CAS: 14128-54-2; Lithium Aluminum Deuteride

专利信息

专利号:US-12234200-B2
优先权日:2019-04-16
标 题:Synthetic methods of preparing esketamine
发明人：CHEN CHENG YI
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to methods for the asymmetric synthesis of esketamine. The present invention is further directed to key intermediates in the asymmetric esketamine synthesis. In one embodiment, the invention is an asymmetric synthesis of esketamine comprising the conversion of (S)-2′-chloro-2-methoxy-3,4,5,6-5 tetrahydro-[1, 1′-biphenyl]-3-yl carbamate to (S)-2′-chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1′-biphenyl.

专利号:US-2024010638-A1
优先权日:2020-11-13
标题:Improved synthesis of crac channel inhibitors
发明人：STAUDERMAN KENNETH; DUNN MICHAEL; OLMSTEAD KAY
权利人:CALCIMEDICA INC
摘要:Provided herein is an improved synthetic method for the production of CRAC channel inhibitors. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.

专利号:US-2022056053-A1
优先权日:2019-05-06
标 题:Synthesis of crac channel inhibitors
发明人：STAUDERMAN KENNETH A; DUNN MICHAEL; WHITTEN JEFFREY P; ROGERS EVAN
权利人:CALCIMEDICA INC
摘要:A convergent synthetic method for the production of CRAC channel inhibitors is described herein. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.

专利号:US-2025026733-A1
优先权日:2022-03-24
标题 :Deuterated analogs of pyrole inhibitors of erk, synthesis thereof and intermediates thereto
发明人：DECRESCENZO GARY; TERESK MARTIN
权利人:BIOMED VALLEY DISCOVERIES INC
摘要:The present disclosure provides, inter alia, deuterated analogs of ulixertinib and pharmaceutically acceptable salts thereof, which are effective inhibitors of ERK protein kinases and have surprisingly improved pharmacokinetic and metabolite formation properties. The present disclosure also provides, inter alia, methods of making and using same. Kits containing compounds and pharmaceutical compositions of such deuterated analogs are also provided.

专利号:EP-3966215-B1
优先权日:2019-05-09
标 题 :Synthesis of labeled imidazo[1,2-a]pyrimidines

专利号:US-2024217929-A1
优先权日:2019-11-07
标题:Synthesis of n,n-dimethyltryptamine-type compounds, methods, and uses