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CAS号1193-24-4 4,6-二羟基嘧啶 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号14256-99-6 4, 6-二羟基-5-甲酰基嘧啶 | CAS号1193-21-1 4,6-二氯嘧啶 | CAS号54503-93-4 4-氯-6-哌啶-5-嘧啶甲醛 | CAS号14160-94-2 4-氯-6-(甲基氨基)-5-嘧啶甲醛 | CAS号23000-47-7 4-氯-1-(对甲苯)-1H-... | CAS号5399-92-8 4-氯-1H-吡唑并[3,4-d]嘧啶 | CAS号60025-09-4 4-氨基-6-氯嘧啶-5-甲腈 | CAS号54503-94-5 4-氯-6-吗啉-5-嘧啶甲醛 | CAS号5305-45-3 4,6-二氯嘧啶-5-甲腈 | CAS号14160-93-1 4-氨基-6-氯-5-醛基嘧啶 | CAS号23000-43-3 1-甲基-4-氯吡唑并[3,4-d]嘧啶 | CAS号64705-52-8 Boronic acid,(5...合成工艺路线路线简述
- 合成目标产物 4,6-Dichloro-5-Pyrimidinecarbaldehyde 主要起始原料 4,6-Dihydroxypyrimidine
- (文献来源)合成步骤主要原料 4,6-Dihydroxypyrimidine
4,6-二羟基嘧啶置于三氯氧磷体系中,化学反应生成 4,6-二氯-5-嘧啶甲醛
参考文献:Process And Intermediates For Preparing A Jak1 Inhibitor
标题:Process And Intermediates For Preparing A Jak1 Inhibitor
摘要:本发明涉及制备伊他西替尼或其盐的工艺,以及与之相关的合成中间体.
专利信息
专利号:WO-2014074883-A1
优先权日:2012-11-08
标题 :Novel synthesis of ld101
发明人:THOMPSON ANDREW S; CHENG HUA
权利人:LYNDOR BIOSCIENCES L L C
摘要:Novel synthetic methods for preparation of LD101, a compound according to formula (A) are disclosed.
专利号:CN-102731375-A
优先权日:2012-06-20
标 题:Synthesis of 4,6-dichloro-5-pyrimidinecarbaldehyde
专利号:EP-4086245-A1
优先权日:2018-01-30
标 题 :Processes for preparing intermediates for the synthesis of a jak inhibitor
专利号:US-7579356-B2
优先权日:2005-05-04
标 题:Thia-tetraazaacenaphthylene kinase inhibitors
发明人:BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; PANDEY NIRANJAN B; POWELL MARK T
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.
专利号:US-2008108611-A1
优先权日:2006-01-19
标 题 :Substituted thienopyrimidine kinase inhibitors
发明人:BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; EMANUEL STUART L; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; MIDDLETON STEVEN A; PANDEY NIRANJAN B; POWELL MARK T
权利人:BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; EMANUEL STUART L; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; MIDDLETON STEVEN A; PANDEY NIRANJAN B; POWELL MARK T
摘要:The present invention is directed to thienopyrimidine compounds of formula (I): n n n n n n n n n n and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
专利号:US-2009111810-A1
优先权日:2007-10-23
标题:Substituted pyrimidine-5-carboxamide and 5-carboxylic ester kinase inhibitors
发明人:CONNOLLY PETER J; HUGHES TERRY V; WETTER STEVEN K
权利人:CONNOLLY PETER J; HUGHES TERRY V; WETTER STEVEN K
摘要:The present invention is directed to substituted pyrimidine-5-carboxamide and 5-carboxylic ester compounds of Formula (I): n n n n n n n n n n and forms thereof wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and L are as defined herein and their synthesis and use as kinase inhibitors for treating a chronic or acute protein kinase mediated disease.