专利号:US-7189849-B2 优先权日:1997-02-10 标 题:Synthesis of acyclic nucleoside derivatives 发明人:LEANNA M ROBERT; RASMUSSEN MICHAEL; HANNICK STEVEN M; TIEN JIEN-HEH J; LUKIN KIRILL A; TIAN ZHENPING; CHANG SOU-JEN; CURTY CYNTHIA B; NARAYANAN BIKSHANDARKOIL A; BELLETTINI JOHN; SHELAT BHADRA; SPITZ TIFFANY 权利人:MEDIVIR AB 摘要:Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.
专利号:US-3959322-A 优先权日:1960-09-22 标 题:Synthesis of 13-alkyl-gon-4-ones 发明人:HUGHES GORDON ALAN; SMITH HERCHEL 权利人:SMITH HERCHEL 摘要:The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.
专利号:WO-0212185-A1 优先权日:2000-08-10 标 题:Process for preparing 2,3-diaminopropanols and synthesis of other compounds using 2,3-diaminopropanols 发明人:LEE WON KOO; SHIN SEONG-HO; HA HYUN-JOON 权利人:CHEMBIONEX CO LTD; HANSOL CHEMIENCE CO LTD; LEE WON KOO; SHIN SEONG HO; HA HYUN JOON 摘要:The invention relates to a process for producing 2,3-diaminopropanol of formula (II) from aziridine of formula (I) wherein, R1 is selected from a group consisting of hydrogen, alkyl, cycloalkyl, acyl, aryl, hydrocarbon residues, aralkyl, and those groups substituted with suitable substituent(s); R2 is selected from a group consisting of hydrogen, alkyl, cycloalkyl, C¿2 -C5-alkenyl, aralkyl which may be optionally substituted with suitable substituent(s), aryl which may be optionally substituted with suitable substituent(s), and heteroaryl which may be optionally substituted with suitable substituent(s); each of R 3 and R4¿ is independently selected from a group consisting of hydrogen, C¿1 -C12 alkyl, C1-C12 alkylcarbonyl, C1-C12 alkyloxycarbonyl, aryl, mono- or di(C1-C12)alkylamino, mono- or di(C1-C12)amino carbonyl, wherein C1-C12 may be optionally substituted, or R 3 and R4¿, together with nitrogen atom which they are attached to, may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C¿1 -C12)alkylamino C1-C4 alkylidene.
专利号:US-2012277444-A1 优先权日:2011-04-27 标 题:Synthesis of hydroxyalkyl amides from esters 发明人:MAHADEVAN SHIVKUMAR; VENKATASUBBAN KUNISI 权利人:MAHADEVAN SHIVKUMAR; VENKATASUBBAN KUNISI 摘要:Hydroxyamides are synthesized from esters. A process of making hydroxyalkyl amides comprises: reacting an ester with a hydroxyalkyl amine having the formula H 2 N—R 3 —OH wherein R 3 is a substituted or unsubstituted C2 to C5 alkyl, in the presence of a catalyst in an anhydrous solution to form the hydroxyalkyl amides. Monomers suitable for formation of polymeric articles can utilize these hydroxyamides.
专利号:US-5098602-A 优先权日:1988-05-11 标题 :Novel halogen-containing ester compounds, and their intermediates, and method of producing the same as well as liquid crystal compositions containing the same and light switching elements 发明人:HIRAI TOSHIHIRO; YOSHIZAWA ATSUSHI; NISHIYAMA ISA; FUKUMASA MITSUO; SHIRATORI NOBUYUKI; YOKOYAMA AKIHISA 权利人:NIPPON MINING CO 摘要:This invention provides a novel halogen-containing ester compound represented by the following general formula (I): ##STR1## (wherein R is an alkyl group, A is selected from a single bond, --O--, --COO-- and --CO--, both of X and Y are halogen atoms or either one of X and Y is a halogen atom and the other is a hydrogen atom, each of m and n is 0 or 1, m+n=0 or 1, each of k and l is an integer of 1 or more, provide k 专利号:US-8575081-B2 优先权日:2008-01-31 标 题:Synthesis of diester-based biolubricants from epoxides 发明人:MILLER STEPHEN JOSEPH; ZHOU ZHEN; ELOMARI SALEH A 权利人:MILLER STEPHEN JOSEPH; ZHOU ZHEN; ELOMARI SALEH A; CHEVRON USA INC 摘要:The present invention is generally directed to methods of making diester-based lubricant compositions, wherein formation of diester species proceeds via direct esterification of epoxide intermediates. In some embodiments, the methods for making such diester-based lubricants utilize a biomass precursor and/or low value (e.g., Fischer-Tropsch (FT) olefins and/or alcohols) so as to produce high value diester-based lubricants. In some embodiments, such diester-based lubricants are derived from FT olefins and fatty acids. The fatty acids can be from a bio-based source (i.e., biomass, renewable source) or can be derived from FT alcohols via oxidation.
摘要:Toyota, S.; Iwanaga, T., Science of Synthesis, (2010) 45, 816. 摘要:Khartulyari, A.; Maier, M. E., Science of Synthesis Knowledge Updates, (2010) 3, 70. 摘要:Witt, D., Science of Synthesis Knowledge Updates, (2011) 3, 297. 摘要:Pitaval, A.; Echavarren, A. M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 564.