CAS: 21881-78-7; Diisopropyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
该化合物是属于衍生物类的化学化合物.该物质具有一种由多种功能组组成的环状,包括两个酯类和硝基苯细胞,有助于其化学反应和潜在应用.异丙基生物组的存在增强了其亲性,有可能影响其在有机溶剂中的溶性.硝基氨组引入了电子提取特性,可影响该化合物的再活性和与生物系统的互动.该化合物可能具有有趣的药用特性,成为医学化学领域进一步研究的候选物.其结构复杂性表明,各种化学合成物或更复杂的分子的形成过程中,其潜在用途是有用的.但是,应同任何化学物质一起咨询具体的安全和处理信息,以确保适当的实验室做法.
- 英文名称Diisopropyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
- 中文名称1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二甲酸二异丙酯
- IUPAC名称diisopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 其它别名1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid Bis(1-Methylethyl) Ester; Nimodipine Ep Impurity B; (Rs)-Di-Iso-Propyl-1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)Pyridine-3,5-Dicarboxylate; 3-Des(2-Methoxyethyl) 3-(1-Methylethyl) Ester Nimodipine; Nimodipine Impurity 2; Nimodipine Ep Imp B; 3,5-Diisopropyl 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylate; Nimodipine Impurity B Control
- CAS编号21881-78-7
- MFCD编号:MFCD00347775
- EINECS号:642-092-0
- FDA UNII编号:7DL8XRH66U
- 分子式:C21H26N2O6分子量:402.45
- 产品CID: 1137406
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
上下游产品
isopropyl 3-amin°Crotonate 3-oxo-2-(3-nitrophenylmethylene)butanoic acid isopropyl ester 2-methoxyethyl-3-oxobutanoate 3-nitro-benzaldehyde 3,5-diisopropyl 4-(3-aminophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate合成工艺路线路线简述
📜乙酰乙酸异丙酯置于氨,对甲苯磺酸体系中,用 乙醇,甲苯 用作溶剂,化学反应生成1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二甲酸二异丙酯
参考文献:Meyer; Bossert; Wehinger,Arzneimittel-Forschung/drug Research,1981,Vol. 31,# 3,P. 407-409
标题:Meyer; Bossert; Wehinger,Arzneimittel-Forschung/drug Research,1981,Vol. 31,# 3,P. 407-409
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2902700000-异丙基苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:1-Methylimidazolium Trifluoroacetate [hmim]Tfa: Mild And Efficient Brønsted Acidic Ionic Liquid For Hantzsch Reaction Under Microwave Irradiation作者:Jemin R Avalani,Devji S Patel,Dipak K Raval |发布日期:2012.9
摘要:One Pot Synthesis Of 1,4-Dihydropyridine Derivatives Was Achieved Via Condensation Of Various β-Ketoesters With Aromatic/aliphatic Aldehydes And Ammonium Acetate. The Reaction Was Catalysed By A Stable And Reusable Brønsted Acidic Ionic Liquid (Il), 1-Methyl-Imidazolium Trifluoroacetate ([hmim]Tfa), Under Microwave (Mw) Irradiation. The Synergistic Combination Of Mw With Il Can Potentially Go A Long
合成参考文献
参考文献:10.1016/j.bmc.2010.03.038
摘要:Chang CC, Cao S, Kang S, Kai L, Tian X, Pandey P, Dunne SF, Luan CH, Surmeier DJ, Silverman RB. Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2. Bioorg Med Chem. 2010 May 01;18(9):3147–58. doi: 10.1016/j.bmc.2010.03.038.
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