CAS: 1122-56-1; Cyclohexanecarboxamide

上下游产品

methyl cyclohexylcarboxylate methyl cyclohexanecarboximidate hydr°Chloride cyclohexane carbonitrile cyclohexanecarbohydrazideN-cyclohexyl-N-formyl-N'-phenyl-ureaN-cyclohexyl-N-formyl-N'-phenyl-urea cyclohexyl-carbamic acid methyl ester 2-cyclohexylbenzoxazole cyclohexane carbonitrile

环己甲酸置于n,N'-羰基二咪唑,Ammonium Hydroxide体系中,用 乙酸乙酯 用作溶剂,化学反应 0.66H,反应生成环己甲酰胺
参考文献:发现酰基脲作为高选择性小分子 Csf1R 激酶抑制剂
标题:发现酰基脲作为高选择性小分子 Csf1R 激酶抑制剂
摘要:基于在 Deciphera 的开关控制激酶抑制剂专有化合物集合中发现的早期先导结构,并结合药物化学指导的结构活性关系和基于结构的药物设计,确定了一系列基于酰基脲的新型 Csf1R 抑制剂与iii 型受体酪氨酸激酶 (Rtk) 家族成员(kit,Pdgfr-α,Pdgfr-β 和 Flt3),Vegfr2 和 Met 的其他成员相比,对 Csf1R 显示出高选择性.基于体外生物学,体外adme 和体内pk/pd 研究,化合物10被选为 Deciphera 的 Csf1R 研究计划的高级先导.
Doi:10.1016/j.Bmcl.2022.128929

专利信息

专利号:US-4336383-A
优先权日:1980-05-07
标题:1-1-Binaphthyl-4,4',5,5',8,8'-hexacarboxylic acid compounds, method of preparation and use thereof for the synthesis of asymmetric derivatives of 3,4,9,10-perylenetetracarboxylic acid, and for dyeing and printing of textile materials
发明人：VOROZHTSOV GEORGY N; MASANOVA NATALIA N; FELDBLJUM NIKOLAI B; ALEXEEV VASILY I; SHIGALEVSKY VADIM A; SOLOMATIN GEORGY G; SHULEPOVA OLGA I; KHAITUN GALINA G; GORDEEVA NADEZHDA V
权利人:VOROZHTSOV GEORGY N; MASANOVA NATALIA N; FELDBLJUM NIKOLAI B; ALEXEEV VASILY I; SHIGALEVSKY VADIM A; SOLOMATIN GEORGY G; SHULEPOVA OLGA I; KHAITUN GALINA G; GORDEEVA NADEZHDA V
摘要:1,1'-Binaphthyl-4,4',5,5',8,8'-hexacarboxylic acid compounds having the following formula: ##STR1## wherein R 1 is hydrogen, halogen, or alkyl; when X is oxygen, Y is hydrogen, alkyl, a cycloalkyl, or an aryl containing at least one substituent from the group including: halogen, alkyl, or alkoxy, when X is nitrogen, Y is ##STR2## wherein R 2 is hydrogen, halogen, or alkyl; Y being linked to X with the formation of a benzimidazole cycle. n The method for preparing the compounds according to the present invention resides in the treatment of that 1,1'-binaphthyl-4,4',5,5',8,8'-hexacarboxylic acid anhydride with an alkali to give a corresponding salt which is condensed with orthophenylenediamines upon heating at reflux at a pH of from 6.3 to 6.8. The resulting benzimidazole-1,1'-binaphthyl-4,4',5,5',8,8'-hexacarboxylic acid anhydride having the formula: ##STR3## wherein R 1 is hydrogen, halogen, or alkyl, is isolated and condensed with an amine or ortho-phenylenediamines in an excess of the amine, in water or an organic solvent, followed by isolation of the desired product. n The compounds according to the present invention are employed for the synthesis of asymmetric compounds of 3,4,9,10-perylenetetracarboxylic acid, as well as for dyeing and printing of textile materials with the formation, on the material, of asymmetric compounds of 3,4,9,10-perylenetetracarboxylic acid having the following formula: ##STR4## wherein R 1 is hydrogen, halogen, or alkyl; when X is oxygen, Y is hydrogen, alkyl, cycloalkyl, or aryl containing at least one substituent from the group including; halogen, alkyl, or alkoxy, when X is nitrogen, Y is ##STR5## where R 2 is hydrogen, halogen, or alkyl; Y being linked with X to form a benzimidazole cycle. n The compounds according to the present invention dye textile materials to various shades of violet color.

专利号:EP-1724260-B1
优先权日:2005-05-06
标题:Process for the synthesis of (2S, 3aR, 7aS)octahydroindole-2-carboxylic acid and its conversion to trandolapril
发明人：AKHTAR HAIDER; RAMESH BABU POTLURI; VENKATA SUBHRAMANIAN HARIHARAK; HARI PRASSAD KODALI
权利人:SOCHINAZ SA
摘要:The present invention describes a novel method for the synthesis of (2S,3aR,7aS)-octahydroindole-2-carboxylic acid of formula III nusing a new intermediate of formula II nand conversion of the product of formula-III to trandolapril of formula I

专利号:US-9255255-B2
优先权日:2013-03-04
标 题 :Synthesis of linear and branched polymers of polypeptides through direct conjugation
发明人：ALBAYRAK CEM; SWARTZ JAMES R; LU YUAN
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Methods are provided for a one step synthesis of polypeptide polymers or co-polymers. The polymers or co-polymers can be linear or branched. In the methods of the invention, the coding sequence for the polypeptide(s) to be polymerized is altered by introducing one or more codons for an nonnatural amino acid, which coding sequence is then utilized to produce the cognate polypeptide. The nonnatural amino acids are selected to be reactive with each other in a bioorthogonal reaction, and are combined in a conjugation reaction with the desired components of the polymer.

专利号:US-6107495-A
优先权日:1996-07-24
标题:Thienylcyclohexane derivatives for thienylcyclohexyl synthesis
发明人：CAZAUX JEAN-BERNARD; DAFNIET MICHEL; KAMENKA JEAN-MARC; MANGINOT ERIC
权利人:EXPANSIA SA
摘要:PCT No. PCT/FR97/01382 Sec. 371 Date Jan. 19, 1999 Sec. 102(e) Date Jan. 19, 1999 PCT Filed Jul. 24, 1997 PCT Pub. No. WO98/03498 PCT Pub. Date Jan. 29, 1998Novel thienylcyclohexane derivatives of general formula (I), wherein R' is the 2-thienyl or 3-thienyl radical, R is the cyano radical or a radical of formula -C(O)A, and R2'' is a saturated or unsaturated optionally cyclic hydrocarbon radical, or an aryl radical, are disclosed. Methods for preparing said compounds, and the use thereof as novel industrial products for the synthesis of thienylcyclohexyl derivatives, are also disclosed.

专利号:US-2018312463-A1
优先权日:2015-10-22
标题:Synthesis of Cyclohexane Carboxamide Derivatives Useful as Sensates in Consumer Products
发明人：YELM KENNETH EDWARD; WOS JOHN AUGUST; BUNKE GREGORY MARK; FREDERICK HEATH; HAUGHT JOHN CHRISTIAN; HOKE STEVEN HAMILTON; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

专利号:US-6518048-B2
优先权日:2000-04-10
标题:Stereo-specific synthesis of shimikic acid derivatives with improved efficiency
发明人：IDING HANS; WIRZ BEAT; ZUTTER ULRICH
权利人:HOFFMANN LA ROCHE
摘要:The invention provides a multistep synthesis for the preparation of 4,5-diamino shikimic acid derivatives of formula n starting from an isophthalic acid derivative of formula n 4,5-Diamino shikimic acid derivatives are potent inhibitors of viral neuraminidase.