CAS: 1025065-69-3; N-((1-Methylpiperidin-4-yl)Methyl)-3-(3-(Trifluoromethoxy)Phenyl)Imidazo[1,2-B]Pyridazin-6-Amine

上下游产品

1-(1-methylpiperidin-4-yl)methanamine 6-chloro-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine

📜(1-甲基-4-哌啶-)甲胺,6-Chloro-3-(3-(Trifluoromethoxy)Phenyl)Imidazo[1,2-B]Pyridazine置于苄基三乙基氯化铵,Cesium Fluoride体系中,用 二甲基亚砜 用作溶剂,以91 %的收率获得化合物sgi-1776Freebase
参考文献:C-6 胺化 3-溴咪唑并[1,2-B]哒嗪的高效合成
标题:C-6 胺化 3-溴咪唑并[1,2-B]哒嗪的高效合成
摘要:在 Dmso 中于 100 ° 下用各种 1° 或 2° 烷基胺(2.0 当量),Csf(1.0 当量)和 Bnnet3Cl(10 Mol%)处理 3-溴-6-氯咪唑并[1,2-B]哒嗪c(24小时)给出了对应的...
Doi:10.1080/00397911.2023.2284350

专利信息

专利号:US-11319320-B2
优先权日:2017-11-06
标题:PIM kinase inhibitor compositions, methods, and uses thereof
发明人：BURK MARK J; CHEN BRANDON; LI JINGYI; BACHAN SHAWN
权利人:SNAP BIO INC
摘要:This application relates to compounds of formulae (I) and (II) and compositions thereof useful as inhibitors of PIM kinases. Also provided are methods of synthesis and methods of use of PIM inhibitors in treating individuals suffering from cancerous malignancies.

专利号:WO-2022162606-A1
优先权日:2021-01-30
标 题:Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：YAN ZHIYU; WANG XIAOHUI; LIU HANLAN; KHAN PASHA M; PANPATIL DAYANAND; PUJALA BRAHMAM; PENDHARKAR DHANANJAY; JADHAVAR PRADEEP S; SAEED UZMA; KUMAR VIVEK
权利人:SPEROGENIX THERAPEUTICS LTD; INTEGRAL BIOSCIENCES PRIVATE LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (J), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes such as cancer, idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed. Formula (J)