CAS: 27127-79-3; 4-((3S,5R,8R,9S,10S,13R,14S,17R)-14-Hydroxy-3-(((2R,3S,4S,5S,6S)-3-Hydroxy-4-Methoxy-6-Methyl-5-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)-10,13-Dimethylhexadecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Furan-2(5H)-One
该化合物是来自Thevetia genus 植物的心脏球形,主要是Petetia peruviana, 它通过抑制 Na+/ K+-ATPase 泵, 导致细胞内钙浓度增加, 心肌萎缩性增强, 导致细胞内钙浓度增加, 心肌萎缩性增强. 硫丁 B 在结构上类似于像 digoxin 那样的其他玻璃球形, 但由于它独特的糖味, 它可能提供独特的药理动因特性. 它的行动机制使得它与心血管生理学和药理学研究相关. 但是, 它与其他心脏液态表面一样, 它具有狭窄的治疗指数, 需要谨慎的剂量优化. Thevetin B主要用于科学研究, 探索心脏机制和潜在的治疗应用.
- 英文名称4-((3S,5R,8R,9S,10S,13R,14S,17R)-14-Hydroxy-3-(((2R,3S,4S,5S,6S)-3-Hydroxy-4-Methoxy-6-Methyl-5-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)-10,13-Dimethylhexadecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Furan-2(5H)-One
- 中文名称黄夹苷B
- IUPAC名称4-((3S,5R,8R,9S,10S,13R,14S,17R)-14-hydroxy-3-(((2R,3S,4S,5S,6S)-3-hydroxy-4-methoxy-6-methyl-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
- 其它别名3β-[4-O-[6-O-(β-D-Glucopyranosyl)-β-D-Glucopyranosyl]-6-Deoxy-3-O-Methyl-α-L-Glucopyranosyloxy]-14β-Hydroxy-5β-Card-20(22)-Enolide; 4)-6-Deoxy-3-O-Methyl-Alpha-L-Glucopyranosyl)Oxy]-14-Hydroxycard-20(22)-Enolide; (3Beta,5Beta)-3-[(O-Beta-D-Glucopyranosyl-(1-6)-O-Beta-D-Glucopyranosyl-(1-4)-6-Deoxy-3-O-Methyl-Alpha-L-Glucopyranosyl)Oxy]-14-Hydroxycard-20(22)-Enolide; Card-20(22)-Enolide, 3-[(O-β-D-Glucopyranosyl-(1→6)-O-β-D-Glucopyranosyl-(1→4)-6-Deoxy-3-O-Methyl-α-L-Glucopyranosyl)Oxy]-14-Hydroxy-, (3β,5β)-; Thevetin B Discontinued
- CAS编号27127-79-3
- MFCD编号:MFCD00869445
- FDA UNII编号:H77H03L5LQ
- 分子式:C42H66O18分子量:858.97
- 产品CID: 1250988
- 产品分类天然产物 → 甾体化合物
- 相似结构搜索
- 产品信息参考
- InChIKey: GZVMBXDQUQRICT-RCGIHWJFSA-N
- GZVMBXDQUQRICT-SOJOKHHINA-N
- 计算化学: 氢键受体数18.0氢键供体数9.0可旋转键数10.0
物理性质
上下游产品
4)-α-L-thevetosidedigitoxigenin β-D-gentiotriosyl-(1-4)-α-L-thevetoside17α-digitoxigenin合成工艺路线路线简述
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合成参考文献
参考文献:10.1016/0031-9422(91)83047-o
摘要:Abe F, Yamauchi T, Nohara T. C-nor-d-Homo-cardenolide glycosides fromThevetia neriifolia. Phytochemistry. 1992 Jan;31(1):251–4. doi: 10.1016/0031-9422(91)83047-o.
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