CAS: 3282-56-2; 1-(Tert-Butyl)-4-Nitrobenzene

上下游产品

tert-butylbenzene 1,4-di-tert-butylbenzene methyl nitrate 1,1-bis(4-t-butylphenyl)methane 4-tert-Butylaniline 2-bromo-1-tert-butyl-4-nitrobenzene 1-(tert-butyl)-2-chloro-4-nitrobenzene 1-tert-butyl-2,4-dinitrobenzene

📜4-叔丁基苯胺置于双氧水,Potassium Carbonate体系中,用 水,乙腈 用作溶剂,以90%的收率获得1-特-丁基-4-硝基苯
参考文献:碱促进的过氧化物体系,可有效合成硝基芳烃和苯甲酰胺
标题:碱促进的过氧化物体系,可有效合成硝基芳烃和苯甲酰胺
摘要:已经开发出一种有用且有效的方法,该方法使用过氧化物和碱从几种芳族胺(包括杂环)合成硝基芳烃.该氧化反应非常容易处理,并以高收率提供了产物.用这种无金属的催化体系也成功地从苄胺形成了苯甲酰胺,收率非常好.
Doi:10.1016/j.Tetlet.2019.151076

专利信息

专利号:US-11773118-B2
优先权日:2019-02-21
标 题:Methods of making high enantioselective secondary alcohols
发明人：YU CHENG-DER TONY; HSIEH YIH-HUANG; LIN SHU-YI; CHAO CHIN-SHENG; HSIEH YIN-CHENG; LAI MING-TAIN
权利人:OBI PHARMA INC
摘要:A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The “R-formâ€? compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at later stage. The stereo chemistry is established by 5 steps chemo-enzyme combination synthesis to afford 99% optical purity. After then, the “S-formâ€? compound OBI-3424 is prepared with improving overall yield of 54% from compound OBI-3424-5. The stereo chemistry is established by 4 steps combination of chemo-enzyme synthesis with excellent optical purity of 99%.

专利号:US-7968734-B2
优先权日:2004-07-01
标 题 :Organocatalysts and methods of use in chemical synthesis
发明人：WANG WEI; WANG JIAN; LI HAO
权利人:STC UNM
摘要:The present invention pertains generally to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use.

专利号:US-10458995-B2
优先权日:2016-03-25
标 题 :Combinatorial synthesis and biomarker development
发明人：MOOLA MURALIDHAR REDDY
权利人:MOOLA MURALIDHAR REDDY
摘要:Provided herein are methods, kits, and compositions for use in the diagnosis and treatment of diseases. Peptoids recognized by Alzheimers disease specific antibodies are identified.

专利号:US-9505799-B2
优先权日:2011-05-13
标题:18F-labeled precursor of PET radioactive medical supplies, and preparation method thereof
发明人：CHI DAE-YOON; LEE BYOUNG-SE; PARK CHANSOO; LEE MIN-HYUNG; CHA HYOJIN; CHO WOOJIN; KANG HEEWON; KIM KYUNGHUN
权利人:CHI DAE-YOON; LEE BYOUNG-SE; PARK CHANSOO; LEE MIN-HYUNG; CHA HYOJIN; CHO WOOJIN; KANG HEEWON; KIM KYUNGHUN; FUTURECHEM CO LTD
摘要:The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing 18 F using the same through a single step. The precursor having a tetravalent organic salt leaving group of the present invention can simplify the known complex multistep preparation of radioactive medical supplies into a single step, can save production costs because an excessive amount of a phase transfer catalyst is not required, facilitates separation of a compound after reaction, and enables rapid reaction velocity. The features are appropriate for the mass production of PET radioactive medical supplies by an automated synthesis system.

专利号:US-11739062-B2
优先权日:2017-08-18
标题:Methods for 1,4-diazo N-heterocycle synthesis
发明人：DAI MINGJI; Ye Zhishi
权利人:PURDUE RESEARCH FOUNDATION
摘要:The present disclosure relates to novel synthetic method of making 1, 4-diazo N-heterocycles via intermolecular amphoteric diamination of allenes, and to the compounds made by the novel synthetic method.

专利号:US-8466157-B2
优先权日:2009-03-06
标题:Proteasome inhibitors having chymotrypsin-like activity
发明人：LAWRENCE HARSHANI; GE YIYU; SEBTI SAID M; GUIDA WAYNE
权利人:LAWRENCE HARSHANI; GE YIYU; SEBTI SAID M; GUIDA WAYNE; UNIV SOUTH FLORIDA; H LEE MOFFITT CANCER CT & RES
摘要:Disclosed herein is the use of HLM-008182, as well as its analogues formed via in-house synthesis, as a potent proteasome inhibitors. A new method was developed for HLM-008182 through a four-step protocol and the method was further optimized to a two step protocol. The synthesis in both protocols was regioselective with TiCl 4 . The reaction was highly efficient with microwave assisted heating and THF as solvent. The modification around the molecule HLM-008182 established primary SAR, indicating that the proteasome inhibition activity was a function of the 2-side chain.