CAS: 13159-28-9; Betulinicaldehyde

该化合物其结构特征为缺水三叶基骨,影响其溶性及其与生物膜的相互作用.此外,甲可进行各种化学变异,使其能够作为合成其他生物活性化合物的前体.该化合物的潜在应用范围扩大到化妆品和食品保护领域,其天然来源和有益特性特别具有价值.

结构式图片

物理性质

MSDS等安全信息

    上下游产品

    3-O-acetylbetulinal Betulinic acid betulin (3β)-3-acetyloxy-N-methoxy-N-methyl-lup-20(29)-en-28-amideBetulinic acid (3β)-3-[4-(2-phenylmethoxycarbonyl)-3,3-dimethyl-1-oxobutoxy]lup-20(29)-en-28-al (R)-4-[3β-hydroxy-28-norlup-20(29)-en-17β-yl]-γ-butyrolactone betulin

    合成工艺路线路线简述

      📜白桦脂酸置于4-二甲氨基吡啶,Lithium Aluminium Tetrahydride,草酰氯,N,N-二异丙基乙胺,N,N-二甲基甲酰胺体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 152.0H,反应生成白桦脂醛
      参考文献: Triterpene Amine Derivatives[fr] Dérivés D'Amine Triterpénique
      标题: Triterpene Amine Derivatives[fr] Dérivés D'Amine Triterpénique
      摘要:本发明涉及新型具有药用活性的三萜胺衍生物,含有这些衍生物的药物组合物,它们作为药物的用途,以及用这些化合物制造特定药物的用途.本发明还涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉及涉

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      专利信息


      专利号:US-2009131714-A1
      优先权日:2005-06-08
      标题:Synthesis of betulonic and betulinic aldehydes
      发明人：KRASUTSKY PAVEL A; MUNSHI KALYAN
      权利人:KRASUTSKY PAVEL A; MUNSHI KALYAN
      摘要:The present invention provides for methods of selectively converting betulin to betulonic aldehyde. The present invention also provides for methods of selectively converting 3-substituted triterpen-28-ols to the corresponding 3-substituted triterpen-28-carboxaldehydes. Additionally, the present invention provides for methods of preparing betulonic aldehyde, betulonic acid, betulinic acid, and corresponding 3-substituted triterpenes.

      专利号:WO-2006133314-A2
      优先权日:2005-06-08
      标 题:Synthesis of betulonic and betulinic aldehydes

      专利号:CN-115626947-A
      优先权日:2022-09-27
      标 题 :Synthesis and application of pentacyclic triterpenes natural products

      专利号:CN-115626947-B
      优先权日:2022-09-27
      标 题:Synthesis and application of pentacyclic triterpenoid natural products

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      主要参考文献

      1. Suksamrarn, S., Panseeta, P., Kunchanawatta, S., et al. Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana. Chem. Pharm. Bull. (Tokyo) 54(4), 535-537 (2006). 2. Chung, P.Y., Chung, L.Y., and Navaratnam, P. Potential targets by pentacyclic triterpenoids from Callicarpa farinosa against methicillin-resistant and sensitive Staphylococcus aureus. Fitoterapia 94, 48-54 (2014). 3. Peyrat, L.-A., Eparvier, V., Eydoux, C., et al. Chemical diversity and antiviral potential in the pantropical Diospyros genus. Fitoterapia 112, 9-15 (2016). 4. Hata, K., Hori, K., Ogasawara, H., et al. Anti-leukemia activities of Lup-28-al-20(29)-en-3-one, a lupane triterpene. Toxicol. Lett. 143(1), 1-7 (2003).

      合成参考文献


      参考文献:10.1248/cpb.26.3050
      摘要:NAKAJIMA K, TAGUCHI H, ENDO T, YOSIOKA I. The constituents of Scirpus fluviatilis(Torr). A. Gray. I. The structures of two new hydroxystilbene dimers, scirpusin A and B. Chem. Pharm. Bull. 1978;26(10):3050–7. doi: 10.1248/cpb.26.3050.
      参考文献:10.1021/np9606052
      摘要:Lee C. A New Norlupene from the Leaves ofMelaleucaleucadendron. J. Nat. Prod. 1998 Mar 01;61(3):375–6. doi: 10.1021/np9606052.
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