CAS: 1664-98-8; Dideuteriomethanone

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CAS号1849-29-2 甲醇-d3 | CAS号811-98-3 氘代甲醇 | CAS号269391-78-8 2,4,6-trichloro... | CAS号79825-55-1 dideuterio-hydr... | CAS号133-38-0 二羟基富马酸 | CAS号50-00-0 甲醛 | CAS号2219-51-4 乙二醇 | CAS号6552-57-4 氧化乙烯-D4 | CAS号3996-15-4 甲酸钠-D | CAS号23304-08-7 六亚甲基四胺-d12 | CAS号2914-27-4 N,N-二甲基甲酰胺-d1 | CAS号28563-35-1 甲烷-d2-醇 | CAS号1849-29-2 甲醇-d3 | CAS号82414-60-6 季戊四醇-d8 | CAS号107-31-3 甲酸甲酯 | CAS号23731-38-6 氘代甲酸甲酯 | CAS号74848-84-3 Thymidine-d3 | CAS号35434-71-0 trimethyl-d8-amine

📜氘代甲醇置于sodium Hypochlorite,(Et4N)2[feiii(Cl)(Biuret-Taml)]体系中,用 Aq. Phosphate Buffer,乙腈 用作溶剂,化学反应生成甲醛-D2
参考文献:Fe-Btaml和naclo催化氧化酒精:比较fe(v)o和fe(iv)o中间体的反应性
标题:Fe-Btaml和naclo催化氧化酒精:比较fe(v)o和fe(iv)o中间体的反应性
摘要:摘要我们证明了以fe-Btaml为催化剂,以次氯酸钠(naclo)为氧化剂将仲醇和活化的伯醇选择性氧化为相应的醛或酮.羰基化合物的收率好至极好,达到80%-99%,使用该催化系统可获得高达〜500的周转率.反应是干净的,在温和的条件下(空气,室温)进行,并且产生的氯化钠是唯一的副产物.产率和周转数取决于反应的ph,并且该差异归因于在ph 7和ph 12下分别形成的反应性中间体(分别为fev(o)和feiv(o)).涉及fev(o)中间体的反应比其feiv(o)类似物更有效地氧化仲醇.对于活化的伯醇的氧化,这种趋势被逆转了,其中涉及feiv(o)的反应提供了更高的ton.这种反应性趋势也可以通过其相应的一种电子还原物种([feiv-Oh],〜99 Kcal / Mol; [feiii-Oh],〜83 Kcal / Mol)的键离解能(bde)的差异来解释.是它们在反应过程中在溶剂中的相对稳定
Doi:10.1016/j.Ica.2018.10.067

专利信息

专利号:US-7205427-B2
优先权日:2002-06-04
标 题:Cross-coupling synthesis of alkyl (dialkylphenyl) indenes
发明人：BARNES HAMLIN H
权利人:BOULDER SCIENT CO
摘要:A cross-coupling synthesis of 2-alkyl-4-(2,6-dialkylphenyl)indenes is described. A 2-alkylidene is treated with a dialkylboronic acid in the presence of a catalyst. A feature of the invention is the use of a cross-coupling catalyst comprising palladium dichloride (1,5-cyclooctadiene) as a cross-coupling catalyst.

专利号:US-7271231-B2
优先权日:1995-01-24
标 题 :Polymerization of olefins
发明人：BROOKHART MAURICE S; JOHNSON LYNDA KAYE; KILLIAN CHRISTOPHER MOORE
权利人:DU PONT
摘要:Disclosed herein are processes for polymerizing ethylene, acyclic olefins, and/or selected cyclic olefins, and optionally selected olefinic esters or carboxylic acids, and other monomers. The polymerizations are catalyzed by selected transition metal compounds, and sometimes other co-catalysts. Since some of the polymerizations exhibit some characteristics of living polymerizations, block copolymers can be readily made. Many of the polymers produced are often novel, particularly in regard to their microstructure, which gives some of them unusual properties. Numerous novel catalysts are disclosed, as well as some novel processes for making them. The polymers made are useful as elastomers, molding resins, in adhesives, etc. Also described herein is the synthesis of linear α-olefins by the oligomerization of ethylene using as a catalyst system a combination a nickel compound having a selected α-diimine ligand and a selected Lewis or Bronsted acid, or by contacting selected α-diimine nickel complexes with ethylene.

专利号:US-7968519-B2
优先权日:1998-03-19
标 题 :Methods and compositions for controlled polypeptide synthesis
发明人：DEMING TIMOTHY J; YU MIAOER; CURTIN SCOTT A; HWANG JUNGYEON; WYRSTA MICHAEL D; NOWAK ANDREW; SEIDEL SCOTT W
权利人:UNIV CALIFORNIA
摘要:Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

专利号:US-2025250234-A1
优先权日:2022-04-12
标 题:Fluoroalcohols as co-solvents for chemical synthesis and methods for producing the same
发明人：COLBY DAVID; ISLAM BAHARUL
权利人:UNIV MISSISSIPPI
摘要:In one aspect, the disclosure relates to a method for the in situ generation of formaldehyde for the hydroxymethylation of difluoroenolates to create 2,2-difluoroethanols having a range of solubilities, acidity, basicity, and other physical properties. The method also allows the production of formaldehyde-d 2 for hydroxy deuteromethylations and constitutes a new synthetic method for 2,2-difluoro-1,1-deuteroethanols. In one aspect, disclosed method is compatible with α,α-difluorobenzyl carbanions generated from the release of trifluoroacetate from electron-deficient aromatic and heteroaromatic rings and can be conducted under mild conditions with high yields. Also disclosed herein are 2,2-difluoroethanols generated by the disclosed method and methods of using the 2,2-difluoroethanols as solvents or co-solvents for organic synthesis, metal catalyzed reactions, asymmetric processes, carbohydrate chemistry, and medicinal chemistry.

专利号:US-11408897-B2
优先权日:2015-10-14
标 题:Mass defect-based multiplex dimethyl pyrimidinyl ornithine (DiPyrO) tags for high-throughput quantitative proteomics and peptidomics
发明人：LI LINGJUN; FROST DUSTIN; BUCHBERGER JONES AMANDA
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The use of mass defect signatures to impart milliDalton mass differences between isotopically labeled peptides at the MS1-level allows multiplex quantification without the increased mass spectral complexity that occurs with mass difference approaches. Provided herein is a mass defect-based chemical tag, dimethyl pyrimidinyl ornithine (DiPyrO), that is compact and easy to synthesize at high purity in few steps using commercially available starting materials. The multiplex DiPyrO tags are amine-reactive and can impart a mass difference onto labeled peptides and through calculated substitution of heavy isotopes. DiPyrO offers up to 10-plex quantification on current Orbitrap or FT-ICR platforms without increasing mass spectral complexity. The synthesis of the DiPyrO tag is provided along with viability of the DiPyrO tag for labeling complex proteomics samples using yeast extract digests and its effect on labeled peptides during LC-MS2 analysis. Labeling and quantification of glycans and metabolites using the DiPyrO tag is also demonstrated.

专利号:US-8067394-B2
优先权日:2006-11-17
标 题:Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
发明人：HONDA TADASHI; SUNDARARAJAN CHITRA; GRIBBLE GORDON W; SPORN MICHAEL B; LIBY KAREN T
权利人:HONDA TADASHI; SUNDARARAJAN CHITRA; GRIBBLE GORDON W; SPORN MICHAEL B; LIBY KAREN T; DARTMOUTH COLLEGE
摘要:This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The inventors demonstrate the ability of these new TBEs to inhibit proliferation of human myeloma cells, inhibit the induction of iNOS in cells stimulated with interferon-γ, induce heme oxygenase-1 (HO-1), induce CD11b expression—a leukemia differentiation marker, inhibit proliferation of leukemia cells, induce apoptosis in human lung cancer, and induce apoptosis in other cancerous cells. The TBEs of this invention are expected to be useful agents for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.