CAS: 57147-25-8; 3,4-Dihydropyridin-2(1H)-One

上下游产品

CAS号28446-58-4 3-BUTENAMIDE | CAS号201230-82-2 carbon monoxide | CAS号39662-64-1 6-ethoxypiperid... | CAS号39871-47-1 2-azid°Cyclopen... | CAS号1121-89-7 戊二酰亚胺 | CAS号6089-09-4 4-戊炔酸 | CAS号64-19-7 冰醋酸 | CAS号108046-33-9 1-苄基-3,4-二氢-1H-...

📜6-乙氧基哌啶-2-酮置于吡啶,4-甲基苯磺酸吡啶体系中,用 甲苯 作为反应溶剂,化学反应 8.0H,以456 Mg的收率获得产物3,4-二氢-2(1H)-吡啶酮
参考文献:The Synthesis Of Indoline And Benzofuran Scaffolds Using A Suzuki-miyaura Coupling/oxidative Cyclization Strategy
标题:The Synthesis Of Indoline And Benzofuran Scaffolds Using A Suzuki-miyaura Coupling/oxidative Cyclization Strategy
摘要:The Generation Of Indolines And Benzofurans From The Combination Of Suzuki-Miyaura Coupling Reactions With Oxidative Cyclizations Is Described.
DOI:10.1021/ol401974V

专利信息

专利号:US-12331021-B2
优先权日:2020-09-10
标题 :Total synthesis of pirfenidone
发明人：ZHOU LIHUA
权利人:SUZHOU FUDE ZHAOFENG BIOCHEMICAL TECH CO LTD
摘要:The present invention relates to a process for the synthesis of Pirfenidone (1) from 5-Methyl-3,4-dihydro-2-pyridone and halobenzene (chlorobenzene, bromobenzene, or iodobenzene) in the presence of a catalytic system consisting of a copper salt and an organic ligand, in the presence of a base.

专利号:US-4658031-A
优先权日:1982-10-07
标 题:Synthesis of 2-substituted-5-methyl-pyridines and intermediates therefor
发明人：HARTMANN LUDWIG A; STEPHEN JOHN F
权利人:ICI AMERICA INC
摘要:A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicies as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.

专利号:US-4584380-A
优先权日:1982-10-07
标 题:Synthesis of 2-substituted-5-methyl-pyridines and intermediates therefor
发明人：HARTMANN LUDWIG A; STEPHEN JOHN F
权利人:ICI AMERICA INC
摘要:A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicides as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.

专利号:US-4473696-A
优先权日:1982-10-07
标题:Synthesis of 2-substituted-5-methyl-pyridines
发明人：HARTMANN LUDWIG A; STEPHEN JOHN F
权利人:ICI AMERICA INC
摘要:A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicides as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.

专利号:US-6362009-B1
优先权日:1997-11-21
标 题 :Solid phase synthesis of heterocycles
发明人：MUNOZ BENITO; CHEN CHIXU
权利人:MERCK & CO INC
摘要:Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrahydropyridines and tetrahydropyridines compounds and libraries containing such compounds are provided. Methods for screening the libraries and compounds and pharmaceutical compositions containing compounds prepared by the methods are provided.

专利号:US-6841559-B1
优先权日:1999-11-19
标 题:Pyridinones to treat and prevent bacterial infections
发明人：ALMQVIST FREDERIC; EMTENAS HANS; HULTGREN SCOTT J; PINKNER JEROME S
权利人:WASHINGTON UNIVERSITY OF ST LO
摘要:Novel pyridinones and their derivatives which are effective in treating or preventing Gram-negative bacterial infections are provided. The pyridinones are stable and easily derivatized; the methods by which these derivatizations occur is described. Two regioselective and functional group tolerant methods for the synthesis of the novel pyridinones are also provided. One such synthetic method involves reacting an imine and a Meldrum's acid derivative in solution. The other synthetic method is a solid phase synthesis of the pyridinones in which an imine is prepared bound to a solid support and a Meldrum's acid derivative is reacted with the imine. Novel imine intermediates useful in the solid phase and solution methods of synthesizing the pyridionones are also described.