CAS: 134179-40-1; 2,2,3,3-Tetramethyl-4,7,10,13-Tetraoxa-3-Silapentadecan-15-Ol

该化合物是一种基于聚乙烯甘醇(PEG)的链接,其特点是以一端和氢氧(OH)为组群的保护基-丁二甲基硅基(TBDMS),TBDMS组提供了稳定性和选择性的脱保能力,使其在有机合成和生物协同应用中有用.PEG4空间仪提高了溶性和灵活性,便利了功能组间有节制的间隔.这种复合物在peptide 和 oligonucluotide 合成中特别有用,其中保护组战略和水文生物联系器至关重要.其明确界定的结构和与标准的混合试剂的兼容性确保了复杂的分子组群的可靠性能.该产品通常用于......

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112-60-7 201037-95-8 131326-39-1

欧盟法规

C&L通报

上下游产品

Tetraethylene glycol tert-butyldimethylsilyl chloride toluene-4-sulfonic acid 2-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethoxy]ethoxy}ethoxy)ethyl ester tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-2,5-diiodo-benzene1,4-bis-[2-(2-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-2,5-diiodo-benzene malonic acid bis(4-nitro-phenoxycarboxylate-tetraethyleneglycol)ester tert-butyl 14-hydroxy-3,6,9,12-tetraoxatetradecan-1-oate

合成工艺路线路线简述

  • 合成目标产物 2-[2-[2-[2-[(Tert-Butyldimethylsilanyl)Oxy]Ethoxy]Ethoxy]Ethoxy]Ethanol 主要起始原料 Tert-Butyldimethylsilyl Chloride
  • (文献来源)合成步骤主要原料 Tert-Butyldimethylsilyl Chloride
📜叔丁基二甲基氯硅烷置于咪唑体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 2.5H,以61%的收率获得13,13,14,14-四甲基-3,6,9,12-四氧杂-13-硅-1-十五醇
参考文献:Wo2006/77597
标题:Wo2006/77597

海关参考信息

专利信息


专利号:US-8252778-B2
优先权日:2006-03-24
标题:Highly fluorinated oils and surfactants and methods of making and using same
发明人:YU YIHUA; JIANG ZHONG-XING
权利人:YU YIHUA; JIANG ZHONG-XING; UNIV UTAH RES FOUND
摘要:Disclosed are compounds comprising the structure: n nIn one aspect, the compounds exhibit maximum symmetric branching. Also disclosed are bilayers, micelles, coatings, and nanoparticles comprising the disclosed compounds. Also disclosed are processes for the preparation of the disclosed compounds and methods of using the disclosed compounds. Also disclosed are highly fluorinated dendrons and methods for making same. Also disclosed are methods for Fluorous Mixture Synthesis and tagging. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G. PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Sci Rep. 2016 Aug 30;6:31750. doi: 10.1038/srep31750.
2: Saifer MG, Williams LD, Sobczyk MA, Michaels SJ, Sherman MR. Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins. Mol Immunol. 2014 Feb;57(2):236-46. doi: 10.1016/j.molimm.2013.07.014. Epub 2013 Nov 5. doi: 10.1517/17425247.2012.720969. Epub 2012 Aug 30.

合成参考文献

参考DOI号:10.1021/jm301040s
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