CAS: 1082951-17-4; 2-Amino-1-(4-Fluoro-3-(Trifluoromethyl)Phenyl)Ethan-1-One 4-Methylbenzenesulfonate
该化合物是一种含氟芳香酮衍生物,配有石耳反作用,为合成应用提供了强化溶性与稳定性.氟和三氟甲基组的存在都具有电子抽取特性,使其成为制药和农用化学合成中有价值的中间体.三环盐形式改善了核生殖替代反应的处理和反应.其结构特征促进了选择性功能化,特别是在生物活性化合物的开发中.化合物的纯度和定义明确的晶体形式确保了研究和工业过程的一致性能.在受控制的条件下,它可以用作有机和药用化学的多用途建筑块.
- 英文名称2-Amino-1-(4-Fluoro-3-(Trifluoromethyl)Phenyl)Ethan-1-One 4-Methylbenzenesulfonate
- 中文名称2-氨基-1-(4-氟-3-(三氟甲基)苯基)乙-1-酮 4-甲基苯磺酸盐
- 其它别名2-氨基-1-(3-三氟甲基苯基)乙酮对甲苯磺酸盐; 2-Amino-1-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Ethanone P-Toluenesulfonate Salt
- CAS编号1082951-17-4
- MFCD编号:MFCD17392808
- 分子式:C16H15F4NO4S分子量:393.35
- 产品CID: 119694
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
1000614-08-3 357952-79-5 143654-60-8MSDS等安全信息
上下游产品
2-bromo-1-(4-fluoro-3-(trifluoromethyl)phenyl)ethan-1-one toluene-4-sulfonic acid N-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}isonicotinamide 2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine 4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine acetic acid salt合成工艺路线路线简述
📜4-氟-3-三氟甲基苯乙酰基溴置于sodium Azide,三苯基膦体系中,用 四氢呋喃,水 用作溶剂,化学反应 36.0H,反应生成1-(3-三氟甲基-4-氟苯基)-2-氨基乙酮对甲苯磺酸盐
参考文献:Rapid Development And Scale-Up Of A 1H-4-Substituted Imidazole Intermediate Enabled By Chemistry In Continuous Plug Flow Reactors
标题:Rapid Development And Scale-Up Of A 1H-4-Substituted Imidazole Intermediate Enabled By Chemistry In Continuous Plug Flow Reactors
摘要:The Development Of Reactions In A Continuous Fashion In Plug Flow Tube Reactors (Pfr) Offers Unique Advantages To The Drug Development And Scale-Up Process And Can Also Enable Chemistry That Would Be Difficult To Perform Via Batch Processing. Herein,We Report The Development Of Two Different Continuous Flow Approaches To A Key 1H-4-Substituted Imidazole Intermediate (5). In A First Generation Approach,Rapid Optimization And Scale-Up Of A Challenging Cyclization Reaction Was Demonstrated In A Pfr Under Gmp Conditions To Afford 29 Kg Of Protected Product 2. This Material Was Further Processed In Batch Equipment To Deliver Di-Hcl Salt 4. This First Generation Approach Highlights The Rapid Development Of Chemistry In Research-Scale Pfrs And Speed To Material Delivery Through Linear Scale Up To A Pilot-Scale Pfr Under Gmp Conditions. In A Second Generation Effort,A More Efficient Synthetic Route Was Developed,And Pfrs With Automated Sampling,Dilution,And Analytical Analysis Allowed For Rapid And Data-Rich Reaction Optimization Of Both A Key Cyclization Reaction And Thermal Removal Of A Boc Protecting Group. This Work Culminated In 1 Kg Demonstration Runs In A 0.22 L Pfr For Both Continuous Steps And Shows The Potential Of Commercialization From A Lab Hood Footprint (1-2 Mt/year).
Doi:10.1021/op200351G
专利信息
专利号:US-4460604-A
优先权日:1976-06-03
标 题 :4-Amino-4-aryl-cyclohexanones
发明人：LEDNICER DANIEL
权利人:UPJOHN CO
摘要:A class of 4-amine-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts. Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.
