491-A1 优先权日:2000-05-09 标题:T-butoxycarbonylaminoethylamine for the Synthesis of PNA Monomer Units, Amino Acid Derivatives, Intermediates Thereof, and Processes for Productions of Them
专利号:US-2005187402-A1 优先权日:2000-09-05 标 题 :T-butoxycarbonylaminoethylamine for the synthesis of PNA monomer units, amino acid derivatives, intermediates thereof, and processes for productions of them
专利号:EP-1318142-A1 优先权日:2000-09-05 标 题:T-butoxycarbonylaminoethylamine for the synthesis of pna monomer units, amino acid derivatives, intermediates thereof, and processes for productions of them
参考文献:10.1186/s41181-025-00420-0 摘要:Obata H, Tsuji AB, Feng Y, Zheng Y, Sugyo A, Sudo H, Kajiwara C, Minegishi K, Zhang MR, Zalutsky MR. 191Pt-labeled trithiol-Hoechst-PSMA: preliminary evaluation of conjugates designed for delivery to genomic DNA of PSMA-positive cancers. EJNMMI Radiopharm Chem. 2026 Jan 09;11(1):10.