CAS: 14918-80-0; 3-Methyl-4-Oxobut-2-En-1-Yl Acetate

上下游产品

CAS号27231-36-3 2-巯基-5-甲基苯并咪唑 | CAS号127-47-9 维生素A醋酸酯

📜1-氯-3-甲基-3-丁烯置于氧气体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,60.0~300.0 °C,50.0 Kpa 条件下,反应 6.0H,反应生成3-甲酰基丁-2-烯基乙酸酯
参考文献:一种4-乙酰氧基-2-甲基-2-丁烯醛的制备方法
标题:一种4-乙酰氧基-2-甲基-2-丁烯醛的制备方法
摘要:本发明提供了一种4‑乙酰氧基‑2‑甲基‑2‑丁烯醛的制备方法.该方法包含如下步骤:(1)异戊烯氯在催化剂作用下被氧气氧化为4‑氯‑2‑甲基‑2‑丁烯醛;(2)4‑氯‑2‑甲基‑2‑丁烯醛与醋酸盐反应得到4‑乙酰氧基‑2‑甲基‑2‑丁烯醛.所述方法的起始原料异戊烯氯廉价易得,工艺路线短,方法经济有效.

专利信息

专利号:US-9040742-B2
优先权日:2011-12-27
标题:Catalytic synthesis of vitamin A intermediate
发明人：BONRATH WERNER; WUESTENBERG BETTINA; NETSCHER THOMAS; SCHUETZ JAN
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a process of production of a compound, which is useful as an intermediate (building block) in organic synthesis, especially in the synthesis of vitamin A or β-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin.

专利号:US-4206153-A
优先权日:1977-12-17
标 题 :Treatment of methanolic-aqueous residues from syntheses employing triphenylphosphonium salts
发明人：GRAFEN PAUL; SCHOLZ HANS-ULRICH; SCHULZ BERNHARD
权利人:BASF AG
摘要:A process for treating residues which result from the Wittig synthesis of olefins and which consist principally of methanol, triphenylphosphine oxide, salts and organic by-products, by steam-stripping the volatile constituents, with partial condensation of the steam, and separating the resulting aqueous-organic mixture at 80 DEG -100 DEG C. into a saline aqueous phase and an organic phase containing principally triphenylphosphine oxide. Using this process provides a simple method of freeing, from triphenylphosphine oxide and other organic impurities, the effluent from syntheses which result in the formation of triphenylphosphine oxide, and thereby on the one hand substantially facilitates the purification of the effluent and on the other hand provides a simple method of recovering the triphenylphosphine oxide. The latter compound, which is easily purified by distillation or recrystallization, can then be used, for example, to prepare the triphenylphosphine required for Wittig syntheses or to prepare the triphenylphosphine dichloride required for the synthesis of pesticides.

专利号:US-4301084-A
优先权日:1979-08-31
标 题 :Process for the preparation of carboxylic acid esters of β-formyl-crotyl alcohol by an allyl rearrangement
发明人：LAAS HARALD; NISSEN AXEL; MEISSNER BERND
权利人:BASF AG
摘要:In a process for the preparation of a carboxylic acid ester of beta -formyl-crotyl alcohol by rearrangement of the corresponding carboxylic acid ester of 2-formyl-2-hydroxy-but-3-ene or of an acetal or acylate thereof in the presence of copper or a copper compound, followed, where relevant, by hydrolytic cleavage of the acetal or acylate, more especially in the preparation of 4,4-dimethoxy-3-methyl-crotyl acetate, the yield is improved by carrying out the rearrangement in the presence of copper (I) chloride as the catalyst and ensuring that low-boiling by-products formed during the rearrangement are removed. The products are of great importance as starting materials for an industrial synthesis of vitamin A and its derivatives.

专利号:US-2025296906-A1
优先权日:2022-08-24
标 题 :Method for preparing 4-hydroxy-2-methylene-butanal, 4-hydroxy-2-methyl-but-2-enal and esters thereof
发明人：SCHAEFER BERND; SIEGEL WOLFGANG
权利人:BASF SE
摘要:The present invention relates to a method for preparing 4-hydroxy-2-methylene-butanal, 4-hydroxy-2-methyl-but-2-enal and esters thereof of the formula (I.a) and (I.b) where R1 is as defined in the claims and the description, by subjecting isoprenol or an ester thereof to a photooxidation in the presence of a photosensitizer and an acylating agent. The invention relates moreover to certain hydroperoxides of the compounds (I.a) or (I.b), and to the use thereof as intermediates in the synthesis of compounds (I.a) and (I.b) or in the synthesis of retinol, stereoisomers and derivatives thereof.

专利号:US-9187394-B2
优先权日:2011-12-26
标题:Method for synthesizing 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde
发明人：LV CHUNLEI; PI SHIQING; CHEN JIANHUI; LU DINGQIANG; OUYANG PINGKAI
权利人:NANJING UNIVERSITY OF TECHNOLOGY; ZHEJIANG MED XINCHANG PHARM
摘要:Provided in the present invention is a method for synthesizing 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde. The synthesis method comprises the following steps: (1) adding acetaldehyde diethyl acetal and ethyl-(1-propenyl)-ether under the effect of a catalyst to produce 1,1,3-triethoxy-2-methyl-butane; (2) pyrolysis synthesizing 1,1,3-triethoxy-2-methyl-butane under the catalytic effects of isoquinoline and p-Toluenesulfonic acid to produce 1-methoxy-2-methyl-1,3-butadiene; (3) dissolving 1-methoxy-2-methyl-1,3-butadiene in anhydrous ethanol solvent for synthesis with a phase transfer catalyst, cetyl-trimethyl ammonium bromide, and a chlorinating agent, trichloroisocyanuric acid, to generate 4,4-diethoxy-3-methyl-1-chloro-butene; (4) combining 4,4-diethoxy-3-methyl-1-chloro-butene with a triphenylphosphine salt to produce a phosphonium salt; and (5) condensing the phosphonium salt under the effects of hydrogen peroxide in conjunction with sodium carbonate solution to generate 1,1,8,8-tetramethyl-2,7-dimethyl-2,4,6-octatriene; then hydrolyzing under acidic conditions to synthesize 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde. The present invention has a simple process route, is easy to operate, and has mild conditions, great yield, and great industrial value.

专利号:US-7323589-B2
优先权日:2000-10-26
标 题:Intermediates for use in retinoid synthesis
发明人：VALLA ALAIN; CARTIER DOMINIQUE; LABIA ROGER; POTIER PIERRE JEAN-PAUL
权利人:CENTRE NAT RECH SCIENT
摘要:The invention concerns compounds of formula (1) wherein in particular G represents the —N(CH 3 ) 2 —, —N(C 2 H 5 ) 2 -group or N-pyrrolidine: n is an integer equal to 1 or 2: R 1 , R 2 and R 3 , independently of one another, represent a hydrogen atom or a methyl group, the successive unsaturated units capable of being moreover identical or different, provided that at least one of the substituents R 1 , R 2 and R 3 is different from H: and Y 1 and Y 2 represent each a —COOCH 3 group or a COOC 2 H 5 group.