CAS: 109-96-6; 2,5-Dihydro-1H-Pyrrole

上下游产品

CAS号73286-70-1 N-B°C-3-吡咯啉 | CAS号109-97-7 吡咯 | CAS号7153-66-4 顺-4-氯-2-丁烯胺 盐酸盐 | CAS号63603-33-8 methyl 2,5-dihy... | CAS号6972-81-2 Ethyl 2,5-dihyd... | CAS号1476-11-5 顺式1,4-二氯-2-丁烯 | CAS号63468-63-3 2,5-二氢吡咯盐酸盐 | CAS号124-02-7 二烯丙基胺 | CAS号111185-41-2 1H-Pyrrole, 2,5... | CAS号107484-31-1 1-[(4-nitrophen... | CAS号31970-04-4 3-吡咯烷-1-甲酸苄酯 | CAS号123-75-1 四氢吡咯 | CAS号109-97-7 吡咯 | CAS号246540-50-1 N-甲磺酰基-3-吡咯啉 | CAS号6913-92-4 N-苄基-2,5-二氢吡咯 | CAS号2905-56-8 1-苄基哌啶 | CAS号73286-70-1 N-B°C-3-吡咯啉 | CAS号86953-79-9 1-B°C-四氢吡咯

吡咯置于盐酸,对苯二甲酸,锌体系中,用 水,二甲基亚砜 用作溶剂,化学反应 6.0H,以10.12%的收率获得3-吡咯啉
参考文献:一种基于改进活化锌粉制备3-吡咯啉的方法
标题:一种基于改进活化锌粉制备3-吡咯啉的方法
摘要:本发明公开了一种基于改进活化锌粉制备3‑吡咯啉的方法,属于医药技术领域,以二甲基亚砜作用作溶剂,使用芳香族羧酸活化锌粉,过滤后得到活性锌粉.活性锌粉与盐酸反应生成活泼氢,用于吡咯选择性加氢生成3‑吡咯啉.本发明使用的芳香族羧酸不仅能去除锌粉表面的氧化锌,也能与锌形成空间网状结构的配位化合物,增强了活化后锌粉的安全性,有效提高了锌粉的反应活性和吡咯选择性加氢反应的选择性.同时,通过二甲基亚砜对锌粉的分散作用,增强了锌粉的活化效果;在吡咯选择性加氢过程中活性锌表面络合的二甲基亚砜能有效捕捉氢离子并传输给锌粉,促进活泼氢的产生,提高了反应的转化率.

专利信息

专利号:WO-2013138200-A1
优先权日:2012-03-13
标 题 :Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof
发明人：FORTUNAK JOSEPH MARIAN; KULKARNI AMOL ANANT; KING CHRISTOPHER
权利人:UNIV HOWARD
摘要:Methods are provided for a green chemistry one-pot synthesis of amodiaquine and amodiaquine analogs. The methods have a lower environmental impact, lower investment cost, reduced amounts of byproducts and impurities, and a shorter synthesis time, compared to current conventional synthesis methods. The methods reduce the total number of steps in the synthesis from four to five down to two, thereby simplifying production; and allow a reduced number of solvents and reagents to be used in production, thereby reducing the waste generated in the synthesis. The methods can reduce the waste to about 3-5 kilograms of waste generated per kilogram of product produced; and surprisingly improve the overall yield from 60-65% to greater than 90% as compared to the current conventional synthesis methods for amodiaquine and its analogs.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-9376461-B2
优先权日:2011-06-06
标 题:Non-enzymatic synthesis of O-acetyl-ADP-ribose and analogues thereof
发明人：KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B
权利人:KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B; GLAXOSMITHKLINE LLC
摘要:Provided herein is a simple, one-step, non-enzymatic synthesis of O-Acetyl-ADP-ribose (OAADPR) from NAD and sodium acetate in acetic acid. The extension of this reaction to other carboxylic acids, demonstrates that the reaction between NAD, and NAD analogs produces mixtures of the corresponding 2′- and 3′-carboxylic esters. Included are O-carboxyl-ADP-ribose compounds and corresponding methods of synthesis (e.g., O-propionyl-ADP-ribose, O-succinyl-ADP-ribose, O-malonyl-ADP-ribose), as well as non-adenosine nucleoside compounds.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:US-8877930-B2
优先权日:2009-11-04
标 题 :Continuous flow synthesis of amino alcohols using microreactors
发明人：BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F
权利人:BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F; MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.