CAS: 84676-89-1; (2S,3R,4S,5R)-4,5-Dihydroxy-2-(((2Ar,3R,4S,5As,5Bs,7S,7Ar,9S,11Ar,12As)-4-Hydroxy-3-((2R,5S)-5-(2-Hydroxypropan-2-yl)-2-Methyltetrahydrofuran-2-yl)-2A,5A,8,8-Tetramethyl-7-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetradecahydro-1H,12H-Cyclopenta[a]Cyclopropa[e]Phenanthren-9-yl)Oxy)Tetrahydro-2H-Pyran-3-Yl Acetate
该化合物是一种生物活性沙邦素化合物,产自传统药草Astragalus membranaceus,其特点是四环三叶管结构,以其潜在的药理特性而著称,包括抗炎,抗氧化剂和心脏保护效应.作为二级代谢物,Astragaloside II表现出很高的纯度和稳定性,适合对细胞信号路径和代谢研究进行研究.其分子式(C43H72O15)和明确界定的结构允许精确的分析应用,如HPLC和LC-MS.该化合物通常用于制药和营养学研究,因为它具有潜在的治疗效益,并且与体外和体外体内模型兼容.
- 英文名称(2S,3R,4S,5R)-4,5-Dihydroxy-2-(((2Ar,3R,4S,5As,5Bs,7S,7Ar,9S,11Ar,12As)-4-Hydroxy-3-((2R,5S)-5-(2-Hydroxypropan-2-yl)-2-Methyltetrahydrofuran-2-yl)-2A,5A,8,8-Tetramethyl-7-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetradecahydro-1H,12H-Cyclopenta[a]Cyclopropa[e]Phenanthren-9-yl)Oxy)Tetrahydro-2H-Pyran-3-Yl Acetate
- 中文名称黄芪皂苷 II
- IUPAC名称(2S,3R,4S,5R)-4,5-dihydroxy-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-hydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-7-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-9-yl)oxy)tetrahydro-2H-pyran-3-yl acetate
- 其它别名(3B,6A,16B,20R,24S)-3-((2-O-Acetyl-Beta-D-Xylopyranosyl)Oxy)-20,24-Epoxy-16,25-Dihydroxy-9,19-Cyclolanostan-6-Yl Beta-D-Glucopyranoside
- CAS编号84676-89-1
- MFCD编号:MFCD12546127
- FDA UNII编号:0K5J34DHEN
- 分子式:C43H70O15分子量:827.02
- 产品CID: 1836258
- 产品分类生物化工 → 中草药成分
物理性质
MSDS等安全信息
上下游产品
CAS号84605-18-5 环黄芪醇 | CAS号83207-58-3 黄芪甲苷A(黄芪甲苷 IV)合成工艺路线路线简述
- 84687-43-4 = 84676-89-1 + 86764-11-6 + 84676-88-0 + 84680-75-1
反应条件:1.1 Solvents: Water; 48 H,Rt
标题:Microbial Transformation Of Astragalosides To Astragaloside Iv By Absidia Corymbifera As2
作者:Ye,Li; Et Al
参考文献:Process Biochemistry (Amsterdam 日期:2011 卷标:46(9) 页码:1724-1730
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇
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合成参考文献
参考文献:10.1055/s-2006-957642
摘要:Caliş I, Yürüker A, Taşdemir D, Wright AD, Sticher O, Luo YD, Pezzuto JM. Cycloartane triterpene glycosides from the roots of Astragalus melanophrurius. Planta Med. 1997 Apr;63(2):183–6. doi: 10.1055/s-2006-957642.
参考文献:10.1248/cpb.31.698
摘要:KITAGAWA I, WANG H, SAITO M, TAKAGI A, YOSHIKAWA M. Saponin and sapogenol. XXXV. Chemical constituents of astragali radix, the root of Astragalus membranaceus Bunge. (2). Astragalosides I,II and IV, acetylastragaloside I and isoastragalosides I and II. Chem. Pharm. Bull. 1983;31(2):698–708. doi: 10.1248/cpb.31.698.
参考文献:10.1002/chin.200545195
摘要:Oezipek M, Doenmez AA, Calis I, Brun R, Rueedi P, Tasdemir D. Leishmanicidal Cycloartane‐Type Triterpene Glycosides from Astragalus oleifolius. ChemInform. 2005 Oct 11;36(45). doi: 10.1002/chin.200545195.
参考文献:10.1016/j.jchromb.2017.08.012
摘要:Li X, Pi Z, Liu S, Wang W, Liu Z, Song F. Online monitoring of astragaloside II metabolism using a homemade cultural device coupled with microdialysis and ultra-performance liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 15;1063():141–8. doi: 10.1016/j.jchromb.2017.08.012.
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