CAS: 693-30-1; 2-((2-Chloroethyl)Thio)Ethan-1-Ol

化学文摘社编号693-30-1的化学化合物,被归类为硫芥子,是一种化学战剂,其特点是能够形成与DNA相互作用的烷基剂,从而产生潜在的诱变和致癌效应;该化合物一般表现为无色的黄色液体,有明显的气味;在有机溶剂中溶解,且水溶性有限;由于其活性作用,可造成严重的化学灼伤,并在接触时对呼吸系统造成损害;甲硫芥子在环境中的持久性也是众所周知的,引起人们对其潜在长期影响的关切;在处理该物质时,安全措施至关重要,因为它对健康构成重大风险;其使用受到旨在控制化学武器的各种国际条约的严格管制.

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物理性质

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上下游产品

芥子气 1-Chloro-2-(2-Chloroethylsulfanyl)Ethane 505-60-2
硫二甘醇 2,2'-Thiobis-Ethanol 111-48-8

合成工艺路线路线简述

    📜硫二甘醇置于氯化亚砜,氯仿体系中,化学反应生成 2-羟基乙基 2-氯乙基硫醚
    参考文献:合成2-氯-2'-羟基二乙基硫醚,与半胱氨酸和缬氨酸反应,并在水性介质中测量反应速率.
    标题:合成2-氯-2'-羟基二乙基硫醚,与半胱氨酸和缬氨酸反应,并在水性介质中测量反应速率.
    摘要:
    DOI:10.1021/ja01214A059

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    专利信息


    专利号:US-2009048153-A1
    优先权日:2004-12-03
    标题:Composition for treating sulfur mustard toxicity and methods of using same
    发明人：VARMA SHAMBHU D; PETRALI JOHN
    权利人:UNIV MARYLAND; US GOV SEC ARMY
    摘要:One embodiment of the present invention provides a composition, comprising, in amounts effective to treat sulfur mustard or half sulfur mustard induced toxicity or skin damage: an agent that inhibits alkylation of —SH and >NH protein groups; an agent that reduces —SS— to SH; a scavenger of reactive oxygen species; a substrate that maintains tissue reduction-oxidation status; an agent that protects against invading inflammatory cells and associated oxidative stress; an antagonist of prostaglandin synthesis; and an agent that induces tissue regeneration. Methods of using the composition are also provided.

    专利号:US-10022454-B2
    优先权日:2008-09-23
    标 题 :Functionalized phosphorodiamites for therapeutic oligonucleotide synthesis
    发明人：PETERSEN SCOTT G
    权利人:PETERSEN SCOTT G; LIPOSCIENCES LLC
    摘要:Disclosed herein are compositions and methods for generating ribo-nucleic neutral (RNN) or deoxyribo-nucleic-neutral (DNN) polynucleotides with reduced anionic charge, for improved intracellular delivery. Also disclosed herein are methods of using RNN and DNN compositions.

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    合成参考文献


    摘要:National Technical Information Service., PB158-507
    摘要:Journal of Pharmacology and Experimental Therapeutics., 93(1), 1948
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