CAS: 697300-70-2; 6-Bromo-5-Iodopyridin-3-Ol

该化合物是一种杂环有机化合物,其特点是存在一种以溴和碘原子替代的环,以及一个羟基组.分子结构具有六人组成的含氮芳香环,有助于其基本性和潜在的再活性.溴和碘代基质具有重大的性能和电子效应,影响化合物的再活性和与其他分子的相互作用.这种化合物可能表现出卤化的典型特性,例如脂性增加和核糖基替代反应的潜力.氢氧类可以参与氢的结合,增强极溶剂的溶解性并影响其生物活动.由于这些特征,6-溴-5-碘基苯丙胺-3-醇可能会在医药化学学和农用化学学的开发中找到应用,特别是药物或农用化学学的开发中.这种独特的组合将卤基亚化合物和功能组群作为进一步研究和开发各种化学应用的宝贵化合物.

英文名称6-Bromo-5-Iodopyridin-3-Ol
中文名称6-溴-5-碘吡啶-3-醇
IUPAC名称6-bromo-5-iodopyridin-3-ol
其它别名2-溴-3-碘-5-羟基-吡啶; 6-Bromo-3-Hydroxy-5-Iodopyridine
CAS编号697300-70-2
MFCD编号:MFCD09038023
分子式:C5H3BrINO分子量:299.89
产品CID: 1692816
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: SWETXSHOZHMDJB-UHFFFAOYSA-N
InChI=1S/C5H3BrINO/c6-5-4(7)1-3(9)2-8-5/h1-2,9H
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

相似化合物

55717-45-8 188057-35-4 6602-33-1

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-H335-
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

5-acetoxy-2-bromo-3-iodopyridine 2-hydroxy-3-iodo-5-nitropyridine 5-amino-2-bromo-3-iodopyridine 2-bromo-3-iodo-5-nitropyridine

合成工艺路线路线简述

📜3-碘-2-羟基-5-硝基吡啶置于氢氧化钾,Tetrafluoroboric Acid,铁粉,溶剂黄146,Sodium Nitrite,三溴氧磷体系中,用喹啉,水,异丙醇,甲苯作为反应溶剂,化学反应 2.33H,反应生成 2-溴-3-碘-5-羟基-吡啶
参考文献:5-Substituted Derivatives Of 6-Halogeno-3-((2-(S)-Azetidinyl)Methoxy)Pyridine And 6-Halogeno-3-((2-(S)-Pyrrolidinyl)Methoxy)Pyridine With Low Picomolar Affinity For α4β2 Nicotinic Acetylcholine Receptor And Wide Range Of Lipophilicity: Potential Probes For Imaging With Positron Emission Tomography
标题:5-Substituted Derivatives Of 6-Halogeno-3-((2-(S)-Azetidinyl)Methoxy)Pyridine And 6-Halogeno-3-((2-(S)-Pyrrolidinyl)Methoxy)Pyridine With Low Picomolar Affinity For α4β2 Nicotinic Acetylcholine Receptor And Wide Range Of Lipophilicity: Potential Probes For Imaging With Positron Emission Tomography
摘要:Potential Positron Emission Tomography (Pet) Ligands With Low Picomolar Affinity At The Nicotinic Acetylcholine Receptor (Nachr) And With Lipophilicity (Log D) Ranging From-1.6 To +1.5 Have Been Synthesized. Most Members Of The Series,Which Are Derivatives Of 5-Substituted-6-Halogeno-A-85380,Exhibited A Higher Binding Affinity At Alpha4Beta2-Nachrs Than Epibatidine. An Analysis,By Molecular Modeling,Revealed An Important Role Of The Orientation Of The Additional Heterocyclic Ring On The Binding Affinity Of The Ligands With Nachrs. The Existing Nicotinic Pharmacophore Models Do Not Accommodate This Finding. Two Compounds Of The Series,6-[f-18]-Fluoro-5-(Pyridin-3-yl)-A-85380 ([f-18]31) And 6-Chloro-3-((2-(S)-Azetidinyl)Methoxy)-5-(2-[f-18]-Fluoropyridin-5-yl)Pyridine) ([f-18]35),Were Radiolabeled With F-18. Comparison Of Pet Data For [f-18]31 And 2-[f-18]Fa Shows The Influence Of Lipophilicity On The Binding Potential. Our Recent Pet Studies With [f-18]35 Demonstrated That Its Binding Potential Values In Rhesus Monkey Brain Were Ca. 2.5 Times Those Of 2-[f-18]Fa. Therefore,[f-18]35 And Several Other Members Of The Series,When Radiolabeled,Will Be Suitable For Quantitative Imaging Of Extrathalamic Nachrs.
DOI:10.1021/jm030432V