CAS: 2812-32-0; (S)-2-(Dimethylamino)-3-Methylbutanoic Acid

相似化合物

103478-58-6 42417-65-2 45170-31-8

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CAS号50-00-0 甲醛 | CAS号72-18-4 l-缬氨酸 | CAS号67-56-1 甲醇 | CAS号186581-53-3 重氮甲烷 | CAS号2480-23-1 N-甲基-L-缬氨酸

Lyngbyabellin N置于臭氧,盐酸,水体系中,用 二氯甲烷 用作溶剂,化学反应 0.25H,反应生成N,N-二甲基-L-缬氨酸
参考文献:来自海洋蓝细菌的两个扇叶树环礁收藏品的lyngbyabellins Kn
标题:来自海洋蓝细菌的两个扇叶树环礁收藏品的lyngbyabellins Kn
摘要:从中央太平洋帕尔米拉环礁的两个丝状海洋蓝细菌的提取物中分离出五个lyngbyabellin结构类别的脂肽,四个环状(1-3和5)和一个线性(4).通过结合光谱和色谱分析以及碎片的化学合成,阐明了它们的平面结构和绝对构型.除了lyngbyabellins典型的结构特征(例如两个噻唑环和氯化的2-甲基辛酸酯残基)外,这些新化合物还具有几个独特的方面.值得注意的是,代谢物2和3在3-酰氧基-2-甲基辛酸残基上具有罕见的单氯化作用,而lyngbyabellin N(5)具有不寻常的n,N-二甲基缬氨酸末端.Lyngbyabellin N也拥有亮氨酸他汀类药物残基,
Doi:10.1002/ejoc.201200691

专利信息

专利号:US-2024287126-A1
优先权日:2021-05-14
标 题:Novel synthesis of cholesterol
发明人：SCHINZER DIETER; SPIESS OLIVER; MUNT MAXIM; INDOLESE ADRIANO; ROUX LIONEL
权利人:CORDENPHARMA INT GMBH; UNIV OTTO VON GUERICKE MAGDEBURG; CORDENPHARMA INT
摘要:The invention relates to a synthesis of cholesterol; a ring opening step of the compound of formula (I) and subsequent activation and reduction step yielding cholesterol. The inventions relates also to intermediates achieved during said synthesis.

专利号:US-5554725-A
优先权日:1994-09-14
标题:Synthesis of dolastatin 15
发明人：PETTIT GEORGE R
权利人:UNIV ARIZONA
摘要:The present invention relates to the synthesis of natural (-)- dolastatin and the elucidation of the absolute configuration of this important sea hare constituent. A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian Ocean sea hare) depsipeptide dolastatin 15. Reaction of protected (S)-Hiva-(S)-Phe (2c) with isopropenyl chloroformate followed by Meldrum's ester, cyclization (2c→3a) of the product in toluene and finally methylation afforded the key (S)-dolapyrrolidine (Dpy) derivative (3b). Condensation of tripeptide (8) with the three unit Dpy segment (5b) followed by deprotection and coupling (diethyl phosphorocyanidate) led to dolastatin 15 in 11% overall yield. The powerful and selective activity of dolastatin 15 against the U.S. National Cancer Institute's panel of human cell lines is reported.

专利号:US-4978744-A
优先权日:1989-01-27
标题:Synthesis of dolastatin 10
发明人：PETTIT GEORGE R; SINGH SHEO B
权利人:UNIV ARIZONA
摘要:A complicated but extremely important scheme of synthesis has been developed for synthesizing, dolaisoleuine, dolaproine, dolaphenine and dolavaline from readily available starting materials such as Z-(S,S)isoleucine, S-phenylalaline, S-phenylalaninol, S-prolinol, S-mandelate, and S-valine. The requisite amino acids have been combined using several peptide coupling procedures to create pharmaceutically pure dolastatin 10.

专利号:US-6248865-B1
优先权日:1994-05-06
标 题:Compounds useful for the synthesis of dolastatin analogs
发明人：AMBERG WILHELM; BERNARD HARALD; BUSCHMANN ERNST; HAUPT ANDREAS; JANITSCHKE LOTHAR; JANSSEN BERND; KARL ULRICH; KLING ANDREAS; MUELLER STEFAN; DE POTZOLLI BERND; RITTER KURT; THYES MARCO; ZIERKE THOMAS
权利人:BASF AG
摘要:Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.

专利号:AU-2022273995-A1
优先权日:2021-05-14
标题:Novel synthesis of cholesterol

专利号:US-9669015-B2
优先权日:2005-04-07
标题 :Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors
发明人：ZHANG HESHENG
权利人:TIANJIN HEMAY BIO-TECH CO LTD
摘要:This invention is directed to derivatives of piperidine-2,6-dione, or their organic or inorganic salts thereof, a methods of synthesis of these derivatives, and their application as active pharmaceutical ingredient as inhibitors of TNFα releasing in cells, the derivative of piperidine-2,6-dione being of the general formula (I): n nwherein n represents 1, 2, 3, 4, 5 or 6; R 1 represents from one to four of the same or different substituents selected from F, Cl, Br, C 1-4 alkyl, OH, OC 1-4 alkyl, NO 2 , NHC(O)C 1-4 alkyl, NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 ; R 2 represents OR 3 , NR 3 R 4 , N(R 3 )COR 4 , O 2 CR 5 ; R 3 and R 4 represent independently and at each occurrence H or C 1-4 alkyl; R 5 represents CHR 6 NR 7 R 8 , CHR 6 NR 9 C(O)CHR 10 NR 7 R 8 , a heterocycle W or CHR 6 NR 9 C(O)W; R 6 , R 9 , R 10 represent independently and at each occurrence H, or C 1-4 alkyl; R 7 and R 8 represent independently and at each occurrence H, C 1-4 alkyl, or R 7 and R 8 taken together represent 1,3-propylene, 1,4-butylene, 1,5-pentylene, or 1,6-hexylene; W represents four-membered, five-membered, six-membered, seven-membered, or eight-membered saturated or unsaturated heterocycle.