CAS: 51336-97-1; 2-Chloro-1-(3,4-Difluorophenyl)Ethanol

上下游产品

2-chloro-1-(3,4-difluorophenyl)ethan-1-one ortho-difluorobenzene -2-aethylaminoaethanol1-3.4-Difluorphenyl-2-aethylaminoaethanol 2-amino-1-(3,4-difluoro-phenyl)-ethanol (+/-)-3,4-difluoroisoproterenol 2-(butylamino)-1-(3,4-difluorophenyl)ethan-1-ol

📜1,2-二氟苯置于sodium Tetrahydroborate,三氯化铝体系中,用 甲醇,二硫化碳 作为反应溶剂,化学反应生成 2-氯-1-(3,4-二氟苯基)乙醇
参考文献:Bercher; Ehlers; Grisk,Pharmazie,1976,Vol. 31,# 6,P. 351-354
标题:Bercher; Ehlers; Grisk,Pharmazie,1976,Vol. 31,# 6,P. 351-354

专利信息

专利号:EP-2644590-A1
优先权日:2012-03-30
标 题:Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:US-2018148745-A1
优先权日:2015-05-26
标题:Hemoprotein catalysts for improved enantioselective enzymatic synthesis of ticagrelor
发明人：ARNOLD FRANCIS H; RENATA HANS; MCINTOSH JOHN A; LEWIS RUSSELL D; KAN SEK BIK JENNIFER; HERNANDEZ KARI; COELHO PEDRO; ROZZELL DAVID; ZHANG CHEN
权利人:CALIFORNIA INST OF TECHN; PROVIVI INC
摘要:The present invention provides methods by which trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine and related cyclopropane compounds are prepared using synthetic strategies that include a biocatalytic cyclopropanation step.

专利号:CN-111763662-A
优先权日:2019-11-29
标题 :Ketoreductase and its application in the synthesis of ticagrelor intermediates

专利号:CN-111763662-B
优先权日:2019-11-29
标题 :Ketoreductase and its application in the synthesis of ticagrelor intermediates

专利号:EP-2628721-A1
优先权日:2012-02-20
标题 :Synthesis of 2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

专利号:WO-2013144295-A1
优先权日:2012-03-30
标题 :Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts