专利号:US-12365930-B2 优先权日:2016-07-14 标题:Method for rapid in vitro synthesis of glycoproteins via recombinant production of N-glycosylated proteins in prokaryotic cell lysates 发明人:JEWETT MICHAEL CHRISTOPHER; STARK JESSICA CAROL; DELISA MATTHEW P; JAROENTOMEECHAI THAPAKORN 权利人:UNIV NORTHWESTERN; UNIV CORNELL 摘要:Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.
专利号:US-11912654-B2 优先权日:2021-09-03 标 题:Process for stereospecific synthesis of vitamin K2 and its novel intermediates 发明人:MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; SHAH ASHWIN; VORA PARIN; MAHALE UMAKANT 权利人:SYNERGIA LIFE SCIENCES PVT LTD 摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7. The present disclosure further discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.
专利号:WO-2023031841-A1 优先权日:2021-09-03 标题:A process for the stereospecific synthesis of vitamin k2 and its intermediates 发明人:MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; VORA PARIN; MAHALE UMAKANT 权利人:SYNERGIA LIFE SCIENCES PVT LTD 摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7, in particular. It also discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.
专利号:US-4451565-A 优先权日:1981-03-10 标 题:Enzyme-mediated synthesis of esters and lactones 发明人:GATFIELD IAN; SAND THEODOR 权利人:HAARMANN & REIMER GMBH 摘要:In the enzyme-mediated synthesis of an ester or lactone from at least one carboxylic acid of the formula R-CH2-CH2-COOH wherein R is a hydrogen atom, or a hydrocarbon radical which has 1 to 21 carbon atoms and which can be optionally substituted by hydroxyl groups or alkoxy groups with 1 to 10 carbon atoms, with at least one primary or secondary alcohol having 1 to 15 carbon atoms, the improvement which comprises employing as the enzyme the esterase from Mucor miehei and effecting the synthesis in the absence of water. Advantageously, the synthesis is effected at about room temperature, the mol ratio of carboxylic acid to alcohol is from about 1:1 to 1:1.1, and the enzyme is used in a quantity of about 3 to 20% by weight of the carboxylic acid. The absence of water facilitates recovery, as by distillation.
专利号:US-8822187-B1 优先权日:2011-04-27 标题:Polypeptides, nucleic acid molecules, and methods for synthesis of triterpenes 发明人:CHAPPELL JOE; NIEHAUS THOMAS D; OKADA SHIGERU; DEVARENNE TIMOTHY P; WATT DAVID S 权利人:CHAPPELL JOE; NIEHAUS THOMAS D; OKADA SHIGERU; DEVARENNE TIMOTHY P; WATT DAVID S; UNIV KENTUCKY RES FOUND 摘要:This application relates to the polypeptides, nucleic acid molecules, vectors, transfected cells, and methods for synthesis of triterpenes, including botryococcene.
专利号:US-3674818-A 优先权日:1969-12-05 标 题:Synthesis of a material with juvenile hormone activity 发明人:LAW JOHN H 权利人:US HEALTH EDUCATION & WELFARE 摘要:Synthesis of a material with juvenile hormone activity by reacting crude or purified farnesoic acid with alcoholic hydrogen chloride wherein the alcohol is selected from the group consisting of ethanol, methanol, n-propanol and n-pentanol. Various comparisons are shown with other related compounds and an exemplary list of insects sensitive to the material is set forth.
1: Kashi M, Varseh M, Hariri Y, Chegini Z, Shariati A. Natural compounds: new therapeutic approach for inhibition of Streptococcus mutans and dental caries. Front Pharmacol. 2025 Apr 1;16:1548117. doi: 10.3389/fphar.2025.1548117. 2: Iriarte-Mesa C, Bergen J, Danielyan K, Crudo F, Marko D, Kählig H, Del Favero G, Kleitz F. Functionalization of Silica Nanoparticles for Tailored Interactions with Intestinal Cells and Chemical Modulation of Paracellular Permeability. Small Sci. 2024 Aug 1;5(1):2400112. doi: 10.1002/smsc.202400112. 3: Futamura Y, Yamamoto K, Uson-Lopez R, Aono H, Shimizu T, Hori Y, Kino K, Osada H. Inhibitory effect of copper chelators on the budding in Candida albicans. Antimicrob Agents Chemother. 2025 Apr
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