CAS: 34911-51-8; Bupropion Impurity 13

上下游产品

CAS号34841-35-5 间氯苯丙酮 | CAS号17408-16-1 3-硝基苯丙酮 | CAS号93-55-0 苯丙酮 | CAS号1197-05-3 1-(3-氨基苯基)丙-1-酮 | CAS号34841-39-9 安非他酮 | CAS号92264-81-8 羟基安非他酮 | CAS号357399-43-0 羟基1-(3-氯苯基)-2-[...

3'-氯丙酮苯置于溴体系中,用 乙醚 用作溶剂,化学反应生成2-溴-3'-氯苯丙酮
参考文献:分子内苯偶姻反应立体发散合成色曼酮和黄酮
标题:分子内苯偶姻反应立体发散合成色曼酮和黄酮
摘要:外消旋混合物的立体发散反应策略(立体发散的rrm)是首次在分子内安息香反应中采用,并导致色酮/黄酮与两个连续的立体中心快速接触.一步即可获得具有中等至优异对映选择性的产品易分离的立体异构体.邻苯二酚型添加剂被证明对实现所需的非对映选择性和对映选择性至关重要.
Doi:10.1021/acs.Orglett.6B01767

专利信息

专利号:US-7737302-B2
优先权日:2007-07-06
标 题:Process for preparing bupropion hydrochloride
发明人：WU CHAOGANG; XIANG HUAYOU; YU XIANGHUA; HE CHUN; LI FENGYING; SHI XIANGHONG; LU CHENGYUE; CHEN GUOLIANG; GE YANGXIANG
权利人:ZHEJIANG APELOA MEDICAL TECHNO
摘要:This invention described a synthesis method of bupropion hydrochloride. m-chloropropiophenone was brominated directly with bromine, then aminated with t-butylamine and finally reacted with HCl to obtain crude product of bupropion hydrochloride. Pure product was obtained after recrystallization. This method is convenient and suitable for commercial manufacturing because of low cost of production, high yield, less byproducts and being environmental friendly.

专利号:CA-2400482-C
优先权日:2000-02-22
标题 :Bupropion metabolites and methods of their synthesis and use

专利号:AU-2005247034-A1
优先权日:2000-02-22
标题:Bupropion metabolites and methods of their synthesis and use

专利号:AU-2005247034-B2
优先权日:2000-02-22
标题 :Bupropion metabolites and methods of their synthesis and use

专利号:EP-1602369-A2
优先权日:2000-02-22
标题 :Bupropion Metabolites and Methods of their Synthesis and Use

专利号:US-2006058300-A1
优先权日:1999-03-01
标 题 :Intermediates of bupropion metabolites synthesis