CAS: 1677-80-1; 3,4-Dichloropyridazine

相似化合物

6082-66-2 14161-11-6 20074-67-3

上下游产品

4-chloropyridazin-3-ol 3-hydroxypyridazine 3-chloro-6-phenoxy-pyridazine

📜3-哒嗪酮置于4-二甲氨基吡啶,氯化亚砜,三光气体系中,化学反应 10.0H,以85%的收率获得3,4-二氯哒嗪
参考文献:氮杂氮杂戊烯的高效无磷氯化反应及其在一锅法药物合成中的应用
标题:氮杂氮杂戊烯的高效无磷氯化反应及其在一锅法药物合成中的应用
摘要:用碳酸二(三氯甲基)酯(btc)和socl 2氯化羟基氮杂芳烃已经通过与5重量%的4-二甲基氨基吡啶(dmap)作为催化剂回流而有效地进行.各种底物都可以高产率氯化.所获得的氯化氮杂芳烃可通过简单的后处理直接直接用于大规模的一锅合成.
Doi:10.1021/acs.Oprd.9B00407

专利信息

专利号:US-9968612-B2
优先权日:2012-09-17
标题:Method of synthesizing thyroid hormone analogs and polymorphs thereof
发明人：TAUB REBECCA; REYNOLDS CHARLES H
权利人:MADRIGAL PHARMACEUTICALS INC
摘要:The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:WO-2024256360-A1
优先权日:2023-06-12
标题 :Method and system for calculating mass flow and estimating sustainability metrics in chemical synthesis
发明人：HAENSEL HELMUT; WIRSING SARA; BATHE ANDREAS; DAUTH ALEXANDER; KUEHNE BENJAMIN; BECKER HEINRICH; HELL KERSTIN
权利人:MERCK PATENT GMBH
摘要:A method is disclosed that selects one or more experimental IDs from an electronic notebook. The method links the one or more experimental IDs to form an integrated process to synthesize a target material and estimate a plurality of process metrics wherein each of the plurality of process metrics corresponds to a respective experimental ID of the one or more experimental IDs. The method estimates an aggregate process metric corresponding to the integrated process. The aggregate process metric is a function of the estimated plurality of process metrics. The method provides a synthesis tree corresponding to the one or more experimental IDs and searches for similar reaction subprocesses for each of the experimental IDs to determine a plurality of similar experiments. The method also selects an alternative experimental ID for at least one of the one or more experimental IDs and updates the aggregate process metric in accordance with the alternative experimental ID.

专利号:FR-2692576-A1
优先权日:1992-06-23
标题 :Pyridazines, their synthesis and their application to the synthesis of minaprine and minaprine derivatives.

专利号:WO-2008132314-A2
优先权日:2007-03-30
标题 :Method for the synthesis of cubic metal nanoparticles in the presence of two reducers