CAS: 66722-57-4; 2-((4-((2-Isopropoxyethoxy)Methyl)Phenoxy)Methyl)Oxirane

该化合物是一种合成有机化合物,其特征为复杂的分子结构,包括一个四氧化物功能组.该化合物具有苯氧组,表明存在一种与一种醚结合的苯酚结构,还含有一种乙氧替代成分,有助于其溶解性和再活性.该氧化物环的存在表明它可能参与环形开关反应,使其在各种化学合成中有用.其分子设计意味着在聚合化学等领域的潜在应用,可以作为单体或交叉剂.此外,分支的烷基组(1-甲基乙氧)可能强化其疏水性,影响其在不同溶剂中的行为.

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4-异丙氧基乙氧基甲基酚 4-((2-Isopropoxyethoxy)Methyl)Phenol 177034-57-0

合成工艺路线路线简述

    📜对羟基苯甲醇置于potassium Carbonate体系中,用 乙腈 作为反应溶剂,化学反应 24.0H,反应生成 [[4-[[2-(1-甲基乙氧基)乙氧基]甲基]苯氧基]甲基]环氧乙烷
    参考文献:Kr20220146218A
    标题:Kr20220146218A

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    专利信息


    专利号:WO-2016135616-A1
    优先权日:2015-02-27
    标题:An improved process for the preparation of bisoprolol and its intermediate
    发明人：MORTHALA RAGHAVENDAR RAO; GHARPURE MILIND; JAGTAP ASHUTOSH; MHASKAR MAHESH; KRISHNMURTHY DHILEEPKUMAR
    权利人:PIRAMAL ENTPR LTD
    摘要:The present invention provides an improved process for the preparation of 4-((2-isopropoxy ethoxy) methyl) phenol compound (I), used as an intermediate in many organic synthesis; particularly a key intermediate for the synthesis of l-[4[2(l-methylethoxy) ethoxy methyl] phenoxy]-3-(l-methylethylamino)-propan-2-ol; commonly known as Bisoprolol or its pharmaceutically acceptable salts. The process comprises reacting the 4-hydroxybenzyl alcohol (II) with the 2-isopropoxyethanol (III) in the presence of activated silica and optionally, in the presence of solvent.

    专利号:US-6087512-A
    优先权日:1996-09-18
    标题:Process for preparation of glycidyl ether
    发明人：FURUKAWA YOSHIRO; KITAORI KAZUHIRO; YANAGIMOTO TETSUYA; MIKAMI MASAFUMI; YOSHIMOTO HIROSHI; OTERA JUNZO
    权利人:DAISO CO LTD
    摘要:A process for preparation of a glycidyl ether which is characrelized in reacting an epoxy compound of the formula ##STR1## wherein X is halogen or sulfonyloxy in the presence of a fluoride salt, with an alcohol. According to the above method, glycigyl ethers or their optically active compounds important as intermediates for synthesis of medicines are easily obtained in good yield and especially the optically active compounds are obtained with highly optical purity.

    专利号:US-2021154202-A1
    优先权日:2018-04-17
    标 题:Synthesis of dentimol, an antiglaucoma drug
    发明人：LANCINA MICHAEL; WANG JUAN; YANG HU
    权利人:UNIV VIRGINIA COMMONWEALTH
    摘要:Compounds, comprising a selective β-blocker coupled to a PAMAM dendrimer via a flexible spacer, and compositions containing the compounds, are provided. Methods of making and using the compounds and compositions for the treatment of glaucoma and other maladies are also provided.

    专利号:WO-2007069266-A3
    优先权日:2005-12-12
    标题 :A novel process for the synthesis of bisodprolol and its intermediate
    发明人：RAMAKRISHNAN ARUL; AJAY DAYALJI CHAUHAN; RAJESH HARSHNATH PATHAK; RUCHI AGARWAL
    权利人:UNICHEM LAB LTD; RAMAKRISHNAN ARUL; AJAY DAYALJI CHAUHAN; RAJESH HARSHNATH PATHAK; RUCHI AGARWAL
    摘要:This invention relates to a manufacturing process for the preparation of bisoprolol and its pharmaceutically acceptable salt as well as its intermediates. The intermediate 4-[(2-isopropoxyethoxy)methyl]phenol is prepared by reaction of 4-hydroxybenzyl alcohol with 2-isopropoxy ethanol in presence of Amberlyst 15 in high yield with high purity.

    专利号:WO-2007069266-A2
    优先权日:2005-12-12
    标 题 :A novel process for the synthesis of bisodprolol and its intermediate

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    合成参考文献


    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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