CAS: 964-52-3; 4-(2-(Dimethylamino)Ethoxy)-5-Isopropyl-2-Methylphenyl Acetate Hydrochloride
该化合物是选择性的α1-Adnergy 受体敌物,主要用于涉及血管变异的药物研究和临床应用,其主要优势在于能够以高特异性阻塞α1受体,使其成为研究血管滑动肌肉收缩和周边血液流动调节的宝贵工具.复合物显示出可靠的生物可用性和可预测的药用动因,有利于可复制的实验结果.在标准实验室条件下,盐酸甲醚也因其稳定性而得到注意,确保体外和体外研究的一致性能.其有明确特征的行动机制有助于其在心血管和...
- 英文名称4-(2-(Dimethylamino)Ethoxy)-5-Isopropyl-2-Methylphenyl Acetate Hydrochloride
- 中文名称4-(2-二甲氨基乙氧基)-5-异丙基-2-甲基酯盐酸盐
- IUPAC名称4-(2-(dimethylamino)ethoxy)-5-isopropyl-2-methylphenyl acetate hydrochloride
- 其它别名Carvacrol, Acetate (Ester), Hydrochloride; Wk2Kzm9V6X; Pipotiazin Retard; 1-N-(L(-)-Gamma-Amino-Alpha-Hydroxybutyryl)
- CAS编号964-52-3
- MFCD编号:MFCD00079445
- EINECS号:213-519-4
- FDA UNII编号:WK2KZM9V6X
- 分子式:C16H26ClNO3分子量:315.84
- 产品CID: 2017518
- 同类组份化合物CAS54-32-0 (free base)964-52-3 (HCl)
- 产品分类有机原料 → 脂质和类脂质分子 → 异戊烯醇脂质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
- 35231-36-8 = 964-52-3 [标题:Reaction Conditions
标题:Moxisylyte Hydrochloride
参考文献:Japan]
= 964-52-3 [标题:Reaction Conditions
标题:Synthesis And Pharmacological Evaluation Of New Indole Derivatives Structurally Related To Thymoxamine
作者:Leonardi,A.; Riva,C.; De Toma,C.; Boi,C.; Pennini,R.; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:1994 卷标:29(7-8) 页码:551-9]
= 964-52-3 [标题:Reaction Conditions
标题:Preparation Of Phenyl Carboxylates
参考文献:Japan]
= 964-52-3 [标题:Reaction Conditions
标题:Deacetylmoxisylyte
参考文献:Japan]
= 964-52-3 [标题:Reaction Conditions
标题:5-[2-(Dimethylamino)Ethoxy]Carvacrol Acetate Hydrochloride
参考文献:Japan]
= 964-52-3 [标题:Reaction Conditions
标题:5-[2-Dimethylaminoethoxy]Carvachlor Acetate Hydrochloride
参考文献:Japan]
= 964-52-3 [标题:Reaction Conditions
标题:5-[2-(Dimethylamino)Ethoxy]Carvacryl Acetate Hydrochloride
参考文献:Japan]
54-32-0 = 964-52-3
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Diethyl Ether
标题:Synthesis Of Thymoxamine Hydrochloride
作者:Han,Hua-Niang; Pang,Li-Hong
参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2000 卷标:31(9) 页码:386-389]
35231-36-8 = 964-52-3
反应条件:1.1 Reagents: Hydrochloric Acid
标题:Process For The Preparation Of Moxisylyte Hydrochloride
参考文献:Japan]
35231-36-8 = 964-52-3 [标题:Reaction Conditions
标题:Preparation Of A Thymol Derivative As An Intermediate For Moxisylyte Hydrochloride
参考文献:Japan]
= 964-52-3 [标题:Reaction Conditions
标题:Preparation Of 4-Acetyloxy-1-(2-Substituted-Ethoxy)Benzenes As Drugs
参考文献:Japan]
= 964-52-3 [标题:Reaction Conditions
标题:Preparation Of [2-(4-Acetoxy-2-Isopropyl-5-Methylphenoxy)Ethyl]Dimethylamine Hydrochloride As A Sympatholytic Agent
参考文献:Japan]
= 964-52-3 [标题:Reaction Conditions
标题:5-[2-(Dialkylamino)Ethoxy]Carvacrol Acetate Hydrochloride Salts
参考文献:Japan]
= 964-52-3 [标题:Reaction Conditions
标题:5-[2-(Dimethylamino)Ethoxy]Carvacryl Acetate
参考文献:Japan]
= 964-52-3 [标题:Reaction Conditions
标题:4-(2-(Dimethylamino)Ethoxy)-2-Methyl-5-(1-Methylethyl)Phenol Esters And Their Salts
参考文献:European Patent Organization
📜2-(4-羟基-5-甲基-2-丙-2-基苯氧基)乙基-二甲基氯化铵 反应生成 4-(2-二甲氨基乙氧基)-5-异丙基-2-甲基酯盐酸盐
参考文献:Kodzima,Kodzi;Sato,Madasi
标题:Kodzima,Kodzi;Sato,Madasi
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8354116-B2
优先权日:2007-06-18
标题 :Bifunctional synthetic molecules
发明人：CARTER STEPHEN G; PATEL KANU; ZHU ZHEN; QIAO LIXIN
权利人:BIOCHEMICS INC; CARTER STEPHEN G; PATEL KANU; ZHU ZHEN; QIAO LIXIN
摘要:The synthesis and use of bifunctional molecules to improve the topical and transdermal delivery efficiency of various types of therapeutic agents or agents designed to promote the transdermal delivery of those therapeutic agents either into the skin tissue or into the systemic circulation. Three major classes of molecules are covalently joined as bifunctional substances; chemical vasodilators, passive dermal penetration enhancers and therapeutic or diagnostic drugs. Chemical vasodilators may be delivered into the skin to increasing the blood flow in a tissue that has compromised circulation or they may be used as part of a delivery vehicle to promote the delivery of the drug. Passive dermal penetration enhancers are those chemicals that promote the passive penetration of drugs and other chemicals through the stratum corneum and epidermis of the skin tissue. Drugs and diagnostic agents are the third group of chemicals that are candidates for the linkage of molecules.
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主要参考文献
1: Sakakibara R, Hattori T, Uchiyama T, Suenaga T, Takahashi H, Yamanishi T, Egoshi K, Sekita N. Are alpha-blockers involved in lower urinary tract dysfunction in multiple system atrophy? A comparison of prazosin and moxisylyte. J Auton Nerv Syst. 2000 Mar 15;79(2-3):191-5. doi: 10.1016/s0165-1838(99)00105-8. 12(4):377-87. doi: 10.1111/j.1472-8206.1998.tb00961.x. 48(1):34-8. 159(1):116-9. doi: 10.1016/s0022-5347(01)64030-8. 691(2):389-96. doi: 10.1016/s0378-4347(96)00468-9. 8(2):41-6. 18(2):135-44. doi: 10.1097/00007691-199604000-00005. 102(4):151-6. French. 49(5):411-5. doi: 10.1007/BF00203788. 5(6):985-91. French. 45(11):1161-5. 5(5):690-6. French. 5(1):49-57. French. 45(1):10-4. 82(9):968-71. doi: 10.1002/jps.2600820920. 82(7):729-33. doi: 10.1002/jps.2600820711. 53(4):443-9. doi: 10.1038/clpt.1993.49. 149(2):301-5. doi: 10.1016/s0022-5347(17)36062-7. 21(2):173-6. French. 81(12):1223-6. doi: 10.1002/jps.2600811220.
合成参考文献
摘要:Therapie., 26(775), 1971 []
摘要:Kiso to Rinsho. Clinical Report., 16(147), 1982
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