CAS: 108238-09-1; 2-Phenoxybenzeneboronic Acid

该化合物是一种多用途的boronic酸衍生物,广泛用于铃木-米亚乌拉交叉交错反应,这是有机合成中形成碳-碳联系的关键方法,其稳定的boronic moud mudi和芳香苯氧基组使其成为制药,农用化学品和先进材料的宝贵建筑块.该化合物在普通有机溶剂中表现出良好的溶解性,便于其在同质反应条件下使用.其电子富含性结构增强了催化变异的再活性,使得双性恋和异性恋类工作人员能够高效合成.该产品通常具有较高的纯度,确保敏感应用的可靠性能.建议在惰性条件下适当储存,以保持长期稳定.

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CAS号101-84-8 二苯醚 | CAS号121-43-7 硼酸三甲酯 | CAS号2216-12-8 2-硝基苯基苯基醚 | CAS号2417-10-9 2-羟基二苯醚 | CAS号6738-04-1 2-苯氧基联苯

合成工艺路线路线简述

    📜二苯醚置于正丁基锂,硼酸三甲酯,盐酸体系中,用 四氢呋喃,水 用作溶剂,化学反应 2.5H,反应生成2-苯氧基苯硼酸
    参考文献:Intracellular Calcium Concentration Increase Inhibitors
    标题:Intracellular Calcium Concentration Increase Inhibitors
    摘要:一种含有活性成分的细胞内钙浓度增加抑制剂,其活性成分为(1)由化学式(i)表示的硼化合物.化学式(i)表示的化合物抑制细胞内钙浓度的增加,因此被认为可用作预防和/或治疗血小板聚集,心脑缺血疾病,免疫缺陷疾病,变态反应,支气管哮喘,高血压,脑血管痉挛,各种肾脏疾病,胰腺炎,阿尔茨海默病等的药物.

    专利信息


    专利号:US-8207337-B2
    优先权日:2007-01-29
    标 题:Reagent for organic synthesis reaction containing organic triol borate salt
    发明人:MIYAURA NORIO; YAMAMOTO YASUNORI
    权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD
    摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

    专利号:US-2009069334-A1
    优先权日:2007-08-18
    标题:Pyridazine based alpha-helix mimetics
    发明人:REBEK JR JULIUS; BIROS SHANNON; MOISAN LIONEL; VOLONTERIO ALESSANDRO; MANN ENRIQUE; DALE TREVOR
    权利人:SCRIPPS RESEARCH INST
    摘要:The synthesis of new α-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available building block, 6. These scaffolds may be thought of as synthetic counterparts of amphiphilic α-helices having a “wet face†along one side and a hydrophobic face along the other side of the helix.

    专利号:US-2022204495-A1
    优先权日:2019-05-03
    标题:Inhibiting trabid
    发明人:CAMPBELL ANNE-MARIE; MARCIN Lawrence; KAYSER-BRICKER KATHERINE
    权利人:VALO HEALTH INC; INTEGRAL HEALTH HOLDINGS LLC
    摘要:The present disclosure is directed to compounds of formulas (I)-(VII), which are useful as modulators of TRABID. The compounds are further useful in the inhibition of TRABID and the treatment of diseases or disorders associated with the inhibition of TRABID. For instance, the disclosure is concerned with compounds and compositions for inhibition of TRABID, methods of treating diseases associated with the inhibition of TRABID (e.g., autoimmune inflammatory diseases including, but not limited to, psoriasis), and methods of synthesis of these compounds.

    专利号:CA-2965558-A1
    优先权日:2014-10-30
    标题 :Synthesis of substituted 1h-pyrazolo[3,4-d]pyrimidines

    专利号:EP-3212624-A1
    优先权日:2014-10-30
    标 题 :Synthesis of substituted 1h-pyrazolo[3,4-d]pyrimidines

    专利号:CN-106795124-A
    优先权日:2014-10-30
    标题 :Synthesis of Substituted 1H-pyrazolo[3,4-d]pyrimidines

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Matteson, D. S., Science of Synthesis, (2005) 6, 18.
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