CAS: 167993-00-2; (S)-2-((Tert-Butoxycarbonyl)Amino)-3-(2,4-Difluorophenyl)Propanoic Acid

该化合物是一种手性氨基酸衍生物,含有一种受Boc保护的矿物质组和2,4-二氟苯基侧链.该化合物是有机合成中有价值的中间体,特别是在浸泡物化学和制药研究中.乙型丁氧基碳基(Boc)组为矿物质功能提供选择性保护,在温酸条件下进行有控制的去保护.2,4-二氟基分子会增强消毒和电子特性,使其有助于改变生物活性分子.其高纯度和定义明确的立体化学学确保合成应用的再生性.这一构件对于发展氟聚苯乙烯和小型分子治疗特别相关.

英文名称(S)-2-((Tert-Butoxycarbonyl)Amino)-3-(2,4-Difluorophenyl)Propanoic Acid
中文名称(S)-2-((叔丁氧基羰基)氨基)-3-(2,4-二氟苯基)丙酸
其它别名Boc-L-2,4-二氟苯丙氨酸; Boc-2,4-Difluoro-L-Phenylalanine
CAS编号167993-00-2
MFCD编号:MFCD07371996
分子式:C14H17F2NO4分子量:301.29
产品CID: 849274
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: JNELGIOSRKVOJY-NSHDSACASA-N
1S/C14H17F2NO4/c1-14(2,3)21-13(20)17-11(12(18)19)6-8-4-5-9(15)7-10(8)16/h4-5,7,11H,6H2,1-3H3,(H,17,20)(H,18,19)/t11-/m0/s1
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数4.0

相似化合物

167993-24-0 1217820-78-4 31105-93-8

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H320-H335
防范说明P261-P280-P302+P352

上下游产品

tert-butyl dicarbonatedi-tert-butyl dicarbonate 2,4-difluoro phenylalanine 1-(bromomethyl)-2,4-difluorobenzene 2-acetylamino-3-(2,4-difluoro-phenyl)-propionic acid

合成工艺路线路线简述

📜2,4-二氟溴苄置于sodium Hydroxide,Aspergillus Genus Acylase,Sodium Ethanolate,Sodium Acetate体系中,用甲醇,乙醇,对二甲苯,水用作溶剂,化学反应 55.0H,反应生成Boc-24-二氟-L-苯基丙氨酸
参考文献:Synthesis Of A Complete Set Of L-Difluorophenylalanines,L-(F2)Phe,As Molecular Explorers For The Ch/π Interaction Between Peptide Ligand And Receptor
标题:Synthesis Of A Complete Set Of L-Difluorophenylalanines,L-(F2)Phe,As Molecular Explorers For The Ch/π Interaction Between Peptide Ligand And Receptor
摘要:A Complete Set Of Difluorophenylalanines In The L-Configuration [l-(F-2)Phe] (Namely,L-(2,3-F-2)Phe,L-(2,4F(2))Phe,L-(2,5-F-2)Phe,L-(2,6-F-2)Phe,L-(3,4-F-2)Phe,L-(3,5-F-2)Phe) Was Prepared And Incorporated Into The Thrombin Receptor-Tethered Ligand Peptide Sfllrnp To Identify The Phenyl Hydrogens Of The Phe-2 Residue Involved In The Ch/pi Receptor Interaction. (C) 2000 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0040-4039(99)02191-7