CAS: 2417-90-5; 3-Bromopropanenitrile

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CAS号109-78-4 3-羟基丙腈 | CAS号107-13-1 丙烯腈 | CAS号128-08-5 N-溴代丁二酰亚胺 | CAS号25840-11-3 propanenitrile | CAS号18505-84-5 1-Piperazinepro... | CAS号28509-46-8 4-溴丁-2-酮 | CAS号25176-72-1 Propanenitrile,... | CAS号27410-89-5 3(2H)-Benzothia... | CAS号25268-05-7 3-(2-Methylphen... | CAS号3055-86-5 3-苯氧基丙腈 | CAS号78-82-0 异丁腈 | CAS号3333-52-6 四甲基丁二腈 | CAS号107-13-1 丙烯腈

丙烯腈置于三(三甲基硅基)硅烷,1,2-二溴乙烷体系中,用 乙酸乙酯 用作溶剂,化学反应 18.0H,以100%的收率获得3-溴丙腈
参考文献:光诱导卤原子转移:卤化物自由基选择性卤化氢反应的生成
标题:光诱导卤原子转移:卤化物自由基选择性卤化氢反应的生成
摘要:描述了第一个能够通过卤素原子转移 (Xat) 产生卤化物自由基的光介导过程.这种新颖的反应模式依赖于使用 1,2-二卤乙烷通过 Xat 生成不稳定的碳自由基,Xat置于β 断裂后释放卤化物自由基,这些卤化物自由基已用于不饱和烃的选择性卤化氢.
Doi:10.1002/chem.202201495

专利信息

专利号:US-8101747-B2
优先权日:2009-03-31
标 题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD
权利人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERKIZ BERNARD; SERVIER LAB
摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.

专利号:US-5856500-A
优先权日:1997-03-11
标题:Synthesis of thiazole derivatives
发明人：MATTHEWS MICHAEL D; MALCOLM ARCELIO J
权利人:ALBEMARLE CORP
摘要:N- 4-(Cyanoethylthiomethyl)-2-thiazolyl!guanidine, is prepared by (a) mixing 1,3-dihaloacetone and 2-imino-4-thiobiuret in a suitable polar organic solvent at initial temperatures of about -10° to about 25° C., and agitating the mixture at about -10° to about 60° C. for at least about 1 hour; (b) heating the resultant mixture at about 40° to about 60° C. for at least about 0.5 hour; (c) mixing with the mixture from (b), thiourea and then water at about 40° to about 60° C. for a period of at least about 1 hour; (d) removing liquid polar solvent from the mixture of (c); and (e) mixing with the mixture from (d), 3-halopropionitrile and water-soluble alcohol, ether, or ether-alcohol, followed by aqueous alkali metal hydroxide while maintaining the temperature at below about 20° C., to form N- 4-(cyanoethylthiomethyl)-2-thiazolyl!guanidine. The process avoids isolating and purifying any of the intermediates, and can be conducted in the same vessel, as a 'one-pot' synthesis.

专利号:US-7671141-B2
优先权日:2005-06-30
标题:Second order nonlinear optical polyimides having benzobisthiazole-based pendant groups, and preparation of the same
发明人：HSU TZU-CHIEN; CHEN CHIEN-FAN; WU SHOU-SHIUN
权利人:UNIV NAT SUN YAT SEN
摘要:Disclosed herein are second order nonlinear optic polyimide polymers comprising repeating units represented by the formula: n nwherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation processes of these polymers, chromophore-forming compounds for synthesis of these polymers, and the intermediate polymers thereof. The second order nonlinear optic polyimide polymers of formula (I) may be used in the manufacture of electro-optic (EO) devices, such as electro-optic waveguide devices.

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-2010249397-A1
优先权日:2009-03-31
标 题:Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid