CAS: 92972-48-0; 2,4-Dichlorothiazole-5-Carbaldehyde

该化合物是一种环形结构,含有硫磺和氮原子的杂交有机化合物,在硫和氮原子的2和4个位置上存在两个氯原子,有助于其回作用和各种化学反应的潜在应用. 5个位置的carboxaldhyde功能组增强了其反应性,使其在有机合成中有用,特别是在形成更复杂的分子方面.该化合物一般是一种在室温中具有固体性,在极地有机溶剂中可能表现出中等溶性.其独特的结构允许其参与核分裂性添加反应,并且也可以作为合成农用化学或药物的中间体.安全数据表明,与许多氯化化合物一样,应对它时,应谨慎地考虑到潜在的毒性和环境关切.适当的储存和处理程序对于减轻与接触有关的风险至关重要.

英文名称2,4-Dichlorothiazole-5-Carbaldehyde
中文名称2,4-二氯噻唑-5-甲醛
IUPAC名称2,4-dichlorothiazole-5-carbaldehyde
其它别名2,5-二氯噻唑-4-甲醛; 5-Thiazolecarboxaldehyde, 2,4-Dichloro-
CAS编号92972-48-0
MFCD编号:MFCD00793013
EINECS号:677-386-8
分子式:C4HCl2NOS
分子量:182.02
产品CID: 1968602
产品分类有机原料→分子砌块→芳杂环类化合物→噻唑类化合物

相似结构搜索
产品信息参考;
InChIKey: CFEKBKCGPASOFI-UHFFFAOYSA-N
InChI=1S/C4HCl2NOS/c5-3-2(1-8)9-4(6)7-3/h1H…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS06;
注释: Skull and crossbones
危险类别急性毒性类别3(经口)
严重眼刺激类别2
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Danger(危险)
危险描述H301 |吞咽会中毒.
H319 |造成严重眼刺激.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
防范说明P264-P270-P280-P330-P405-P501
危险等级6.1
UN编号2811.0
危险品标志Xi,Xn
风险等级Irritant
包装等级Ⅲ
安全声明26-36/37/39
危险类别码36/37/38-36-22
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 2,4-Dichloro-5-Thiazolecarboxaldehyde 主要起始原料 2,4-Thiazolidinedione
4303-29-1 = 92972-48-0
反应条件:1.1 Reagents: Phosphorus Oxychloride
标题:Phenyl Thiazolyl Urea And Carbamate Derivatives As New Inhibitors Of Bacterial Cell-Wall Biosynthesis
作者:Francisco,Gerardo D.; Li,Zhong; Albright,J. Donald; Eudy,Nancy H.; Katz,Alan H.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2004 卷标:14(1) 页码:235-238]

2295-31-0 = 92972-48-0
反应条件:1.1 Reagents: Phosphorus Oxychloride; 0 °C; 0 °C -> Rt; 1 H,Rt; 1 H,85 °C; 3.5 H,115 °C; 115 °C -> Rt1.2 Reagents: Water; Cooled
标题:Preparation Of N-(Hetero)Arylpyrrolidine Derivatives Of Pyrazol-4-Ylpyrrolo[2,3-D]Pyrimidines And Pyrrol-3-Ylpyrrolo[2,3-D]Pyrimidines As Janus Kinase Jak1 Inhibitors.
参考文献:World Intellectual Property Organization]

2295-31-0 = 92972-48-0
反应条件:1.1 Reagents: Phosphorus Oxychloride; 1 H,Rt; 1 H,80 - 90 °C; 4 H,90 °C -> Reflux
标题:Synthesis Of A New [3-(4-Chlorophenyl)-4-Oxo-1,3-Thiazolidin-5-Ylidene]Acetic Acid Derivative
作者:Szczepanski,Jacek; Tuszewska,Helena; Trotsko,Nazar
参考文献:Molbank 日期:2020 卷标:(3)]

2295-31-0 = 92972-48-0
反应条件:1.1 Reagents: Phosphorus Oxychloride
标题:Design And Development Of Novel Thiazole-Sulfonamide Derivatives As A Protective Agent Against Diabetic Cataract In Wistar Rats Via Inhibition Of Aldose Reductase
作者:Yin,Liang; Zhang,Mingxue; He,Tiangeng
参考文献:Heterocyclic Communications 日期:2021 卷标:27(1) 页码:63-70]

2295-31-0 = 92972-48-0
反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide; 20 Min,100 °C
标题:Preparation Of Pyrimidine-Thiazolidinone Derivatives For The Treatment And Prevention Type-2 Diabetes And Other Diseases
参考文献:United States]

2295-31-0 = 92972-48-0
反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide; 6 H,Reflux; Reflux -> Rt
标题:Synthesis And Characterization Of Novel 1,3,4-Oxadiazole Derivatives Containing A 5-(2,4-Dichlorothiazole) Substituent
作者:Ghodsi,Shahram; Pourmand,Sara; Rabiee,Samaneh; Shafiee,Abbas
参考文献:Asian Journal Of Chemistry 日期:2009 卷标:21(2) 页码:1645-1647]

2295-31-0 = 92972-48-0
反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide; 6 H,Reflux; Reflux -> Rt
标题:Synthesis And Characterization Of Some New 1,4-Dihydropyridine Derivatives Containing Dichlorothiazolyl Substituents
作者:Taghi-Ganji,K. M.; Ghodsi,Sh.; Alipour,E.; Amini,M.; Hosseini,M.; Et Al
参考文献:Asian Journal Of Chemistry 日期:2007 卷标:19(4) 页码:2521-2526]

2295-31-0 = 92972-48-0
反应条件:1.1 Reagents: Phosphorus Oxychloride; 6 H,Reflux
标题:The Synthesis And Characterization Of New Asymmetrical Dihydropyridine Derivatives Containing A 2,4-Dichloro-5-Thiazolyl Substituent
作者:Ghodsi,Shahram; Alipour,Eskandar; Amini,Mohsen; Miri,Ramin; Tagi-Ganji,Karim Masoud; Et Al
参考文献:Phosphorus 日期:2006 卷标:181(10) 页码:2435-2444]

2295-31-0 = 92972-48-0
反应条件:1.1 Reagents: Phosphorus Oxychloride; 5 - 10 °C; 1 H,Rt; Rt -> 90 °C; 1 H,80 - 90 °C; 8 H,120 °C; Cooled1.2 Solvents: Water; Cooled
标题:Synthesis,Characterization And Antioxidant Property Of Novel Series Of Thiazole Based Chalcones Carrying Thiophene/furan Derivatives
作者:Nkurunziza,Jean Baptiste; Kalluraya,Balakrishna
参考文献:Indian Journal Of Heterocyclic Chemistry 日期:2016 卷标:26(1-2) 页码:69-74

2,4-噻唑烷二酮置于三氯氧磷体系中,用 N,N-二甲基甲酰胺作为反应溶剂,化学反应生成 2,4-二氯噻唑-5-甲醛
参考文献:Tricyclic Compounds Capable Of Inhibiting Tyrosine Kinases Of The
标题:Tricyclic Compounds Capable Of Inhibiting Tyrosine Kinases Of The
摘要:描述了一种新型的4-取代氨基苯并噻吩\9B3,2-D!嘧啶和4-取代氨基\9B2,3-D!嘧啶表皮生长因子受体家族的酪氨酸激酶抑制剂,以及相应的药物组合物,用于治疗增殖性疾病,如癌症,关节炎中的滑膜潘纳斯侵袭,牛皮癣,血管再狭窄和血管反应生成,此外还可用于胰腺炎和肾病的治疗,以及避孕剂.