CAS: 123748-68-5; (2S,3S,4S,5R,6R)-6-(((3S,4S,4Ar,6Ar,6Bs,8R,8Ar,9R,10R,12As,14Ar,14Br)-9-Acetoxy-8-Hydroxy-4,8A-Bis(Hydroxymethyl)-4,6A,6B,11,11,14B-Hexamethyl-10-(((E)-2-Methylbut-2-Enoyl)Oxy)-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,14,14A,14B-Icosahydropicen-3-yl)Oxy
该化合物是一种来自马栗树(Aesculus hippocastanum)种子的三联苯沙邦素,其特点是结构复杂,包括类固醇的脊椎和糖糖糖.Esciin Ia展示了一系列生物活动,包括抗炎,抗氧化剂和血清特性,使其对药理学和化妆应用都感兴趣.它经常用于旨在改善毒气循环和减少水肿的配方.该物质溶于水和有机溶剂,可增强其多种配方的多功能性.此外,对Escin Ia进行了研究,以了解其在诸如慢性肠胃不适和肝炎等条件下的潜在治疗效应.安全剖面图显示,该物质一般都受到很好的调适,但有些人可能受到温和的胃肠道干扰.
- 英文名称(2S,3S,4S,5R,6R)-6-(((3S,4S,4Ar,6Ar,6Bs,8R,8Ar,9R,10R,12As,14Ar,14Br)-9-Acetoxy-8-Hydroxy-4,8A-Bis(Hydroxymethyl)-4,6A,6B,11,11,14B-Hexamethyl-10-(((E)-2-Methylbut-2-Enoyl)Oxy)-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,14,14A,14B-Icosahydropicen-3-yl)Oxy
- 中文名称七叶皂苷 A
- IUPAC名称(2S,3S,4S,5R,6R)-6-(((3S,4S,4aR,6aR,6bS,8R,8aR,9R,10R,12aS,14aR,14bR)-9-acetoxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-(((E)-2-methylbut-2-enoyl)oxy)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy)-4-hydroxy-3,5-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
- 其它别名Alpha-Aescusan; Alpha-Reparil; Escin Ia; Unii-Lb5Djt9Fiw; Escin Alpha-Escin [mi]; .Alpha.-Escin; Beta-Escin; .Beta.-D-Glucopyranosiduronic Acid, (3.Beta.,4.Beta.,16.Alpha.,21.Beta.,22.Alpha.)-22-(Acetylo
- CAS编号123748-68-5
- MFCD编号:MFCD10566608
- EINECS号:683-254-0
- 分子式:C55H86O24分子量:1131.27
- 产品CID: 342244
- 产品分类生物化工 → 植物提取物
物理性质
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
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主要参考文献
1: Sun Y, Zhang X, Shen X, Wang S, Wang Q, Yang X. Computational and experimental characterization of isomers of escin-induced renal cytotoxicity by inhibiting heat shock proteins. Eur J Pharmacol. 2021 Jul 27;908:174372. doi: 10.1016/j.ejphar.2021.174372. Epub ahead of print. 26(13):3784. doi: 10.3390/molecules26133784.
4: Hess S, Pouzat C, Paeger L, Pippow A, Kloppenburg P. Analysis of neuronal Ca2+ handling properties by combining perforated patch clamp recordings and the added buffer approach. Cell Calcium. 2021 May 10;97:102411. doi: 10.1016/j.ceca.2021.102411. Epub ahead of print. 9(1):26-30. doi: 10.4103/JMAU.JMAU_56_19.
6: Omi K, Matsuo Y, Ueda G, Aoyama Y, Kato T, Hayashi Y, Imafuji H, Saito K, Tsuboi K, Morimoto M, Ogawa R, Takahashi H, Takiguchi S. Escin inhibits angiogenesis by suppressing interleukin‑8 and vascular endothelial growth factor production by blocking nuclear factor‑κB activation in pancreatic cancer cell lines. Oncol Rep. 2021 May;45(5):55. doi: 10.3892/or.2021.8006. Epub 2021 Mar 24.
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