CAS: 1840-19-3; 3-(Trifluoromethyl)Phenylisothiocyanate

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CAS号75-15-0 二硫化碳 | CAS号98-16-8 间三氟甲苯胺 | CAS号463-71-8 硫光气 | CAS号594-42-3 全氯甲硫醇 | CAS号96989-50-3 二-2-吡啶基 硫碳酸 | CAS号1736-70-5 3-(三氟甲基)苯(基)硫脲 | CAS号637-19-4 (E)-3-(5-bromot... | CAS号307510-92-5 5-[(4-羧基苯基)亚甲基]... | CAS号20069-30-1 4-[3-(三氟甲基)苯基]-... | CAS号127142-05-6 1-[(E)-1-pyridi... | CAS号315-08-2 2-三氧代-3-(3-三氟亚甲... | CAS号13578-61-5 Thiourea,N-(2-h... | CAS号13578-56-8 N-[3-(trifluoro... | CAS号1736-70-5 3-(三氟甲基)苯(基)硫脲 | CAS号369-90-4 N-(4-Nitropheny... | CAS号871266-82-9 (7-氯噻唑并[5,4-d]嘧...

3-(三氟甲基)苯(基)硫脲 以 氯苯 用作溶剂,化学反应生成阿尔法,阿尔法,阿尔法位-三氟-间-甲苯异硫氰
参考文献:4-取代的1-Ami基硫代氨基脲环化成1,2,4-三唑和1,3,4-噻二唑衍生物
标题:4-取代的1-Ami基硫代氨基脲环化成1,2,4-三唑和1,3,4-噻二唑衍生物
摘要:通过4-取代基的环化合成许多4-取代的3-氨基-5-巯基-1,2,4-三唑和2-氨基-5-烷基(或芳基)氨基-1,3,4-噻二唑. 1-Ami基硫代氨基脲分别在碱性或酸性介质中.在这些合成所需的中间体中,描述了三种异构体(三氟甲基)苯基-硫脲.
Doi:10.1016/s0040-4020(01)99234-8

专利信息

专利号:US-6136984-A
优先权日:1996-04-22
标 题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest is disclosed. The thiophenes are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegier-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:WO-9700244-A1
优先权日:1995-06-19
标题 :Process for parallel synthesis of a non-peptide library
发明人：FRITZ JAMES E; KALDOR STEPHEN W
权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W
摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.

专利号:WO-9740034-A1
优先权日:1996-04-22
标题:Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes

专利号:EP-1021435-A1
优先权日:1996-04-22
标题:Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes

专利号:US-8372971-B2
优先权日:2004-08-25
标 题:Heterocyclic compounds and methods of use
发明人：WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

专利号:WO-9700872-A1
优先权日:1995-06-23
标题 :1,3,8-triaza- and 3,8-diaza-1-oxaspiro(4,5)decane derivatives
发明人：BERGER JACOB; CARTER DAVID SCOTT; FLIPPIN LEE ALLEN; WEINHARDT KLAUS KURT
权利人:HOFFMANN LA ROCHE
摘要:Heterocyclic compounds of Formula (I) in which n is 2, 3, 4, 5 or 6; t is 1, 2, 3 or 4; u is 0 or 1 (provided that t is not 1 when u is 0); X is O or N(R4), in which R4 is hydro, (C¿1-4?)alkyl, or aryl; Y and Z are independently C(O), C(S) or CH2 (provided that Y and Z are not both CH2); R?1, R2, and R3¿ are as defined in the specification; and their pharmaceutically acceptable salts and N-oxides, formulations containing them, their uses as therapeutic agents, and their synthesis. The compounds of this invention are selective 5-HT¿2?C receptor antagonists.