CAS: 16713-66-9; 2,2-(Cyclopentane-1,1-Diyl)Diacetic Acid

该化合物是一种环球二叶酸,其特点是独特的环戊烷脊椎,在1号位置有两个乙酸替代成分.这种结构具有僵硬性和功能性多功能性,在有机合成和制药中间应用中具有价值.它的双色碳烯基组可以参与凝结,酯化和恐吓反应,便利复杂的分子框架的构建.环戊烷环在保持回活动的同时增强稳定性,在相容限制和合成灵活性之间保持平衡.该化合物特别有助于开发成形和小颗粒抑制剂,其结构特征有助于改善结合性和代谢稳定性.对于受控反应来说,它经常用于精细的化学和药用化学研究.

结构式图片

相似化合物

1123-00-8 3187-32-4 933-47-1

欧盟法规

ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

    1-(环戊烯-1-基)丙烷-2-酮置于barium Dihydroxide,Sodium Hypobromide,乙醇体系中,化学反应生成1,1-环戊烷二乙酸
    参考文献:Norris; Thorpe,Journal Of The Chemical Society,1921,Vol. 119,P. 1206
    标题:Norris; Thorpe,Journal Of The Chemical Society,1921,Vol. 119,P. 1206

    海关参考信息

    专利信息


    专利号:US-6177572-B1
    优先权日:1997-08-20
    标题 :Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use
    发明人:WANG FENGJIANG
    权利人:SEPRACOR INC
    摘要:Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed.

    专利号:US-6872856-B2
    优先权日:2000-06-28
    标 题 :Cyclic ketones, their preparation and their use in the synthesis of amino acids
    发明人:BLAKEMORE DAVID CLIVE; BRYANS JUSTIN STEPHEN
    权利人:WARNER LAMBERT CO
    摘要:A method is provided for making an enantiomerically pure compound of the formula: in which R and R′ represent C1?C10 alkyl, C2?C10 alkenyl or C3?C10 cycloalkyl and the wedges signify (S)- or (R)-stereochemistry, the substituents in compound (II) being trans. Conjugate addition is carried out between an organometallic nucleophile that provides a group R as defined above and (R)-4-acetoxycyclopent-2-en-1-one, (S)-4-acetoxycyclopent-2-en-1-one or a similar compound in which acetoxy is replaced by another leaving group to give, e.g. in the case of the acetoxy compound, a trans 3,4-disubstituted addition product of formula III or IV; The acetyl group is eliminated from the addition product to give an (R)- or (S)-4-alkyl or 4-alkenyl cyclopent-2-en-1-one the compound of formula is then to be hydrogenated to give a cyclopentanone of formula (I) or conjugate addition of a second organometallic nucleophile that provides a group R′ as defined above to the compound of the above formula may be carried out to give a trans 3,4-disubstituted addition product of formula (II). One of the above compounds may be converted e.g. via an intermediate (XV)-(XVIII) (in which the substituents R and R′ and the wedges have the meanings indicated above) to a gabapentin analogue of one of the formulae shown below: in which the substituents R and R′ and the wedges also have the meanings indicated above.

    专利号:US-2022010060-A1
    优先权日:2018-12-12
    标题:Polycarbonate polyols
    发明人:FENG XIAOSHUANG; PATIL NAGANATH; BOOPATHI Senthil; GNANOU YVES; HADJICHRISTIDIS NIKOS
    权利人:UNIV KING ABDULLAH SCI & TECH
    摘要:Embodiments of the present disclosure describe polymerization systems for the synthesis of polycarbonate polyols, methods of synthesizing polycarbonate polyols using the polymerization systems, methods of recovering initiators and/or activators for use or re-use in the synthesis of polycarbonate polyol, and the like. The polymerization systems can comprise an initiator including a mono- or multi-functional carboxylate or carbonate salt having an organic cation as a counter-ion; an optional co-initiator including a mono- or multi-functional protic compound selected from acids, alcohols, water, and combinations thereof; and an activator including a borane compound selected from alkyl boranes and aryl boranes; wherein the activator and one or more of the initiator and co-initiator associate to form an ate complex.

    专利号:US-2003187296-A1
    优先权日:2000-06-28
    标题 :Cyclic ketones, their preparation and their use in the synthesis of amino acids

    专利号:US-4810778-A
    优先权日:1986-01-16
    标 题 :Intermediates for preparing 1,6-dicarba-vasopressin compounds
    发明人:CALLAHAN JAMES F; HUFFMAN WILLIAM F; NEWLANDER KENNETH A; YIM NELSON C F
    权利人:SMITHKLINE BECKMAN CORP
    摘要:New compounds which have potent V2-vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by the Pas1,6 or Tas1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.

    专利号:US-4760052-A
    优先权日:1986-01-16
    标 题 :1,6-dicarba-vasopressin compounds
    发明人:CALLAHAN JAMES F; HUFFMAN WILLIAM F; NEWLANDER KENNETH A; YIM NELSON C F
    权利人:SMITHKLINE BECKMAN CORP
    摘要:New compounds which have potent V2-vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas1,6 or Tas1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
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    主要参考文献

    [参考文献]: Do Thi Ha, Et Al. Inhibitors Of Aldose Reductase And Formation Of Advanced Glycation End-Products In Moutan Cortex (Paeonia Suffruticosa). J Nat Prod. 2009 Aug;72(8):1465-70.
    [参考文献]: J May, Et Al. Glucose Increases Spontaneous Platelet Aggregation In Whole Blood. Thromb Res. 1990 Aug 1;59(3):489-95.
    [参考文献]: L Agius, Et Al. Control Of Glucokinase Translocation In Rat Hepatocytes By Sorbitol And The Cytosolic Redox State. Biochem J. 1994 Feb 15;298 ( Pt 1)(Pt 1):237-43.
    [参考文献]: M Schmidt, Et Al. Inhibition Of Sorbitol Formation In Human Erythrocytes By Calcium Dobesilate. Arzneimittelforschung. 1989 Apr;39(4):493-5.
    [参考文献]: S Liu, Et Al. The Distribution Of Aldose Reductase And Aldehyde Reductase Ii In Different Regions Of Bovine Lens. Lens Eye Toxic Res. 1989;6(3):415-30.

    合成参考文献


    摘要:Kostikov, R. R.; Khlebnikov, A. F.; Sokolov, V. V., Science of Synthesis, (2010) 47, 780.
    参考文献:10.1002/jssc.200900693
    摘要:Lee J, Jang DS, Yoo NH, Lee YM, Kim J, Kim JS. Single‐step separation of bioactive flavonol glucosides from Osteomeles schwerinae by high‐speed counter‐current chromatography. J of Separation Science. 2010 Mar;33(4-5):582–6. doi: 10.1002/jssc.200900693.
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