CAS: 2687-43-6; O-Benzylhydroxylamine Hydrochloride

上下游产品

N-benzyloxy benzamide 3-hydroxy-4-thi°Chromanone dimethylketal N-(benzyloxy)phthalimide 1-(benzyloxy)pyrrolidine-2,5-dioneO-benzyl oxime )heptanal-(O-benzyl oxime ) formaldehyde O-benzyloxime N,O-dibenzylhydroxylamine N,N,O-tribenzylhydroxylamine

Acetone O-Benzyloxime置于盐酸体系中,用 甲醇,水 用作溶剂,化学反应 3.5H,以98.72%的收率获得苄氧基胺盐酸盐
参考文献:一种苄氧胺盐酸盐的制备方法
标题:一种苄氧胺盐酸盐的制备方法
摘要:本申请公开了一种苄氧胺盐酸盐的制备方法.所述制备方法包括以下步骤:(1)在50~55oc的温度和100~120Rpm的搅拌速度下将酮肟2和碱金属氢氧化物分散于二甲基乙酰胺和水的混合溶剂中;(2)向步骤(1)所得的分散体中滴加卤化苄化合物1,滴加完成后在60~65oc的温度下反应130~140分钟,之后冷却至室温,加水,用正己烷萃取,将有机相减压蒸馏得到产物3;以及(3)将步骤(2)所得的产物3加入到甲醇和38%质量浓度的盐酸溶液的混合溶液中,在35~40oc的温度和80~100Rpm的搅拌速度下反应200~220分钟,然后减压蒸馏至有固体析出,冷却至室温,固体用石油醚洗涤,干燥,得到目标产物4苄氧胺盐酸盐.根据本发明的制备方法的总产率可达95%以上,产物纯度可达99%以上.

专利信息

专利号:US-6063919-A
优先权日:1998-08-14
标题:Process for the synthesis of exochelins
发明人：GAUDIOSO LARRY A; WEGLARZ MICHAEL A
权利人:KEYSTONE BIOMEDICAL INC
摘要:A process for the synthesis of an Exochelin comprising the steps of generating L-N-[(2-benzyloxy-(benzoyl)] serine or L-N-[2-benzyloxy (benzoyl)] threonine, creating L-N-t-Boc- epsilon -hydroxynorleucine and reacting same to produce L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester, providing a dicarboxylic acid and forming an O-benzyl methyl hydroxamate from the dicarboxylic acid, coupling the O-benzyl methyl hydroxamate with the L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester to give an L-N2-Boc-N6-methyl,N6-(benzyloxy) lysine 2-trimethylsilylethyl ester which incorporates the dicarboxylic acid as modified above, removing the N-tert-butoxycarbonyl protecting group from the L-N2-Boc-N6-methyl, N6-(benzyloxy) lysine 2-trimethylsilylethyl ester to yield a substituted lysine, and coupling the same with the L-N-[2-benzyloxy (benzoyl) serine or -threonine to yield a 2-trimethyl silylethyl ester of dibenzyl Exochelic acid, transforming the 2-trimethyl silylethyl ester of dibenzyl Exochelic acid to dibenzyl Exochelic acid, preparing benzyl epi-cobactin, forming an ester bond between the dibenzyl Exochelic acid and benzyl epi-cobactin to form an intermediate, and, hydrogenolytically removing three benzyl groups from said intermediate, resulting in the synthesized Exochelin. More particularly, a synthesis for Exochelin 786SM (R) is disclosed wherein the dicarboxylic acid is suberic acid and the serine form is utilized.

专利号:WO-9419366-A1
优先权日:1993-02-26
标题 :Chemical synthesis of squalamine
发明人：MORIARTY ROBERT M; GUO LIANG; TULADHAR SUDERSAN M
权利人:MAGAININ PHARMA
摘要:Methods for the chemical preparation or synthesis of the sterol antibiotic squalamine. Preferably, the preparation is by modifying the 3-position of a 3-oxo-7α-hydroxy-24z-ether protected alcohol group-5α-cholestane with a spermidino moiety to form a 3β-spermidino-7α-hydroxy-24z-ether protected group -5α-cholestane; deprotecting the 24-position of the 3β-spermidino-7α-hydroxy-24z-ether protected group-5α-cholestane to the free hydroxyl; and sulfating the 24-position of the 3β-spermidino-7α, 24-dihydroxy-5α-cholestane.

专利号:US-2025101006-A1
优先权日:2022-01-31
标题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents
发明人：BAENZIGER MARKUS; GALLOU FABRICE; GUO FENGFENG; HÄNGGI RUDOLF; HAN ENJIAN; JORDINE GUIDO; LI JIALIANG; LIU WEIPENG; MIAO BUKEYAN; RONG SHAOFENG; SANTANDREA ERNESTO; SCHIRNER PAUL BERND; SHEN XIAODONG; WANG CAN; ZHANG HAO
权利人:NOVARTIS AG
摘要:The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.

专利号:US-6887887-B2
优先权日:2001-03-19
标 题:Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor
发明人：BORNMANN WILLIAM G; SIROTNAK FRANCIS; SCHER HOWARD; VIDAL EPHRAIM; BORELLA CHRISTOPHER; SCHEINBERG DAVID
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides methods for the asymmetric synthesis of (S,S,R)-(−)-actinonin and its analogs and the compounds thereby synthesized having a structural formula: n n nwhere R 1 is an optionally substituted or halogenated alkyl, aryl, heteroalkyl or heteroaryl amine, said R 1 further comprising a cyclic or bicyclic structure; R 2 is methyl, CH 2 CH 3 , (CH 2 ) 2 CH 3 , C(CH 3 ) 3 , phenyl, 3,4-dichlorophenyl, biphenyl, benzyl, 4-hydroxybenzyl, piperidine, N-Boc-4-piperidine, CH 2 -(N-Boc-4-piperidine), 4-tetrahydropyran, CH 2 -4-tetrahydropyran, 3-methyl indolyl, 2-naphthyl, 3-pyridyl, 4-pyridyl, 3-thienyl; R 3 is R 2 or C 3-8 alkyl, R 4 is C 1-3 alkyl; and R 5 is NH 2 , OH, NHOH, NHOCH 3 , N(CH 3 )OH, N(CH 3 )OCH 3 , NHCH 2 CH 3 , NH(CH 2 CH 3 ), NHCH 2 (2,4-(OCH3) 2 Ph, NHCH 2 (4-NO 2 )Ph, NHN(CH 3 ) 2 , proline, or 2-hydroxymethyl pyrrolidine. Additionally, a method for the treatment of a neoplastic disease or for the inhibition of tumor cell growth each comprising the step of administering to an individual in need of such treatment a pharmacologically effective dose of the compounds of the present invention are provided.

专利号:US-5367113-A
优先权日:1991-10-30
标题 :Method for synthesis of desferrioxamine B, analogs and homologs thereof
发明人：BERGERON JR RAYMOND J
权利人:UNIV FLORIDA
摘要:Synthesis of desferrioxamine B and analogs and homologs thereof beginning with O-protected, N-protected hydroxylamine, which is N-alkylated to produce a protected N-4-cyanoalkylhydroxylamine which is acylated with a suitable anhydride. The resulting half-acid amide is subjected to a series of high yield condensations and reductions which vide desferrioxamine B in high overall yield. Alternatively, polyether analogs of desferrioxamine B can be prepared by reacting an activated polyether with the O-protected, N-protected hydroxylamine and subjecting the resulting product to a series of similar steps.

专利号:US-10717718-B2
优先权日:2015-11-17
标 题:5-azido-5-deoxy-2 :3-isopropylidene-D-arabinose compounds; their method of manufacture and their use for the synthesis of ARA-N3, KDO-N3 and 4EKDO-N3
发明人：VAUZEILLES BORIS; MAS PONS JORDI; BARON AURÈLIE
权利人:CENTRE NAT RECH SCIENT
摘要:Disclosed are new compounds of formulae: n nWherein: R 1 and R 2 can be independently H; a C 1 to C 6 alkyl including methyl, ethyl, propyl, butyl; aryl including phenyl, para-methoxyphenyl; or R 1 ,R 2 together with the carbon C-6 can be a cyclopentylidene or cyclohexylidene; each of these groups being substituted or not; and R 3 can be a C 1 to C 6 alkyl including methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl; or aryl including phenyl, methylphenyl, ethylphenyl, each of these groups being substituted or not. The invention also relates to their method of manufacture and their use for the synthesis of Ara-N 3 , Kdo-N 3 and 4eKdo-N 3 .