1,4-二氟苯,乙酰氯置于三氯化铝体系中,化学反应生成2,5-二氟苯乙酮 参考文献:2,3-Difluorostyrene And 2-Chloro-5-Fluorostyrene. The Preparation Of Aromatic Fluorine Compounds 标题:2,3-Difluorostyrene And 2-Chloro-5-Fluorostyrene. The Preparation Of Aromatic Fluorine Compounds 摘要: Doi:10.1021/jo01062A067
专利号:US-5059709-A 优先权日:1990-11-13 标题 :Process for the synthesis of α-[(dialkylamino)substituted-methylene]-β-oxo-(substituted)propanentriles 发明人:DUSZA JOHN P; CHURCH ROBERT F 权利人:AMERICAN CYANAMID CO 摘要:A novel process for producing α-[(dialkylamino) substituted-methylene]β-oxo-(substituted) propanenitriles of the formula: ##STR1## where R, R 1 and R 2 are defined in the specification by reacting a substituted isoxazole with a diaklylamide dimethylacetal is provided.
专利号:CN-111019915-A 优先权日:2019-11-08 标 题:Application of carbonyl reductase mutants in the synthesis of chiral ortho-halogenated-α-phenylethanol
专利号:CN-111019915-B 优先权日:2019-11-08 标题:Application of carbonyl reductase mutants in the synthesis of chiral ortho-halogenated-α-phenylethanol
专利号:US-5734067-A 优先权日:1994-09-28 标题 :Anti-oxidative tricyclic, condensed heterocyclic compound 发明人:JINNO SHUJI; KOGURE YASUYO; ONUKI HIROYUKI; OKITA TAKAAKI 权利人:NIPPON SUISAN KAISHA LTD 摘要:Providing a novel tricyclic, condensed heterocyclic compound having an anti-oxidative action and being promising for use in pharmaceutical agents, cosmetics, chemical products and the like. By chemical synthesis, a novel anti-oxidative, tricyclic, condensed heterocyclic compound represented by the following formula: ##STR1## (wherein X--Y represents CH 2 --Câ•?O, CH 2 --CH 2 or CHâ•?CH; Z represents O, S, or Sâ•?O; R 1 to R 8 represent independently those selected from the group consisting of hydrogen atom, a hydroxyl group, a halogen group, a lower alkyl group, a lower alkoxyl group, a lower alkyl ketone group and CF 3 ; and at least two of R 1 to R 4 are hydroxyl groups); and the salts thereof are provided. The compound has an anti-oxidative activity at the same degree as or higher than the activity of α-tocopherol, so the compound is promising as a therapeutic drug for a variety of diseases, such as cancer, arteriosclerosis, or liver diseases, in which it is believed that biological lipid peroxides may b involved.