CAS: 712-97-0; 6-Nitrobenzo[d][1,3]Dioxole-5-Carbaldehyde

上下游产品

piperonal (E)-4,5-dihydroxy-2,β-dinitrostyrene piperic acid nitric acid Z)-6-nitro-benzo[1,3]dioxol-5-ylmethylene)-2-phenyl-4H-oxazol-5-one4-((Z)-6-nitro-benzo[1,3]dioxol-5-ylmethylene)-2-phenyl-4H-oxazol-5-one cis-stilbene-α-carboxylic acid4',5'-methylenedioxy-2'-nitro-cis-stilbene-α-carboxylic acid cis-α-Phenyl-2-nitro-4,5-methylendioxy-cinnamylsaeure 2-cyano-3ξ-(6-nitro-benzo[1,3]dioxol-5-yl)-acrylic acid anilide

📜胡椒醛置于硝酸体系中,化学反应 4.0H,以60%的收率获得产物6-硝基胡椒醛
参考文献:新型 7-取代 10,11-亚甲二氧基喜树碱衍生物的设计,合成和生物学评价在体外和体内抗耐药性小细胞肺癌
标题:新型 7-取代 10,11-亚甲二氧基喜树碱衍生物的设计,合成和生物学评价在体外和体内抗耐药性小细胞肺癌
摘要:设计,合成和生物学评估了一系列新型 7 取代 10,11-亚甲二氧基喜树碱 (Fl118) 衍生物.所有 Fl118 类似物在体外都显示出显着的细胞毒活性,Ic 50值在纳摩尔范围内,并且比拓扑替康更有效.活性最强的化合物9C对小细胞肺癌(nci-H446,H69,耐药 H69Ar 细胞,耐药 Nci-H446/伊立替康细胞和耐药 Nci-H446/ep 细胞)表现出更显着的抗肿瘤活性)体外.此外,9C还可以诱导小细胞肺癌中caspase-3,Caspase-9和parp等凋亡蛋白的表达.进一步的研究表明,9C通过抑制小细胞肺癌中 Mcl-1,Bcl-2,Xiap 和 Survivin 的表达诱导细胞凋亡.体内 9C也表现出较好的抗肿瘤功效,肿瘤生长抑制率分别为40.4%(0.75 Mg/kg),73.7%(1.5 Mg/kg)和95.5%(3 Mg/kg).值得注意的是,9C在 Nci-H446/伊立替康和
DOI:10.1016/j.Ejmech.2022.114610

专利信息

专利号:US-6683205-B2
优先权日:2001-02-15
标 题 :Synthesis of 2-aryl propenoic acid esters for the production of non-steroidal anti-inflammatory drugs
发明人：HOSSAIN M MAHMUN
权利人:WISYS TECHNOLOGY FOUND INC
摘要:A method of producing a compound of the formula: n and its pharmaceutically acceptable salts, wherein Ar is a substituted or unsubstituted aromatic or heteroaromatic group; comprising: n (1) reacting a compound of the formula: n wherein Ar is as described above, with N 2 CHCOOR, wherein R is alkyl, in the presence of a catalytic amount of a Bronsted acid or Lewis acid to form a compound of the formula: n wherein Ar and R are as described above; and n (2) reacting the compound of formula (II) with a reducing agent in the presence of an alkyl amine to form a compound of the formula: n wherein Ar and R are as described above.

专利号:US-12187735-B2
优先权日:2018-09-17
标 题:Matter of composition, synthesis, formulation and application of FL118 platform positions 7 and 9-derived analogues for treatment of human disease
发明人：LING XIANG; LI QINGYONG; LI FENGZHI
权利人:CANGET BIOTEKPHARMA LLC
摘要:Described herein, are the chemical synthesis, matter of compositions, formulation, function, methods and uses of the FL118 platform Positions 7 and/or 9-derived analogues for treating cancer or other human diseases. Compounds derived from chemical modifications of the FL118 platform are employed alone or in combination with other anti-cancer agents to preclude, eliminate or reverse cancer phenotypes. This invention intends to realize unique personalized cancer treatment (personalized precision medicine) through application of a series of structural relevant individual FL118 platform-derived analogues, which target multiple cellular human disease-relevant proteins and their signaling pathways.

专利号:US-2025092058-A1
优先权日:2018-09-17
标 题 :Matter of composition, synthesis, formulation and application of fl 118 platform positions 7 and 9-derived analogues for treatment of human disease
发明人：LING XIANG; LI QINGYONG; LI FENGZHI
权利人:CANGET BIOTEKPHARMA LLC
摘要:Described herein, are the chemical synthesis, compounds, methods and uses of the fluoroaryl-substituted derivatives at the FL118 position 7, which target multiple cellular human disease-relevant proteins and their signaling pathways.

专利号:US-2007128658-A1
优先权日:2005-11-14
标 题:Fluorescent dyes, methods and uses thereof
发明人：BLACKWELL HELEN E; BOWMAN MATTHEW D
权利人:BLACKWELL HELEN E; BOWMAN MATTHEW D
摘要:The present invention provides a method for identifying and characterizing candidate fluorescent molecules. This method involves the generation of spatially addressed arrays of heterocyclic compounds which are candidate fluorescent molecules. The spatially addressed array can be used to identify fluorescent molecules among the candidate molecules. The spatially addressed array can be used to determine the optical characteristics of one more candidate molecules. The invention also provides methods for making such arrays of heterocyclic compounds. In a specific embodiment, synthetic methods are provided for synthesis of triarylpyridines, particularly unsymmetric triarylpyridines. n preferred embodiments, the present invention provides novel heterocyclic fluorescent compounds having deazalumazine, cyanopyridine or pyrimidine cores. Heterocyclic fluorescent compounds of this invention are useful as dyes to label molecules such as nucleic acids, peptides and proteins, and particularly antibodies. In other embodiments, the novel heterocyclic fluorescent compounds are useful as dyes to label cellular compartments and organelles. The novel heterocyclic fluorescent compounds can also be used as sensors or indicators of specific metal ions, chemical warfare agents and pH.

专利号:US-11040939-B1
优先权日:2020-06-23
标 题 :N-transfer reagent and method for preparing the same and its application
发明人：CHOU HO-HSUAN; LU GUAN-HAN; HSUEH HSIAO-CHIN; HUANG TZU-CHIA
权利人:UNIV NAT CHENG KUNG
摘要:Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): n n n n n n n n n n The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries