CAS: 2042-27-5; L-Ribulose

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CAS号5328-37-0 L-阿拉伯糖 | CAS号7643-75-6 L-(-)-阿拉伯糖醇 | CAS号488-81-3 侧金盏花醇 | CAS号527-50-4 L-木酮糖 | CAS号5328-37-0 L-阿拉伯糖 | CAS号5985-95-5 4-(3,4-dihydrox...

📜L-(+)-Arabinose置于sodium Nitrate,Sodium Tetrahydroborate,Pyranose 2-Oxidase T169G Mutant,氧气体系中,用 Aq. Phosphate Buffer 用作溶剂,化学反应 2.0H,反应生成L-核酮糖
参考文献:在酶促级联反应中,将一阿拉伯糖一锅生物转化为一核糖.
标题:在酶促级联反应中,将一阿拉伯糖一锅生物转化为一核糖.
摘要:这项工作报告了一锅法式酶联反应级联反应,它利用吡喃糖2-氧化酶(p2O),木糖还原酶,甲酸脱氢酶和过氧化氢酶催化的四个反应将l-阿拉伯糖完全转化为l-核糖.由于野生型p2O对六碳糖的氧化具有特异性,因此在合理设计的基础上生成了一系列p2O变体,以改变酶对l氧化的特异性.C2位置的阿拉伯糖.T169G变体被认为是最佳候选者,与野生型酶相比,其黄素还原(糖氧化)步骤的速率常数高约40倍.使用量子力学/分子力学(qm / Mm)分子动力学(md)进行的计算表明,这种改进是由于l-阿拉伯糖在轴向c4-Oh处的空间效应减少,从而缩短了两者之间的距离c2-H和黄素n5,促进氢化物转移并降低黄素含量.
Doi:10.1002/anie.201814219

专利信息

专利号:US-2022395800-A1
优先权日:2019-11-04
标题:Device for automated synthesis of oligo- and polysaccharides
发明人：SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO
权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A
摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

专利号:US-2019315790-A1
优先权日:2016-11-11
标题:Synthesis of d-allulose
发明人：KOCH TIMO JOHANNES; KIPPING FLORIAN; BUTZ STEFFEN; LESCH MARCEL; HÄSSLER THOMAS
权利人:PFEIFER & LANGEN GMBH & CO KG
摘要:The invention relates to a process for the synthesis of a product saccharide, preferably of D-allulose from an educt saccharide, preferably from D-fructose under heterogeneous or homogeneous catalysis which includes chemical and/or enzymatic catalysis. The synthesis is performed in at least two reactors that are arranged in series and the reaction product exiting the first reactor is subjected to chromatographic separation before it enters the second reactor. Preferably, the chromatographic separation is integrated in a simulated moving bed.

专利号:EP-3835306-A1
优先权日:2019-12-13
标题:Microwave-assisted method for synthesis of oligo- and polysaccharides on solid phase
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a method for synthesizing oligo- and polysaccharides using microwave radiation, in particular to a method and a device for automated synthesis of oligo- and polysaccharides.

专利号:US-7102018-B2
优先权日:1998-05-25
标 题 :Intermediates and improved processes for the preparation of neplanocin A
发明人：YOSHIDA NAOYUKI; OGASAWARA KUNIO
权利人:CHISSO CORP
摘要:Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)dioxy]-5-hydroxy-tricyclo[5.2.1.0 2,6 ]dec-8-ene, which are useful for the synthesis of neplanocin A having strong antitumor activity. Improved processes for the preparation of neplanocin A, starting from optically active 2-hydroxymethyl-5-hydroxy-tricyclo[5.2.1.0 2,6 ]deca-3,8-diene and via a key step comprising a retro-Diels-Alder reaction of the above intermediate.

专利号:US-7053225-B2
优先权日:1998-05-25
标题:Intermediates and improved processes for the preparation of neplanocin A
发明人：YOSHIDA NAOYUKI; OGASAWARA KUNIO
权利人:CHISSO CORP
摘要:Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)dioxy]-5-hydroxy-tricyclo[5.2.1.0 2,6 ]dec-8-ene, which are useful for the synthesis of neplanocin A having strong antitumor activity. Improved processes for the preparation of neplanocin A, starting from optically active 2-hydroxymethyl-5-hydroxy-tricyclo[5.2.1.0 2,6 ]deca-3,8-diene and via a key step comprising a retro-Diels-Alder reaction of the above intermediate.

专利号:US-9719098-B2
优先权日:2011-04-05
标 题:Methods for the improvement of product yield and production in a microorganism through the addition of alternate electron acceptors
发明人：ARGYROS AARON; SILLERS WILLIAM RYAN; BARRETT TRISHA; CAIAZZA NICKY; SHAW IV ARTHUR J
权利人:LALLEMAND HUNGARY LIQUIDITY MAN LLC
摘要:The present invention provides for novel metabolic pathways to reduce or eliminate glycerol production and increase product formation. More specifically, the invention provides for a recombinant microorganism comprising a deletion of one or more native enzymes that function to produce glycerol and/or regulate glycerol synthesis and one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to convert a carbohydrate source, such as lignocellulose, to a product, such as ethanol, wherein the one or more native and/or heterologous enzymes is activated, upregulated, or downregulated. The invention also provides for a recombinant microorganism comprising one or more heterologous enzymes that function to regulate glycerol synthesis and one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to convert a carbohydrate source to ethanol, wherein said one or more native and/or heterologous enzymes is activated, upregulated or downregulated.