CAS: 1181-54-0; Clomocycline

该化合物是一种属于四环乙烷类的合成抗生素,其特点是其广泛频谱抗菌活动,主要有效防治各种抗菌性细菌,使其在治疗各种感染方面有用;该化合物展示了一种行动机制,它涉及通过与30S 脊髓炎亚细胞结合,抑制细菌蛋白合成,从而防止 mRNA的转化;在出现气态酸的情况下,氯环乙烷因其稳定性而闻名,这种酸在口服时可提高其生物利用率;此外,它具有防炎特性,可以有助于治疗细菌感染以外的情况;然而,与其他四环乙烷一样,三氯环乙烷可能会产生副作用,如胃肠扰动,光敏度以及对儿童骨骼发育的潜在影响;必须明智地使用这种抗生素,以尽量减少抗生素抗药性的风险;与任何药物一样,至关重要的是遵循适当的准则,并咨询保健专业人员在特定临床情况下使用.

结构式图片

物理性质

MSDS等安全信息

    合成工艺路线路线简述

      海关参考信息

      专利信息


      专利号:US-10472663-B2
      优先权日:2015-01-21
      标 题:Procedure for the rapid determination of bacterial susceptibility to antibiotics that inhibit protein synthesis
      发明人：FERNÃ?NDEZ GARCÃ?A JOSÉ LUIS; GOSÃ?LVEZ BERENGUER JAIME; BOU ARÉVALO GERMÃ?N; TAMAYO NOVAS MARIA; SANTISO BRANDARIZ REBECA; OTERO FARIÑA FÃ?TIMA MARÃ?A
      权利人:ABM TECH LLC
      摘要:The present invention relates to a method for the rapid evaluation of bacterial susceptibility or non-susceptibility of bacteria to antibiotics that inhibit protein synthesis. The rationale is to identify bacterial responses that depend or are influenced by protein synthesis. If this response is prevented or reduced by the antibiotic that inhibits the protein synthesis, the bacteria are susceptible to this antibiotic. Otherwise, if the response keeps similar despite the incubation with the antibiotic, the bacteria are not susceptible or resistant to this antibiotic. These responses could be determined at the DNA lev-el, cell wall level, morphological level or any other experimental approach, including metabolic, bio-chemical, physiological or genetic processes.

      专利号:US-9149445-B2
      优先权日:2009-07-27
      标 题:Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections
      发明人：LIU SEAN; RABINOWITZ JOSHUA D; SHENK THOMAS
      权利人:LIU SEAN; RABINOWITZ JOSHUA D; SHENK THOMAS; UNIV PRINCETON
      摘要:A method of treating or preventing a viral infection in a mammal by administering a compound or pharmaceutically acceptable derivative thereof that inhibits a phosphatidic acid synthesis enzyme.

      专利号:ES-2710679-T3
      优先权日:2015-01-21
      标 题:Procedure for the rapid determination of bacterial susceptibility to antibiotics that inhibit the synthesis of proteins

      专利号:EP-3048174-A1
      优先权日:2015-01-21
      标 题:Procedure for the rapid determination of bacterial susceptibilty to antibiotics that inhibit protein synthesis

      专利号:EP-3048174-B1
      优先权日:2015-01-21
      标 题 :Procedure for the rapid determination of bacterial susceptibility to antibiotics that inhibit protein synthesis

      专利号:US-2016208307-A1
      优先权日:2015-01-21
      标 题:Procedure for the rapid determination of bacterial susceptibility to antibiotics that inhibit protein synthesis

      其他信息查阅

      供应商参考报价(招募中)

      品牌试剂参考报价(招募中)

      实用工具

      ⚠️全国化工行业净网倡议书
      📋制造商识别码
      📖 海关编码查询
      📝MSDS生成器

      📌 第三方产品分析报告

      ✅ COA系统入驻 | 共享模式

      主要参考文献


      1: Ward JM, Corbett MF, Hanna MJ. A double-blind trial of clomocycline in the treatment of persistent palmoplantar pustulosis. Br J Dermatol. 1976 Sep;95(3):317-22. doi: 10.1111/j.1365-2133.1976.tb07020.x. 45(2):154-6. doi: 10.1136/sti.45.2.154.
      3: Ganpule M. Clomocycline and oxytetracycline in acne vulgaris. Practitioner. 1968 Sep;201(203):479-82. 197(179):362-4. 20(11):576-7. 20(11):573-5. 22(9):397-8. 16(2):127-32. doi: 10.1111/j.1365-2125.1983.tb04975.x.

      合成参考文献


      摘要:Antibiotics: Origin, Nature, and Properties, Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978, 1(501), 1978
      📝 需求与反馈
      尽可能描述清楚需求与问题信息
      ×

      通知