CAS: 13498-14-1; Diphosphoryl Chloride

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CAS号7732-18-5 水 | CAS号10025-87-3 三氯氧磷 | CAS号10026-13-8 五氯化磷 | CAS号13779-49-2 dichlorophospho... | CAS号12185-10-3 黄磷 | CAS号80937-33-3 oxygen | CAS号7782-50-5 氯气 | CAS号20667-12-3 氧化银 | CAS号10544-73-7 三氧化二氮 | CAS号7719-12-2 三氯化磷 | CAS号10025-87-3 三氯氧磷 | CAS号10043-91-1 diaminophosphin... | CAS号25758-26-3 phosphoric acid... | CAS号13455-03-3 phosphoryl brom... | CAS号7789-59-5 三溴氧磷 | CAS号7647-01-0 盐酸 | CAS号1623-14-9 磷酸单乙基酯 | CAS号7664-38-2 磷酸 | CAS号14000-31-8 Diphosphate

三氯氧磷置于p体系中,用 Neat (No Solvent) 用作溶剂,化学反应生成四氯三氧化二磷
参考文献:Reinitzer,B.; Goldschmidt,H.,Chemische Berichte,1880,Vol. 13,P. 845-851
标题:Reinitzer,B.; Goldschmidt,H.,Chemische Berichte,1880,Vol. 13,P. 845-851

专利信息

专利号:WO-2024185734-A1
优先权日:2023-03-03
标 题:Polyphosphorylated nucleoside, phosphate-activated nucleotide used for synthesis of polyphosphorylated nucleoside and method for synthesis of same, and method for synthesis of polyphosphorylated nucleoside using phosphate-activated nucleotide
发明人：KATAOKA MASANORI; FUKUI CHIHARU; TSUJI YOHEI; FUJIMURA Kazuma
权利人:NATIAS INC
摘要:The present invention provides: a polyphosphorylated nucleoside which has a structure represented by formula (I) and can be efficiently produced by a short process and a simple operation with use of a less expensive material; a phosphate-activated nucleotide which is used for the synthesis of the polyphosphorylated nucleoside and a method for the synthesis of this phosphate-activated nucleotide; and a method for the synthesis of a polyphosphorylated nucleoside using a phosphate-activated nucleotide. In the formula, B represents a protected or unprotected, natural or artificial nucleoside base; R 1 , R 2 , R 4 and R 5 each represent H or an alkyl group or the like, and R 1 , R 2 , R 4 and R 5 may be the same as or different from each other; X and Y each represents H, OH, OCH 3 or the like; h represents an integer of 1 to 3; p, n, m and q each represent 0 or an integer, and p, n, m and q are in no particular order; and (p + n + m + q) is an integer of 0 to 5,000.

专利号:US-7091334-B2
优先权日:1997-07-25
标题 :Method for large-scale production of di(uridine 5′)-tetraphosphate and salts thereof
发明人：YERXA BENJAMIN R; PENDERGAST WILLIAM
权利人:INSPIRE PHARMACEUTICALS INC
摘要:The present invention provides new methods for the synthesis of the therapeutic dinucleotide, P 1 ,P 4 -di(uridine 5′)-tetraphosphate, and demonstrates applicability to the production of large quantities. The methods of the present invention substantially reduce the time period required to synthesize diuridine tetraphosphate, preferably to three days or less. The novel tetrammonium and tetrasodium salts of P 1 ,P 4 -di(uridine 5′)-tetraphosphate (Formula I) prepared by these methods are stable, soluble, nontoxic, and easy to handle during manufacture. n nwherein:n X is Na, NH 4 or H, provided that all X groups are not H.

专利号:US-4266048-A
优先权日:1977-10-11
标题:Synthesis of analogs of 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
发明人：HORWITZ JEROME P; NEENAN JOHN P; MISRA RADHEY S; ROZHIN JURIJ; HUO ANNE; PHILIPS KERSTIN D
权利人:US HEALTH EDUCATION & WELFARE
摘要:Analogs of 3'-phosphoadenosine 5'-phosphosulfate, also known as PAPS, are useful in establishing sulfate transfer mechanisms in animals and may be produced by a chemical process yielding an analog B of a pure adenosine 2',3'-cyclic phosphate 5'-phosphate, which compound is initially prepared from the reaction of adenosine and pyrophosphoryl chloride. In the present process an analog B is selected from 8-bromoadenine, purine, hypoxanthine, 4-aminopyrrolo[2,3-d]pyrimidine (tubercidin), and 7-amino-pyrazolopyrimidine (formycin). In the pilot procedure the pure cyclic phosphate is reacted with triethylamine-N-sulfonic acid to produce 2',3'-cyclic phosphate 5'-phosphosulfate. Subsequently, by hydrolysis with the enzyme ribonuclease-T 2 , the desired compound, an analog of PAPS, is produced. Alternatively, the 2'-phosphoadenosine 5'-phosphosulfate, known as iso-PAPS, may be produced from 2',3'-cyclic phosphate 5'-phosphosulfate by treatment with a different enzyme, PDase II or spleen phosphodiesterase.

专利号:US-6319908-B1
优先权日:1996-07-03
标题 :Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof
发明人：YERXA BENJAMIN R; PENDERGAST WILLIAM
权利人:INSPIRE PHARMACEUTICALS INC
摘要:The present invention provides new methods for the synthesis of the therapeutic dinucleotide, P 1 ,P 4 -di(uridine 5′-tetraphosphate), and demonstrates applicability to the production of large quantities. The methods of the present invention substantially reduce the time period required to synthesize diuridine tetraphosphate, preferably to three days or less. The novel tetrammonium and tetrasodium salts of P 1 ,P 4 -di(uridine 5′-tetraphosphate) (Formula I) prepared by these methods are stable, soluble, nontoxic, and easy to handle during manufacture, n wherein: n X is Na, NH 4 or H, provided that all X groups are not H.

专利号:US-4169011-A
优先权日:1977-10-11
标题:Facile synthesis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
发明人：HORWITZ JEROME P; NEENAN JOHN P; MISRA RADHEY S; ROZHIN JURIJ; HUO ANNE L; PHILIPS KIRSTEN D
权利人:US HEALTH EDUCATION & WELFARE
摘要:3'-Phosphoadenosine 5'-phosphosulfate, also known as PAPS, is useful in establishing sulfate transfer mechanisms in animals and may be produced by a chemical process yielding 68-72% product from a pure adenosine 2',3'-cyclic phosphate 5'-phosphate, which compound is initially prepared from the reaction of adenosine and pyrophosphoryl chloride. In the present procedure the pure cyclic phosphate is reacted with triethylamine-N-sulfonic acid to produce 2',3'-cyclic phosphate 5'-phosphosulfate. Subsequently, by hydrolysis with the enzyme ribonuclease-T 2 , the desired compound is produced. Alternatively, the 2'-phosphoadenosine 5'-phosphosulfate, known as iso-PAPS, may be produced from 2',3'-cyclic phosphate 5'-phosphosulfate by treatment with a different enzyme, PDase or spleen phosphodiesterase. This latter compound, iso-PAPS, biologically has only one-third the activity of PAPS, the natural isomer.

专利号:US-5506352-A
优先权日:1993-02-01
标 题:Process for the synthesis of 9-(β-D-arabinofuranosyl)adenine, 5'-phosphate
发明人：BUTLER DONALD E; MILLAR ALAN
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of 9-(β-D-arabinofuranosyl)adenine, 5'-phosphate, is described where dried 9-(β-D-arabinofuranosyl)adenine is reacted with triethyl phosphate and phosphorous oxychloride in dichloromethane and the reaction mixture hydrolyzed and excess hydrogen chloride removed with propylene oxide as the acid scavenger. This process gives a yield of about 70-85%, which is nearly double the yields of the prior art.