CAS: 1519-39-7; (R)-1-Methyl-4-(Methylsulfinyl)Benzene

相似化合物

934-72-5 5056-07-5 1193-82-4

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📜4-甲基茴香硫醚置于dl-Dithiothreitol,双氧水,Curvularia Inaequalis Vanadium Chloroperoxidase,E. Coli K-12 Methionine Sulfoxide Reductase A体系中,用 Aq. Phosphate Buffer,乙腈 用作溶剂,化学反应 7.5H,反应生成(R)-(+)-甲基对甲苯砜
参考文献:氧化还原酶级联合成对映体富集的亚砜
标题:氧化还原酶级联合成对映体富集的亚砜
摘要:线性氧化还原双酶级联设计用于从硫化物开始合成手性亚砜.组合级联产生了范围广泛的结构多样的亚砜,具有优异的光学纯度 (>99 % Ee),具有互补的手性.该级联结合了ci Vcpo 的卓越稳定性和 Msra/msrb 的对映选择性,因此,它不仅使ci Vcpo 在手性亚砜合成中获得相关性,而且为 ( S )-硫化物的合成提供了强有力的途径.
Doi:10.1002/chem.202201997

专利信息

专利号:US-8153361-B1
优先权日:2006-02-06
标题:Dynamic and combinatorial synthesis of polymerase primers
发明人：BENNER STEVEN ALBERT
权利人:BENNER STEVEN ALBERT
摘要:This invention relates to the field of nucleic acid chemistry, more specifically to compositions of matter that are nucleic acid analogs, and processes that use them. Still more specifically, these compositions comprise two fragments of DNA-like molecules, each having one or more ends modified to carry a reactive group, where the reactive group on one fragment can form a transient covalent bond with the reactive group on the other under conditions of dynamic equilibrium to form a composite, where the composite can then bind to a target oligonucleotide, such as a DNA or RNA molecule. Most specifically, once the transient covalent bond forms, the composite serves as a primer for a template-directed polymerization using a DNA polymerase, an RNA polymerase, or a reverse transcriptase. Once incorporated, the epimerization causes the base pair to be destabilized, the duplex containing the epimerized nucleoside to likewise be destabilized, and the double strand to then disassociate. This leaves the template available to template the synthesis of another complementary oligonucleotide containing the epimerizing base.

专利号:US-2011130578-A1
优先权日:2009-06-03
标题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：FANDRICK DANIEL R; KUZMICH DANIEL; REEVES JONATHAN T; SONG JINHUA J; TAN ZHULIN; LEE THOMAS
权利人:BOEHRINGER INGELHEIM INT
摘要:A process for stereoselective synthesis of a compound of Formula (X) or Formula (X′) n n n n n n n n n n wherein:n R 1 is an aryl group substituted with one to three substituent groups,n wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, C 2 -C 5 alkenyl, C 2 -C 5 alkynyl, C 1 -C 5 alkoxy, C 1 -C 5 alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, C 1 -C 5 alkoxycarbonylamino, aminosulfonyl, C 1 -C 5 alkylaminosulfonyl, C 1 -C 5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, nitro, or C 1 -C 5 alkylthio wherein the sulfur atom is oxidized to sulfoxide or sulfone, and n R 2 and R 3 are each independently hydrogen or C 1 -C 5 alkyl.

专利号:US-7256300-B2
优先权日:2004-03-30
标 题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：LEE THOMAS WAI-HO; PROUDFOOT JOHN ROBERT
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (X) or Formula (X′) n nwherein R 1 , R 2 , and R 3 are as defined herein, the process comprising:n (a) reacting the starting material of formula A with a chiral sulfoxide anion source in a suitable solvent to prepare a compound of formula C or C′; (b) reducing the sulfoxide of formula C or C′ in a suitable solvent to obtain the compound of formula D or D′; and (c) cyclizing the compound of formula D or D′ in a suitable solvent to form the epoxide compound of Formula (X) or Formula (X′),n nor a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

专利号:US-7321070-B2
优先权日:2003-07-30
标题:Synthesis of isotopically labeled R- or S-[13C, 2H] glycerols
发明人：MARTINEZ RODOLFO A; UNKEFER CLIFFORD J; ALVAREZ MARC A
权利人:LOS ALAMOS NAT SECURITY LLC
摘要:The present invention is directed to asymmetric chiral labeled glycerols including at least one chiral atom, from one to two 13 C atoms and from zero to four deuterium atoms bonded directly to a carbon atom, e.g., (2S) [1,2- 13 C 2 ]glycerol and (2R) [1,2- 13 C 2 ]glycerol, and to the use of such chiral glycerols in the preparation of labeled amino acids.

专利号:US-6417374-B1
优先权日:2001-02-15
标题 :Process for the preparation of beta hydroxy-delta lactone using novel intermediates
发明人：GHORPADE SANDEEP RAGHUNATH; KALKOTE UTTAM RAMRAO; CHAVAN SUBHASH PRATAPRAO; BHIDE SUNIL RAMCHANDRA; RAVINDRANATHAN THOTTAPPILLIL
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a process for the preparation of optically active 6-hydroxymethyl-4-(tert-butyldimethylsilyloxy)-(4R,6S)-tetrahydro-2H-2-pyranone(β-Hydroxy-δ-lactone) an important intermediate in the synthesis of biologically active drugs e.g. compactin, atorvastatin, fluvastatin, cholesterol lowering drugs.

专利号:US-2005234250-A1
优先权日:2004-03-30
标题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols