CAS: 342385-52-8; (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-Oxohexanoic Acid Xhydrate

专利信息

专利号:US-7655769-B2
优先权日:2004-07-20
标题:Orthogonally protected disaccharide building blocks for synthesis of heparin
发明人：HUNG SHANG-CHENG; LEE JING-CHYI; LU XIN-AN
权利人:ACADEMIA SINICA
摘要:Orthogonally protected disaccharide building blocks for synthesis of heparin saccharide are disclosed. The disaccharide building block has a formula (I), in which L is a leaving group, P 1 , P 2 , P 3 and P 4 are different, and of them P 1 is an ester-type protecting group, P 2 is a hydroxyl protecting group that could be oxidized to a carboxylic acid, P 3 is a hydroxyl protecting group, and P 4 is a hydroxyl protecting group which allows chemoselective deprotection with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). Acting as an elongation unit, the disaccharide building block of formula (I) may react with a starting unit of formula (II) to synthesize a heparin saccharide of desired size.

专利号:WO-2009033269-A1
优先权日:2007-09-11
标 题 :Novel polysaccharide immunogens from alloiococcus otitidis and synthesis of a glycoconjugate vaccine thereof
发明人：MONTEIRO MARIO ARTUR; ARAR SARIF; HARIMAYA ATSUSHI
权利人:UNIV GUELPH; MONTEIRO MARIO ARTUR; ARAR SARIF; HARIMAYA ATSUSHI
摘要:The application relates to Alloiococcus otitidis cell surface polysaccharides, compositions comprising Alloiococcus otitidis cell surface polysaccharides, synthesis of a glycoconjugate vaccine and includes kits, methods and uses thereof.

专利号:US-8273887-B2
优先权日:2008-09-30
标题:Processes for synthesis of opiate alkaloid derivatives
发明人：MANNINO ANTHONY; ZDRODOWSKI JAMES
权利人:MANNINO ANTHONY; ZDRODOWSKI JAMES; MALLINCKRODT LLC
摘要:The present invention provides processes for the synthesis of opiate alkaloids. In particular, the opiate alkaloids produced by the process of the invention are typically intermediate compounds that may be utilized to produce a variety of biologically active alkaloids including buprenorphine and diprenorphine.

专利号:US-4818816-A
优先权日:1981-04-28
标 题:Process for the organic synthesis of oligosaccharides and derivatives thereof
发明人：PETITOU MAURICE; JACQUINET JEAN-CLAUDE; SINAY PIERRE; CHOAY JEAN; LORMEAU JEAN-CLAUDE; NASSR MAHMOUD
权利人:CHOAY SA
摘要:The invention relates to a process for the organic synthesis of oligosaccharides constituting or comprising fragments of acid mucopolysaccharides comprising the reaction of two compounds constituted or terminated by units of glucosamine structure and of uronic acid structure respectively, said units being specifically substituted. This process particularly enables valuable anticoagulant drugs to be obtained.

专利号:US-4943630-A
优先权日:1982-10-27
标题 :Method for carrying out the organic synthesis of oligosaccharides containing galactosamine-uronic acid patterns, new oligosaccharides obtained and biological applications thereof
发明人：JACQUINET JEAN-CLAUDE; PETITOU MAURICE; SINAY PIERRE; CHOAY JEAN
权利人:CHOAY SA
摘要:Process for the organic synthesis of oligosaccharides forming or corresponding to fragments of acid mucopolysaccharides wherein two compounds comprised of or terminated respectively by patterns of galactosamine structure and patterns of uronic acid structure. Said patterns are specifically substituted. Said process results in oligosaccharides usable particularly in therapy.

专利号:US-7732414-B2
优先权日:2000-12-22
标题 :C-glycoside compounds for stimulating the synthesis of glycosaminoglycans
发明人：DALKO MARIA; BRETON LIONEL
权利人:OREAL
摘要:C-glycoside compounds are suited for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and/or proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and/or keratinocytes.