CAS: 1514-96-1; 4-Chloro-2-(Trifluoromethyl)Pyrimidine

相似化合物

705-24-8 1816289-02-7 1582-25-8

上下游产品

2-trifluoromethyl-4-hydroxypyrimidine 2-trifluoromethyl-4,6-dihydroxypyrimidine 4,6-dichloro-2-(trifluoromethyl)pyrimidine 1-(2-trifluoromethyl-4-pyrimidinyl)piperazine 4-{[2-(trifluoromethyl)pyrimidin-4-yl]oxy}aniline 1-(2-(trifluoromethyl)pyrimidin-4-yl)ethanone (R)-N-(4-cyanophenylethyl)-1-(2-(trifluoromethyl)pyrimidin-6-yl)piperidine-3-carboxamide

4,6-二氯-2-三氟甲基嘧啶置于palladium 10% On Activated Carbon,氢溴酸,氢气,三乙胺,三氯氧磷体系中,用 甲醇 用作溶剂,105.0 °C,101.33 Kpa 条件下,反应 28.0H,反应生成2-三氟甲基-4-氯嘧啶
参考文献:一种4-氯-2-三氟甲基嘧啶的制备方法
标题:一种4-氯-2-三氟甲基嘧啶的制备方法
摘要:本发明公开了一种4‑氯‑2‑三氟甲基嘧啶(式i)的制备方法,通过价格低廉,易购的三氟乙酸甲酯与丙二酰胺为原料制备.该方法没有使用到昂贵的物料,反应条件温和,设备简单,Ehs风险小,成本低廉,适于规模化生产.

专利信息

专利号:US-4963678-A
优先权日:1989-10-27
标题 :Process for large-scale production of BMY 21502
发明人：MADDING GARY D; MINIELLI JOSEPH L; MATTSON RONALD J
权利人:BRISTOL MYERS SQUIBB CO
摘要:An improved process, suitable for adaption to large-scale manufacture for synthesis of the cerebral function enhancing agent BMY 21502.

专利号:EP-3686190-A1
优先权日:2013-07-11
标 题 :Synthesis of therapeutically active compounds