CAS: 53-05-4; Tetrahydro Cortisone

上下游产品

CAS号1482-51-5 5-Alpha-二氢可的松

📜可的松 反应生成 四氢可的松
参考文献:真菌alternaria Bataticola对delta 4-3-酮孕烯化合物的微生物还原作用.
标题:真菌alternaria Bataticola对delta 4-3-酮孕烯化合物的微生物还原作用.
摘要:
DOI:10.1016/0003-9861(59)90473-4

专利信息

专利号:US-5762918-A
优先权日:1992-03-23
标题:Methods of using steroid-polyanionic polymer-based conjugated targeted to vascular endothelial cells
发明人：THORPE PHILIP E
权利人:UNIV TEXAS
摘要:This invention discloses new targeted conjugates for the delivery of a compound, and particularly, a steroid, to vascular endothelial cells. The conjugates comprise two components, preferably linked by a selectively-hydrolyzable bond, such as an acid-labile bond or enzyme-sensitive bond. The first component, a polyanionic polymer, and preferably, a polysulphated polymer such as a heparin-derivative, specifically directs the conjugate to vascular endothelial cells. The second component is a selected agent, such as a steroid, which exerts a specific effect on the target cell following its release. In particular, the present invention provides novel conjugated angiogenesis inhibitors, for use in the treatment of pathogenic conditions including cancer, arthritis, and diabetic blindness. An inhibitor comprising a heparin derivative and the anti-angiogenic steroid, cortisol, is herein shown to be markedly acid-labile, to suppress DNA synthesis and cell migration in human umbilical vein endothelial cells, to retard or abolish (depending pending on the route of injection) the vascularization of sponges in vivo and to retard lung tumor growth in mice by 65%. No adverse effects of the conjugate were detected, and equivalent treatments with a mixture of heparin plus cortisol were significantly less effective in all cases.