CAS: 338454-14-1; 1H-Indazole-5-Boronic Acid

上下游产品

CAS号53857-57-1 5-溴吲唑

📜5-溴吲唑置于正丁基锂,硼酸三甲酯,盐酸,水体系中,用 乙醚,正己烷 用作溶剂,化学反应 18.0H,以19%的收率获得1H-吲唑-5-硼酸
参考文献:Substituted 5-Benzyl-2,4-Diaminopyrimidines
标题:Substituted 5-Benzyl-2,4-Diaminopyrimidines
摘要:该发明涉及通式(a)中的取代5-苄基-2,4-二氨基嘧啶,其中r1为c2-C3烷基,R2为杂环烷基,苯基或萘基,由其中一个c原子连接,R3为c2-C6烷基,烯基,环烷基,环烷基烷基,杂环烷基烷基,烷基磺酰基,环烷基磺酰基,环烷基烷基磺酰胺基,杂环烷基磺酰基,杂环烷基烷基磺酰基或二烷基磺酰胺基;其中烷基,环烷基和烯基可以单独或组合带有最多6个碳原子,可以带有最多6个环成员杂环地,单独或组合,且基团r2和r3可以被取代;以及化合物的酸盐.该发明还涉及一种制备上述5-苄基-2,4-二氨基嘧啶的方法,中间体产物,相应药物以及将5-苄基-2,4-二氨基嘧啶用作药物制剂的用途.这些产品具有抗生素特性,可用于对抗或预防传染病.

专利信息

专利号:US-8378104-B2
优先权日:2010-02-11
标 题 :7-aminofuropyridine derivatives
发明人：HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
权利人:OSI PHARMACEUTICALS LLC; HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
摘要:Compounds of Formula 1, as shown below and defined herein: n n n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.